≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
ICI-118551 is a highly selectiveβ2-adrenergic receptor antagonistwithKivalues of 0.7, 49.5 and 611 nM for β2, β1 and β3 receptors, respectively.
Targets
β2-adrenergic receptor (Cell-free assay); β1-adrenergic receptor (Cell-free assay); β3-adrenoceptor (Cell-free assay) 0.7nM(Ki); 49.5nM(Ki); 611nM(Ki)
In vitro
ICI-118551 inhibits cAMP accumulation by 50% (IC50 = 1.7 mM). Pharmacological experiments proves that the right shift of the norepinephrine dose-response curve by ICI 118551 is mediated via a beta(2)-adrenoceptor/G(i/o) protein-dependent pathway enhancing NO production in the endothelium; these results are corroborated in beta-adrenoceptor and endothelial NO synthase knockout mice where ICI 118551 has no effect. ICI 118551 increases vascular lumen diameter in lung sections and reduces pulmonary arterial pressure under normoxia and under hypoxia in the isolated perfused lung model. Transgenic mice with high beta(2)AR number and increased G(i) levels have normal basal contractility but show a similar negative inotropic response to ICI 118,551. Overexpression of human beta(2)AR in rabbit myocytes using adenovirus potentiates the negative inotropic effect of ICI 118,551. In human, rabbit, and mouse myocytes, the negative inotropic effects are blocked after treatment of cells with pertussis toxin to inactivate G(i), and overexpression of G(i)alpha(2) induces the effect de novo in normal rat myocytes.
In vivo
After 1 week of treatment, ICI 118,551 has no effect on the beta 1-receptor mediated shortening of electromechanical systole (QS2I), the rise in systolic pressure and rise in renin, whereas these responses are blocked by a dose factor of eight after propranolol. ICI 118,551 and propranolol equally block the beta 2-receptor mediated fall in diastolic pressure and the rise in noradrenaline. beta 2-selective blockade by ICI 118,551 lowers blood pressure.
Cell Research(from reference)
Cell lines：MEF cell line
Concentrations：10μM
Incubation Time：2-hours incubation at room-temperature
| Canonical Smiles | CC1=C2CCCC2=C(C=C1)OCC(C(C)NC(C)C)O.Cl |
|---|---|
| IUPAC Name | 1-[(7-methyl-2,3-dihydro-1H-inden-4-yl)oxy]-3-(propan-2-ylamino)butan-2-ol;hydrochloride |
| InChIKey | KBXMBGWSOLBOQM-UHFFFAOYSA-N |
| INCHI | 1S/C17H27NO2.ClH/c1-11(2)18-13(4)16(19)10-20-17-9-8-12(3)14-6-5-7-15(14)17;/h8-9,11,13,16,18-19H,5-7,10H2,1-4H3;1H |
| Isomeric SMILES | CC1=C2CCCC2=C(C=C1)OCC(C(C)NC(C)C)O.Cl |
| Molecular Weight | 313.86 |
| Reaxy-Rn | 6881490 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=6881490&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
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View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Benzenoids |
| Class | Indanes |
| Subclass | Not available |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Indanes |
| Alternative Parents | Alkyl aryl ethers Secondary alcohols 1,2-aminoalcohols Dialkylamines Organopnictogen compounds Hydrochlorides Hydrocarbon derivatives |
| Molecular Framework | Aromatic homopolycyclic compounds |
| Substituents | Indane - Alkyl aryl ether - 1,2-aminoalcohol - Secondary alcohol - Secondary aliphatic amine - Ether - Secondary amine - Organic nitrogen compound - Organooxygen compound - Organonitrogen compound - Hydrochloride - Hydrocarbon derivative - Organopnictogen compound - Amine - Organic oxygen compound - Alcohol - Aromatic homopolycyclic compound |
| Description | This compound belongs to the class of organic compounds known as indanes. These are compounds containing an indane moiety, which consists of a cyclopentane fused to a benzene ring. |
| External Descriptors | Not available |
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Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 K2521100 | Certificate of Analysis | Dec 03, 2025 | I413910 |
| I2305424 | Certificate of Analysis | Jun 10, 2025 | I413910 |
| I2305425 | Certificate of Analysis | Jun 10, 2025 | I413910 |
| I2305426 | Certificate of Analysis | Jun 10, 2025 | I413910 |
| I2305427 | Certificate of Analysis | Jun 10, 2025 | I413910 |
| I2305428 | Certificate of Analysis | Jun 10, 2025 | I413910 |
| Solubility | Solubility (25°C) In vitro DMSO: 62 mg/mL (197.54 mM); Ethanol: 62 mg/mL (197.54 mM); Water: 21 mg/mL (66.9 mM); |
|---|---|
| Molecular Weight | 313.900 g/mol |
| XLogP3 | |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 6 |
| Exact Mass | 313.181 Da |
| Monoisotopic Mass | 313.181 Da |
| Topological Polar Surface Area | 41.500 Ų |
| Heavy Atom Count | 21 |
| Formal Charge | 0 |
| Complexity | 295.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 2 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 2 |
