10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 15 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
ICA (N-(pyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine) is a SK channel inhibitor that has antileishmanial activity with an IC 50 of 2.1 µM.
In Vitro
The SK channel inhibitor ICA exhibits antiarrhythmic effects. ICA prevents electrically induced runs of atrial fibrillation in the isolated right atrium and induces atrial postrepolarization refractoriness and depolarizes resting membrane potential. ICA at 1 to 10 μM slows conduction velocity. At increased pacing frequencies, SK channel inhibition by ICA (10-30 μM) demonstrates prominent depression of other sodium channel-dependent parameters. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
IC50& Target:IC50: 2.1 µM (Antileishmanial)
| Isomeric SMILES | C1=CC=NC(=C1)C2=CSC(=N2)NC3=CC=CC=N3 |
|---|---|
| PubChem CID | 772885 |
| NSC Number | 751858 |
| MeSH Entry Terms | N-(pyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine |
| Molecular Weight | 254.31 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| 1. Wenfu Lin, Yan Huang, Zhenru Li, Jiongshen Pan, Tiansheng Huang, Lili Liang, Yanzhen Tan, Jie Li, Li-Peng Sun, Bai-Ou Guan. (2023) ZIF-90-Derived Porous ZnO Coated Optical Microfiber Interferometer Sensor for Enhanced Humidity Sensing and Breath Monitoring. ACS Applied Materials & Interfaces, [PMID:37352511] [10.1021/acsami.3c06635] |
| 2. Ting Zhang, Keli Dong, Lan Xiao, Guangcheng Li, Zhanwei Zhang. (2022) Effects of Co-Administration of Icariin and Panax notoginseng Saponins on Intestinal Microbiota and Hippocampal Protein Expression in a Mouse Model of Alzheimer’s Disease. Neuropsychiatric Disease and Treatment, [PMID:33061388] [10.2147/NDT.S253972] |
| 3. Zhou Mengyang, Guo Min, Shi Xincui, Ma Jie, Wang Shutao, Wu Shuo, Yan Weiqun, Wu Feng, Zhang Peibiao. (2022) Synergistically Promoting Bone Regeneration by Icariin-Incorporated Porous Microcarriers and Decellularized Extracellular Matrix Derived From Bone Marrow Mesenchymal Stem Cells. Frontiers in Bioengineering and Biotechnology, [PMID:35464719] [10.3389/fbioe.2022.824025] |
| 4. Kun Li, Yingnan Zhang, Junwei Xu, Jingxi Wang, Xuenan Gu, Ping Li, Yubo Fan. (2021) Three-dimensional magnetic fibrous scaffold with icariin expanded by supercritical CO2 for bone tissue engineering under static magnetic field. COMPOSITES PART B-ENGINEERING, [PMID:] [10.1016/j.compositesb.2021.109304] |
| 5. He Qi, Zheng Li, Haijiao Zheng, Qiong Jia. (2021) Carnosine functionalized magnetic metal–organic framework nanocomposites for synergistic enrichment of phosphopeptides. ANALYTICA CHIMICA ACTA, [PMID:33832591] [10.1016/j.aca.2021.338383] |
| 6. Chenxi Yu, Wenyu Zhu, Zhaozhan He, Jin Xu, Fengyan Fang, Ziang Gao, Wenli Ding, Yixiang Wang, Jing Wang, Junqiao Wang, Ao Huang, Aohua Cheng, Yanhui Wei, Shiyun Ai. (2021) ATP-triggered drug release system based on ZIF-90 loaded porous poly(lactic-co-glycolic acid) microspheres. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, [PMID:] [10.1016/j.colsurfa.2021.126255] |
| 7. Xiaobang Liu, Ting Yue, Kai Qi, Bao Yu Xia, Zhenyu Chen, Yubing Qiu, Xingpeng Guo. (2020) Probe into metal-organic framework membranes fabricated via versatile polydopamine-assisted approach onto metal surfaces as anticorrosion coatings. CORROSION SCIENCE, [PMID:] [10.1016/j.corsci.2020.108949] |
| 8. Xiaofeng Shen, Pengfei Yu, Hua Chen, Jiangping Wang, Binjie Lu, Xuefeng Cai, Chun Gu, Guoqiang Liang, Donglin Hao, Qihan Ma, Yuwei Li. (2020) Icariin controlled release on a silk fibroin/mesoporous bioactive glass nanoparticles scaffold for promoting stem cell osteogenic differentiation. RSC Advances, 10 (20): (12105-12112). [PMID:35496600] [10.1039/D0RA00637H] |
| 9. Dan Zhang, Yu Fan, Gaojie Li, Wei Du, Runlong Li, Yiming Liu, Zhixuan Cheng, Jiaqiang Xu. (2019) Biomimetic synthesis of zeolitic imidazolate frameworks and their application in high performance acetone gas sensors. SENSORS AND ACTUATORS B-CHEMICAL, [PMID:] [10.1016/j.snb.2019.127187] |
| 10. Xiaoxu Zhao, Hao Zhang, Sheng Xu, Yan Wang. (2019) ZIF-8 membrane synthesized via covalent-assisted seeding on polyimide substrate for pervaporation dehydration. AICHE JOURNAL, 65 (8): (e16620). [PMID:] [10.1002/aic.16620] |
| 11. Haotian Li, Xinran Zhang, Xi Qi, Xu Zhu, Liming Cheng. (2019) Icariin Inhibits Endoplasmic Reticulum Stress-induced Neuronal Apoptosis after Spinal Cord Injury through Modulating the PI3K/AKT Signaling Pathway. International Journal of Biological Sciences, [PMID:30745820] [10.7150/ijbs.30348] |
| 12. Yan Dan, He Yu, Ge Yili, Song Gongwu. (2016) Fluorescent Detection of Phosphate in Aqueous Solution Based on Near Infrared Emission Ag2S QDs/Metal − Organic Shell Composite. JOURNAL OF FLUORESCENCE, 27 (1): (227-233). [PMID:27726052] [10.1007/s10895-016-1949-2] |
| 13. Xuan Chen, Qiang Ren, Jingmei Xu, Mengchi Ju, Lingxin Meng, Zhe Wang. (2023) Design, transport efficiency and structure-activity relationship of sulfonated poly (aryl ether ketone) proton exchange membrane based on multi-functional MOFs. ELECTROCHIMICA ACTA, [PMID:] [10.1016/j.electacta.2023.143210] |
| 14. Zhu Tengyang, Zhao Xiaoxu, Yi Ming, Xu Sheng, Wang Yan. (2021) Ternary cross-linked PVA-APTES-ZIF-90 membrane for enhanced ethanol dehydration performance. Advanced Composites and Hybrid Materials, 5 (1): (91-103). [PMID:] [10.1007/s42114-021-00218-z] |
| 15. Qiufang Chen, Bin Deng, Qing Luo, Guanbin Song. (2020) Deep tumor‐penetrated nanosystem eliminates cancer stem cell for highly efficient liver cancer therapy. CHEMICAL ENGINEERING JOURNAL, [PMID:] [10.1016/j.cej.2020.127874] |
