BioReagent BioReagent for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at 2-8°C Ships Wet ice Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
IMDM (Iscove’s Modified Dulbecco Medium) was developed by Guilber and Iscove in 1976 for the culture of erythroid precursor cells and macrophages. Based on DMEM, IMDM is supplemented with selenium, HEPES, sodium pyruvate, and additional amino acids and vitamins, and replaces ferric nitrate with potassium nitrate. It is nutritionally rich and highly suitable for rapidly proliferating, high‑density cell cultures. IMDM can be used not only for cells with special nutritional requirements (such as mouse B lymphocytes, LPS‑stimulated B cells, bone marrow hematopoietic cells, T lymphocytes, and various hybridoma cells), but also serves as a basal medium for some unique serum‑free formulations. Phenol red is used in the medium as a pH indicator to continuously monitor the acidity/alkalinity of the culture fluid. At low pH, phenol red turns the medium yellow; at high pH, it turns purple; at pH 7.2–7.4, it appears red, which is optimal for cell culture. However, phenol red has some drawbacks. Studies have shown that phenol red can mimic the action of steroid hormones, particularly estrogens. Therefore, when using estrogen‑sensitive cells (e.g., breast tissue), it is advisable to use phenol‑red‑free medium. Phenol red can also interfere with flow cytometry analysis. In addition, the presence of phenol red in some serum‑free formulations may disturb the sodium‑potassium balance. This product contains multiple components required for cell culture, including amino acids, vitamins, inorganic salts, etc.; however, it contains no proteins, lipids, or any growth factors. Therefore, this product must be used with serum or serum‑free supplements. Precautions 1. This product has been sterilized by filtration. Aseptic techniques must be observed during handling to prevent contamination. 2. To maintain optimal performance, avoid freeze‑thaw cycles. 3. This product is intended for research or further study purposes only; it is not for diagnostic or therapeutic use.
Comprehensive hazard, handling, storage, and regulatory compliance document.
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