Kanamycin solution - BioReagent,for cell culture,Derived from Streptomyces kanamycinius, filtered through a 0.1 μm membrane, 10 mg/mL in 0.9% NaCl , Bacterial 70S ribosome inhibitor, CAS No.25389-94-0, Bacterial 70S ribosome inhibitor

CAS: 25389-94-0 Cat. No.: K432458 Molecular Weight: 582.58 Beilstein Registry Number: 18(4)7631 EC Number: 246-933-9

GRADE & PURITY BioReagent, for Cell culture, Derived from Streptomyces kanamycinius, filtered through a 0.1 μm membrane, 10 mg/mL in 0.9% NaCl

Synonyms

Cantrex | KANAMYCIN MONO SULFATE | Kannasyn | J80EX28SMQ | KANAMYCIN SULFATE [GREEN BOOK] | KANAMYCIN A SULFATE [MI] | Kanamytrex | Kanatrol | s2315 | (2R,3S,4S,5R,6R)-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-3-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydro

Storage

Store at 2-8°C

Shipped In

Wet ice

Overview

General Description

Chemical structure: aminoglycoside

Application

Kanamycin sulfate is a broad spectrum aminoglycoside-antibiotic derived from Streptomyces kanamyceticus . It is used as an additive in culture media for the isolation of group D streptococci on Kanamycin Esculin Azide Agar and for selection of transformed plant cells containing the neomycin phosphotransferase on a kanamycin-medium. Kanamycin sulfate can also be used as a selection agent for cells transformed with kanamycin B resistance gene. It is recommended for use in cell culture applications at 10 ml/L.

Specifications

Synonyms

Cantrex | KANAMYCIN MONO SULFATE | Kannasyn | J80EX28SMQ | KANAMYCIN SULFATE [GREEN BOOK] | KANAMYCIN A SULFATE [MI] | Kanamytrex | Kanatrol | s2315 | (2R, 3S, 4S, 5R, 6R)-2-(aminomethyl)-6-[(1R, 2R, 3S, 4R, 6S)-4, 6-diamino-3-[(2S, 3R, 4S, 5S, 6R)-4-amino-3, 5-dihydro

Specifications & Purity

BioReagent, for cell culture, Derived from Streptomyces kanamycinius, filtered through a 0.1 μm membrane, 10 mg/mL in 0.9% NaCl

Biochemical and Physiological Mechanisms

Mode of Action: The product acts by binding to the 70S ribosomal subunit, inhibiting translocation and eliciting miscoding. Mode of Resistance: Aminoglycoside-modifying enzymes (including acetyltransferase, phosphotransferase, nucleotidyltransferase) can

Storage

Store at 2-8°C

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

BioReagent, for Cell culture

Action Type

INHIBITOR

Mechanism of action

Bacterial 70S ribosome inhibitor

Note

Note: Solutions are stable at 37°C for approximately 5 days. Aqueous stock solutions can be stored at 2-8°C for long-term storage.

Names and Identifiers

• Canonical Smiles: C1C(C(C(C(C1N)OC2C(C(C(C(O2)CN)O)O)O)O)OC3C(C(C(C(O3)CO)O)N)O)N.OS(=O)(=O)O
• IUPAC Name: (2R,3S,4S,5R,6R)-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-3-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane-3,4,5-triol;sulfuric acid
• InChIKey: OOYGSFOGFJDDHP-KMCOLRRFSA-N
• INCHI: 1S/C18H36N4O11.H2O4S/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17;1-5(2,3)4/h4-18,23-29H,1-3,19-22H2;(H2,1,2,3,4)/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-;/m1./s1
• Isomeric SMILES: C1[C@H]([C@@H]([C@H]([C@@H]([C@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CN)O)O)O)O)O[C@@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)N)O)N.OS(=O)(=O)O
• RTECS: NZ3225030
• Alternate CAS: 70560-51-9
• UN Number: 2811
• Packing Group: III
• Molecular Weight: 582.58
• Beilstein: 18(4)7631
• Reaxy-Rn: 18153648
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=18153648&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic oxygen compounds
    • Class Organooxygen compounds
      • Subclass Carbohydrates and carbohydrate conjugates
        • Level5 Aminosaccharides
          • Level6 Aminoglycosides
            • Level7 Aminocyclitol glycosides
              • Level8 2-deoxystreptamine aminoglycosides
                • Level9 4,6-disubstituted 2-deoxystreptamines

• Kingdom: Organic compounds
• Superclass: Organic oxygen compounds
• Class: Organooxygen compounds
• Subclass: Carbohydrates and carbohydrate conjugates
• Intermediate Tree Nodes: Aminosaccharides - Aminoglycosides - Aminocyclitol glycosides - 2-deoxystreptamine aminoglycosides
• Direct Parent: 4,6-disubstituted 2-deoxystreptamines
• Alternative Parents: O-glycosyl compounds Aminocyclitols and derivatives Cyclohexanols Cyclohexylamines Organic sulfuric acids Monosaccharides Oxanes 1,2-aminoalcohols Polyols Acetals Oxacyclic compounds Organopnictogen compounds Organic oxides Monoalkylamines Hydrocarbon derivatives Primary alcohols
• Molecular Framework: Aliphatic heteromonocyclic compounds
• Substituents: 4,6-disubstituted 2-deoxystreptamine - Glycosyl compound - O-glycosyl compound - Aminocyclitol or derivatives - Cyclohexanol - Cyclohexylamine - Sulfuric acid - Cyclitol or derivatives - Monosaccharide - Oxane - Cyclic alcohol - Organic sulfuric acid or derivatives - 1,2-aminoalcohol - Secondary alcohol - Polyol - Acetal - Organoheterocyclic compound - Oxacycle - Organonitrogen compound - Primary aliphatic amine - Hydrocarbon derivative - Organic oxide - Primary amine - Organopnictogen compound - Organic nitrogen compound - Amine - Alcohol - Primary alcohol - Aliphatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as 4,6-disubstituted 2-deoxystreptamines. These are 2-deoxystreptamine aminoglycosides that a glycosidically linked to a pyranose of furanose unit at the C4- and C6-positions.
• External Descriptors: aminoglycoside sulfate salt

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

Discover Target: TDP1

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Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

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Streptococcus pneumoniae (31063 Activities)

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Pseudomonas aeruginosa (123386 Activities)

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Klebsiella pneumoniae (43867 Activities)

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Proteus vulgaris (5823 Activities)

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Micrococcus luteus (7463 Activities)

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Staphylococcus aureus (210822 Activities)

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Staphylococcus epidermidis (22802 Activities)

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Escherichia coli (133304 Activities)

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Proteus mirabilis (3894 Activities)

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Salmonella (646 Activities)

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Salmonella enteritidis (727 Activities)

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Serratia marcescens (3237 Activities)

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Streptococcus pyogenes (16140 Activities)

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Bacillus subtilis (32866 Activities)

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Mycobacterium tuberculosis (203094 Activities)

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Enterococcus faecalis (29875 Activities)

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Bacillus cereus (7522 Activities)

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Candida albicans (78123 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

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Mechanisms of Action

Chemical and Physical Properties

• Specific Rotation[α]: 117.5 ° (C=1, H2O)
• Melt Point(°C): 250°C(dec.)(lit.)
• Molecular Weight: 582.600 g/mol
• Hydrogen Bond Donor Count: 13
• Hydrogen Bond Acceptor Count: 19
• Rotatable Bond Count: 6
• Exact Mass: 582.205 Da
• Monoisotopic Mass: 582.205 Da
• Topological Polar Surface Area: 366.000 Ų
• Heavy Atom Count: 38
• Formal Charge: 0
• Complexity: 720.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 15
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3

References

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17. Wang Yang, Jin Daobin, Zhang Xiaoqian, Zhao Jikuan, Hun Xu.  (2022)  Self-enhancement photoelectrochemical strategy for kanamycin determination with amino functionalized MOFs.  MICROCHIMICA ACTA,  189  (5): (1-7).  [PMID:35426050] [10.1007/s00604-022-05266-w]

18. Xuelian Hu, Ying Guo, Jinni Zhang, Xiaohui Wang, Guozhen Fang, Shuo Wang.  (2022)  A signal-amplified ratiometric fluorescence biomimetic sensor based on the synergistic effect of IFE and AE for the visual smart monitoring of oxytetracycline.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2022.134499]

19. Zhou Li-Jian, Guo Li-Bin, Wei Wei, Lv Zhi-Xiang, Zhang Ye-Wang.  (2021)  A Novel Chondroitin AC Lyase With Broad Substrate Specificity From Pedobacter rhizosphaerae: Cloning, Expression, and Characterization.  Frontiers in Bioengineering and Biotechnology,      [PMID:35004658] [10.3389/fbioe.2021.808872]

20. Qi Nie, Jingjing Deng, Bing Xie, Guoyue Shi, Tianshu Zhou.  (2021)  A dual-channel colorimetric and fluorescent sensor for the rapid and ultrasensitive detection of kanamycin based on gold nanoparticles-copper nanoclusters.  Analytical Methods,  13  (48): (5813-5820).  [PMID:34852031] [10.1039/D1AY01460A]

21. Wanling Cui, Guodong Hu, Enguang Lv, Chonghui Li, Zhenxing Wang, Qiang Li, Zhaohong Qian, Jihua Wang, Shicai Xu, Rui Wang.  (2021)  A label-free and enzyme-free fluorescent aptasensor for amplified detection of kanamycin in milk sample based on target-triggered catalytic hairpin assembly.  FOOD CONTROL,      [PMID:] [10.1016/j.foodcont.2021.108654]

22. Wenxia Dong, Zhongping Li, Wen Wen, Sisi Feng, Yuanjian Zhang, Guangming Wen.  (2021)  PCN-222@g-C3N4 cathodic materials for “signal-off” photoelectrochemical sensing of kanamycin sulfate.  RSC Advances,  11  (45): (28320-28325).  [PMID:35480742] [10.1039/D1RA04275K]

23. Ying Liu, Jingfeng Gao, Yuwei Wang, Wanjun Duan, Jie Liu, Yi Zhang, Haoran Zhang, Mingyan Zhao.  (2021)  The removal of antibiotic resistant bacteria and genes and inhibition of the horizontal gene transfer by contrastive research on sulfidated nanoscale zerovalent iron activating peroxymonosulfate or peroxydisulfate.  JOURNAL OF HAZARDOUS MATERIALS,      [PMID:34482079] [10.1016/j.jhazmat.2021.126866]

24. Zhongnan Huang, Zhenglian Li, Yao Chen, Luyao Xu, Qianlong Xie, Haohua Deng, Wei Chen, Huaping Peng.  (2021)  Regulating Valence States of Gold Nanocluster as a New Strategy for the Ultrasensitive Electrochemiluminescence Detection of Kanamycin.  ANALYTICAL CHEMISTRY,      [PMID:33661613] [10.1021/acs.analchem.1c00063]

25. Li-Bin Guo, Chen-Yuan Zhu, Yi-Bei Wu, Xiao-Man Fan, Ye-Wang Zhang.  (2021)  A novel chondroitin AC lyase from Pedobacter xixiisoli: Cloning, expression, characterization and the application in the preparation of oligosaccharides.  ENZYME AND MICROBIAL TECHNOLOGY,      [PMID:33812567] [10.1016/j.enzmictec.2021.109765]

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43. Xiaoli Qin, Wenjuan Guo, Huijing Yu, Juan Zhao, Meishan Pei.  (2015)  A novel electrochemical aptasensor based on MWCNTs–BMIMPF6 and amino functionalized graphene nanocomposite films for determination of kanamycin.  Analytical Methods,  7  (13): (5419-5427).  [PMID:] [10.1039/C5AY00713E]

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45. Yangyinchun Bao, Yidan Sang, Xuemei Yan, Mengyang Hu, Na Wang, Yafei Dong, Luhui Wang.  (2024)  A enzyme-free fluorescence quenching sensor for amplified detection of kanamycin in milk based on competitive triggering strategies.  RSC Advances,  14  (27): (19076-19082).  [PMID:38873552] [10.1039/D4RA01703J]

46. Longjie Xie, Cong Fan, Yang Liu, Qin Chen, Xian Chen.  (2024)  A fluorescent aptasensor for enzyme-free and sensitive detection of kanamycin based on entropy-driven strand displacement reaction.  ANALYTICA CHIMICA ACTA,      [PMID:38740459] [10.1016/j.aca.2024.342659]

47. Runze Zhang, Kexin Liu, Fangran Jia, Tianci Xu, Yongjie Yang.  (2024)  A label-free colorimetric aptasensor for rapid multiplex detection of leuco-malachite green and leuco-crystal violet.  Analytical Methods,      [PMID:39651551] [10.1039/D4AY01849D]

48. Zixuan Zhou, Yuhan Jiang, Xin Luo, Ying Zhang, Lei Wang, Yaguang Sun, Mingchang Zhu, Shuangyan Wu.  (2024)  A novel coordination polymer array sensor for differential detection of nitroimidazole antibiotics.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2024.112405]

49. Si Long, Zhi Chen, Xin Ju, Liangzhi Li.  (2025)  Application of microbial glucose isomerases in a cascade to convert xylose to rare sugars.  Molecular Catalysis,      [PMID:] [10.1016/j.mcat.2025.114862]

50. Li Yang-Nan, Zhu Chen-Yuan, Xu Chen-Lu, Yu Shen, Huan Tong, Zhang Ye-Wang.  (2024)  Cloning, expression, and characterization of a heparinase III coupled with heparinase I for enzymatic depolymerization of heparin.  WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY,  41  (1): (1-12).  [PMID:39710799] [10.1007/s11274-024-04225-2]

51. Chong Zhang, Jinglin Liao, Yuancong Li, Shuli Liu, Mengting Li, Di Zhang, Zhenyu Wang, Dong Liu, Hanjie Ying.  (2024)  Continuous Secretion of Human Epidermal Growth Factor Based on Escherichia coli Biofilm.  Fermentation-Basel,  10  (4): (202).  [PMID:] [10.3390/fermentation10040202]

52. Tingting Xu, Dan Fang, Tianqi Xu, Xiuying Tao, Zhiqiang Wang, Yuan Liu.  (2025)  Exercise-driven gut microbiota alterations enhance colonization resistance against methicillin-resistant Staphylococcus aureus.  Cell Reports,      [PMID:40080501] [10.1016/j.celrep.2025.115424]

53. Liu Shanshan, Wang Yiran, Xiang Fan, Chen Yanmei, Li Jing, Lin Junqi, Ruan Zhijun.  (2024)  Fluorescent and polarity-switchable photoelectrochemical dual-mode homogeneous sensing platform for ultrasensitive kanamycin detection based on EXO III–driven signal amplification.  MICROCHIMICA ACTA,  191  (10): (1-12).  [PMID:39284945] [10.1007/s00604-024-06679-5]

54. Tai Ye, Long Bai, Jinsong Yu, Weiyan Shi, Min Yuan, Juncheng Wang, Hui Cao, Liling Hao, Xiuxiu Wu, Fengqin Yin, Fei Xu.  (2024)  Fluorescent nanozyme for the dual-mode detection of tetracycline: Aggregation-induced luminescence and boosting peroxidase-like activity.  FOOD CONTROL,      [PMID:] [10.1016/j.foodcont.2024.111109]

55. Chen-Lu Xu, Chen-Yuan Zhu, Yang-Nan Li, Jian Gao, Ye-Wang Zhang.  (2024)  Heparinase III with High Activity and Stability: Heterologous Expression, Biochemical Characterization, and Application in Depolymerization of Heparin.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:38307881] [10.1021/acs.jafc.3c07197]

56. Zhaofeng Wang, Hui Xu, Lihua Wang, Xinxiang Zheng, Tengzhi Zhao, Bowen Qu, Hua Wang.  (2025)  Highly-sensitive ratiometric determination of tetracyclines and smartphone-assisted visual assay by carrot-derived nitrogen-doped carbon dots-europium ion dual-emission fluorescence probe.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2025.113398]

57. Xin Yuan Li, Qing Hong Long, Zhoujian Pan, Xiao Han Ma, Chunhua Xia, Xi Mai, Na Li.  (2024)  Integrated Eu3+ loaded covalent organic framework with smartphone for ratiometric fluorescence detection of tetracycline.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,      [PMID:38852306] [10.1016/j.saa.2024.124610]

58. Xinyue Yin, Qi Pu, Chumeng Wang, Yuhong Xiang, Nengsheng Ye.  (2025)  Label-free fluorescence displacement sensors based on split aptamers and Thioflavin T for the rapid and sensitive detection of kanamycin in milk.  Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment,      [PMID:39899703] [10.1080/19440049.2025.2459219]

59. Wanling Cui, Churuo Hu, Rui Zhu, Dewen Qiu, Ruihong Gong, Rui Wang, Qiang Li, Tingting Yan, Chonghui Li, Mei Qiao, Shicai Xu.  (2024)  Low-background fluorescent biosensor based on graphene oxide and aptamer biorecognition for sensitive detection of kanamycin.  JOURNAL OF FOOD COMPOSITION AND ANALYSIS,      [PMID:] [10.1016/j.jfca.2024.106261]

60. Wanjun Long, Huanhuan Lu, Yulong Han, Hengye Chen, Wei Lan, Yuanbin She, Haiyan Fu.  (2025)  Machine learning-assisted smartphone-based fluorescence visual sensing platform for ultrasensitive detection of chlortetracycline.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2025.137241]

61. Xiaoyu Fu, Jingfeng Gao, Qian Wang, Hao Chen, Ying Liu, Liqin Zeng, Yukun Yuan, Hongxin Xu.  (2024)  Mechanisms on the removal of gram-negative/positive antibiotic resistant bacteria and inhibition of horizontal gene transfer by ferrate coupled with peroxydisulfate or peroxymonosulfate.  JOURNAL OF HAZARDOUS MATERIALS,      [PMID:38615644] [10.1016/j.jhazmat.2024.134254]

62. Bingbing Xia, Zhiwei Li, Jinao Wei, Ganpeng Hu, Jingwen Yang, Hongbin Zhang, Xueqin Hu.  (2024)  Modification of the Loop Region Near the Substrate Tunnel to Alter the Hydrolytic Process of Dextranase.  JOURNAL OF BIOTECHNOLOGY,      [PMID:38185430] [10.1016/j.jbiotec.2024.01.003]

63. Zhu Li, Kexin Mao, Lin Liu, Shengyun Xu, Min Zeng, Yu Fu, Jintao Huang, Tingting Li, Guoan Gao, Zhao-Qian Teng, Qinmiao Sun, Dahua Chen, Ying Cheng.  (2024)  Nuclear microRNA-mediated transcriptional control determines adult microglial homeostasis and brain function.  Cell Reports,      [PMID:38489263] [10.1016/j.celrep.2024.113964]

64. Yali Qiao, Yujing Han, Jinfang Shan.  (2024)  One-Pot Synthesis of Ratiometric Fluorescent Europium (III)−Functionalized Polymer Nanodots for Amplified Detection of Tetracyclines.  ACS Applied Nano Materials,      [PMID:] [10.1021/acsanm.4c04446]

65. Yating Zhong, Keying Zhang, Xinru Wang, Haibo Liang, Ying Yu, Manli Guo, Yujuan Cao, Bixia Lin.  (2025)  Ratiometric fluorescence analysis of tetracycline by dual-ligand europium-based metal-organic framework.  FOOD CHEMISTRY,      [PMID:39952183] [10.1016/j.foodchem.2025.143360]

66. Lixin Kang, Haoran Li, Kexin Lin, Shen Hu, Song Liu, Yuben Qiao, Ying Wang, Aitao Li.  (2025)  Regioselectivity Switching in CYP107Pdh-Catalyzed VD3 Hydroxylation: A Structure-Guided Approach To Improve Calcidiol Production.  ACS Catalysis,      [PMID:] [10.1021/acscatal.5c00444]

67. Qian Wang, Jingfeng Gao, Hao Chen, Ying Liu, Xiaoyu Fu, Jiawen An, Hanyi Wang, Yuxuan Wang.  (2024)  Removal of antibiotic resistant bacteria by the coupled system of ferrous ion activated peroxymonosulfate (PMS) and sodium percarbonate (SPC): Performance and mechanisms.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2024.152046]

68. Shuyue Xiong, Zijian Wu, Fang Li, Pei Zhao, Haitao Li, Huanxin Bao, Xu Yang.  (2024)  Self-assembled sensing interface based on specific aptamer functionalized Ti3C2 MXene for ultrasensitive antibiotic detection in milk.  LWT-FOOD SCIENCE AND TECHNOLOGY,      [PMID:] [10.1016/j.lwt.2024.116186]

69. Lianshuang Jiang, Chenghui Li, Xiandeng Hou.  (2024)  Smartphone-based dual inverse signal MOFs fluorescence sensing for intelligent on-site visual detection of malachite green.  TALANTA,      [PMID:38604043] [10.1016/j.talanta.2024.126039]

70. Maoxia Ran, Haiyan Qi, Tao Jing, Jun Li, Wenbo Li, Jiayu Zhang, Chao Luo, Xiaochen Zhu, Yang Gao.  (2024)  Ultrasensitive pH-switchablenitrogen doped carbon dots for MnO4− detection and fluorescent anti-counterfeiting.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,      [PMID:39094272] [10.1016/j.saa.2024.124907]

71. Yaozhang Yang, Yuanyuan Wang, Fengyi Zeng, Yuhao Chen, Zhiyi Chen, Fei Yan.  (2024)  Ultrasound-visible engineered bacteria for tumor chemo-immunotherapy.  Cell Reports Medicine,      [PMID:38640931] [10.1016/j.xcrm.2024.101512]

72. Li Fang, Luo Mingming, Tan Yijun, Liu Ruowei, Xu Longping, Zhao Pei, Wu Zijian.  (2025)  A dual-mode electrochemical and fluorescence aptasensor based on CDs@Cu/Al-MOF and Ti3C2 for the detection of kanamycin in milk.  MICROCHIMICA ACTA,  192  (8): (1-13).  [PMID:40707684] [10.1007/s00604-025-07393-6]

73. Bo Zhang, Tong Wang, Siyu Ni, Yaping Zong, Nan Wang, Yunlong Si, Yong Li.  (2025)  A refolding tag for purifying bioactive recombinant proteins from E. coli inclusion bodies.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:40834961] [10.1016/j.ijbiomac.2025.146981]

74. Yaran Wang, Fan Wu, Lei Hua, Chang Gao, Siran Wang, Yong Liu, Yijin Ren, Linqi Shi, Henny C. van der Mei, Yuanfeng Li.  (2025)  Bimetal-Phenolic Framework to Combat Bacterial Infections via Synergistic Biofilm Dispersal, Bacterial Killing and Immune Modulation.  Advanced Science,      [PMID:40959855] [10.1002/advs.202513863]

75. Wenwei Tang, Meihuan Tong, Hui Liao, Peiqi Zhang, Xinping Zeng.  (2025)  Construction of engineering bacteria for manganese oxidation and degradation of aureomycin by biogenic manganese oxides.  Journal of Environmental Chemical Engineering,      [PMID:] [10.1016/j.jece.2025.119402]

76. Yuxi Xiao, Zhi Li, Yanping Yu, Yuchen Xie, Li Xu, Heng Zheng.  (2025)  Carbon dots derivatizing from kanamycin with selective antimicrobial activity against Gram-negative bacteria and reactive oxygen species scavenging ability.  COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,      [PMID:] [10.1016/j.colsurfa.2025.138471]

77. Yuke Qin, Shuting Hu, Yibin Yang, Xiaoqiang Jia.  (2025)  Whole-cell biosensors with regulatory circuits based on a synthetic dual-input promoter enabling the highly sensitive detection of ultra-trace Cd2+.  Synthetic and Systems Biotechnology,      [PMID:41079772] [10.1016/j.synbio.2025.09.008]

78. Daoyan Tang, Minggui Wang, Dan Wang, Danni Yang, Yi Cai, Tao Luo, Jianqing He, Qinglan Wang.  (2025)  Ultra-high field strength electroporation enables efficient DNA transformation and genome editing in nontuberculous mycobacteria.  Microbiology Spectrum,  13  (10):   [PMID:40920009] [10.1128/spectrum.01944-25]

79. Zhao Tengzhi, Wang Zhaofeng, Zhang Runke, Xu Hui, Wang Hua, Yu Ying.  (2025)  Carrot-Derived Nitrogen-Doped Dual-Emission Carbon Dots for Ratiometric Detection of Tetracycline and Oxytetracycline.  JOURNAL OF FLUORESCENCE,      [PMID:40924358] [10.1007/s10895-025-04531-4]

80. Qi Nie, Jingjing Deng, Bing Xie, Tianshu Zhou.  (2023)  Enhanced-sensitivity and rapid-response for the detection of kanamycin based on ethanol-assisted AIEE effect in silver-doped gold nanoclusters.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2023.108831]

81. Yafang Liu, Ming Yi, Yan Wang.  (2023)  Boronate ester-based pH stimulated bactericide armoring for efficient fouling control of LNF membranes.  JOURNAL OF MEMBRANE SCIENCE,      [PMID:] [10.1016/j.memsci.2023.121662]

82. Wenjuan Dong, Lu Wang, Rongrong Zhang, Chaochao Wen, Ren Su, Xiaojuan Gong, Wenting Liang.  (2023)  High luminescent N,S,P co-doped carbon dots for the fluorescence sensing of extreme acidity and folic acid.  DALTON TRANSACTIONS,  52  (19): (6551-6558).  [PMID:37185994] [10.1039/D3DT00560G]

83. Jing Han, Pengfei Ma, Imran Mahmood Khan, Yin Zhang, Zhouping Wang.  (2023)  Study of binding mechanism of aptamer to kanamycin and the development of fluorescent aptasensor in milk detection.  TALANTA,      [PMID:37116356] [10.1016/j.talanta.2023.124530]

84. Yi Zhang, Qingbo Deng, Chang Tang, Minglu Zhang, Zilong Huang, Zhifeng Cai.  (2022)  Fluorescent folic acid-capped copper nanoclusters for the determination of rifampicin based on inner filter effect.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,      [PMID:36228492] [10.1016/j.saa.2022.121944]

85. Hui Yang, Yunlong Wei, Xiufang Yan, Chao Nie, Zhenchun Sun, Likai Hao, Xiankun Su.  (2022)  High-Efficiency Utilization of Waste Tobacco Stems to Synthesize Novel Biomass-Based Carbon Dots for Precise Detection of Tetracycline Antibiotic Residues.  Nanomaterials,  12  (18): (3241).  [PMID:36145029] [10.3390/nano12183241]

86. Zhiwen Li, Jiyue Zhang, Qiyao Sun, Wenwen Shi, Tingxian Tao, Yingqiang Fu.  (2022)  Moxifloxacin detection based on fluorescence resonance energy transfer from carbon quantum dots to moxifloxacin using a ratiometric fluorescence probe.  NEW JOURNAL OF CHEMISTRY,  46  (9): (4226-4232).  [PMID:] [10.1039/D1NJ05961K]

87. Yimeng Sun, Cong Ma, Man Wu, Chunping Jia, Shilun Feng, Jianlong Zhao, Lijuan Liang.  (2021)  Sensitivity of photoelctrocehmical aptasensor using spiral nanorods for detecting antiobiotic levels in experimental and real samples.  TALANTA,      [PMID:34736667] [10.1016/j.talanta.2021.122930]

88. Min Lin, Hong Yan Zou, Tong Yang, Ze Xi Liu, Hui Liu, Cheng Zhi Huang.  (2016)  An inner filter effect based sensor of tetracycline hydrochloride as developed by loading photoluminescent carbon nanodots in the electrospun nanofibers.  Nanoscale,  8  (5): (2999-3007).  [PMID:26781447] [10.1039/C5NR08177G]

89. Lina Gao, Junfei Wu, Hai-Bo Liu, Qian Zhao, Jing Wang.  (2025)  Metal-mediated chitosan@mesoporous silica-based ultrasensitive fluorescent probe for the ratiometic and colorimetric detection of tetracycline antibiotics.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:39924023] [10.1016/j.ijbiomac.2025.140779]

90. Weigang Wang, Na Yang, Liangliang Wang, Yuanxiang Zhu, Xiao Chu, Weijie Xu, Yawei Li, Yihai Xu, Lina Gao, Beibei Zhang, Guoqiang Zhang, Qinmiao Sun, Weihong Wang, Qiang Wang, Wenxin Zhang, Dahua Chen.  (2024)  The TET-Sall4-BMP regulatory axis controls craniofacial cartilage development.  Cell Reports,      [PMID:38427557] [10.1016/j.celrep.2024.113873]

91. Feiyu Yu, Shuyao Zhu, Qingyang Lv, Dan Fang, Haijie Zhang, Zhiqiang Wang, Yuan Liu.  (2025)  Lon dysfunction-mediated collateral sensitivity drives effective antibiotic combination therapies against tigecycline-resistant pathogens.  Cell Reports,      [PMID:40650911] [10.1016/j.celrep.2025.115987]

92. Fang Li, Shuyue Xiong, Yijun Tan, Mingming Luo, Zijian Wu.  (2025)  A simple self-assembly aptasensor for ultrasensitive detection of kanamycin based on carbon dots and Ti3C2 MXene nanocomposite.  RSC Advances,  15  (14): (11271-11282).  [PMID:40206359] [10.1039/D5RA01006C]

93. Shunyi Zhou, Huijie Lu, Shuyan Wang, Lizhong Zhu.  (2025)  Reactive oxygen species as quantitative indicator of antibiotic resistance in environmental bacteria.  Journal of Environmental Sciences,      [PMID:] [10.1016/j.jes.2025.04.048]

94. Hui Ma, Jiancheng Zhao, Wenbo Dong, Gang Wei, Pan Zhou, Xingshun Cong, Kefeng Wu, Yingxiong Wang, Jing Liao, Qi Zhao.  (2025)  High-resolution pure shift NMR spectroscopy for fast structural analysis of complex drug compounds with overlapping multiplets.  JOURNAL OF MOLECULAR STRUCTURE,      [PMID:] [10.1016/j.molstruc.2025.142492]

95. Yun Cao, Shuo Zhou, Bei-Bei Yin, Yan Wang.  (2025)  A cadmium-based coordination polymer as multifunctional fluorescent sensor for simultaneous detection of heavy metal ions and antibiotics in water.  INORGANICA CHIMICA ACTA,      [PMID:] [10.1016/j.ica.2025.122727]

96. Xiaofeng Yang, Zhanglin Lin, Ya Xiang, Zisha Lao.  (2025)  Antibody Purification Using Spy Chemistry.  Bio-protocol,  15  (8): (e5286).  [PMID:40291418] [10.21769/BioProtoc.5286]

97. Mingming Luo, Fang Li, Panpan Dong, Yijun Tan, Ruowei Liu, Longping Xu, Pei Zhao, Zijian Wu.  (2025)  Ultrasensitive electrochemical aptasensor based on the Cu/Al-MOF Decorated Ti3C2 for Kanamycin detection in milk and honey.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2025.114073]

98. Meng You, Xinxin Zhang, Yanli Zhang, Jialu Sun, Qiuyan Sha, Mengdie Wang, Huaiyue Zhang, Di Shen, Yunlong Zhang, Ning Wang, Ying Liu, Yu Liu.  (2025)  Impact of mechanical stress on human transthyretin protein amyloid formation.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:40527379] [10.1016/j.ijbiomac.2025.145291]

99. Naying Zhang, Zefeng Ren, Dongsheng Wei, Meng Yang, Meng Niu, Chunxiao Shen, Xuanyan Jin, Maolin Wei, Jaehwan Choi, Myeongsam Park, Zhengqun Li.  (2025)  Discovery, expression, and characterization of highly tolerant superoxide dismutases from extremophiles for potential industrial applications.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:40541892] [10.1016/j.ijbiomac.2025.145272]

100. Wang Li, Song YingJie, Guo Yi, Chen Guobing, Zhang Hua, Liang Changhai.  (2025)  Modification of Nitrile Hydratase by Substrate Channel Engineering Regulates Monocyanamide Synthesis.  CATALYSIS LETTERS,  155  (7): (1-12).  [PMID:] [10.1007/s10562-025-05096-4]

101. Lijun Zhu, Wenjie Huang, Jingjing Shi, Fei Li, Xiuxia Sun, Jianxi Xiao.  (2025)  Multipotent anti-aging recombinant human elastin: Counteracting zebrafish caudal fin shrinkage and D-galactose-induced intrinsic skin aging in mice.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:40571014] [10.1016/j.ijbiomac.2025.145467]

102. Yun Cao, Ke-Xin Yuan, Yan Wang.  (2025)  “Turn-off” Cd-MOF fluorescence sensor for identification and detection of Fe3+, Cr6+ and antibiotics in aqueous solutions.  DYES AND PIGMENTS,      [PMID:] [10.1016/j.dyepig.2025.112999]

103. Huanhuan Lu, Yulong Han, Hengye Chen, Wei Lan, Li Yang, Xinming Lv, Wanjun Long, Haiyan Fu.  (2025)  Machine learning-assisted fluorescent sensing platform based on bovine serum albumin-capped gold‑silver nanoclusters for visual quantitative of chlortetracycline.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2025.115209]

104. Jiashi Li, Zhong Lu, Xiaoli Zeng, Hanxiao Zhang, Haixia Lu, Lifang Feng, Junli Zhu.  (2025)  Efficient quenching activity and thermostability of N-acyl homoserine lactonase AiiA against fish spoilage mediated by Pseudomonas fluorescens via rational design.  FOOD MICROBIOLOGY,      [PMID:41478679] [10.1016/j.fm.2025.105002]

105. Nannan Wei, Yuchen Zhang, Xinyu Tian, Linyan Yao, Jianxi Xiao.  (2025)  Injectable self-assembled recombinant collagen nanofiber restores ECM homeostasis for photoaged skin repair.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:41412246] [10.1016/j.ijbiomac.2025.149710]

106. Lili Liu, Xingtong Liu, Linna Li, Yandi Hui, Jiajia Lu, Zhen Li, Fujun Yao, Xiaofeng Kang, YanLi Guo.  (2025)  Asymmetrically modified hydrogel nanochannel biosensor for label-free and selective kanamycin monitoring.  TALANTA,      [PMID:40684741] [10.1016/j.talanta.2025.128590]

107. Zhitan Huang, Tao Liu, Jiaqi Geng, Siyue Zhang, Neha, Miantai Ye, Wei Sun.  (2026)  Molecularly imprinted electrochemical sensor based on AuNPs-nitrogen doped graphene-MXene nanocomposite for the detection of kanamycin in milk.  JOURNAL OF FOOD COMPOSITION AND ANALYSIS,      [PMID:] [10.1016/j.jfca.2026.108868]

108. Yulong Han, Huanhuan Lu, Haili Liu, Hengye Chen, Wei Lan, Xinming Lv, Wanjun Long, Haiyan Fu.  (2026)  Machine learning-assisted ratiometric fluorescent sensing platform based on antenna effect in Tb-doped metal–organic framework for visual quantification of enoxacin.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,      [PMID:41605080] [10.1016/j.saa.2026.127517]

109. Yang Jiating, Wang Xinle, Chen Dongye, Wang Ning, Liu Xiaokun, Xu Zhe.  (2026)  Enrichment and analysis of aminoglycoside antibiotics in honey using hydrophilic magnetic graphene composites combined with high performance liquid chromatography mass spectrometry.  Journal of Food Measurement and Characterization,      [PMID:] [10.1007/s11694-026-04047-w]

110. Nannan Wei, Yuchen Zhang, Xinyu Tian, Linyan Yao, Jianxi Xiao.  (2026)  Injectable Crosslinked Recombinant Collagen Nanofiber Implants Enable Robust Regenerative Repair of Photoaged Skin.  Biomaterials Science,      [PMID:41626806] [10.1039/D5BM01715G]

111. Dian Li, Shangbin Kao, Mengwei Li, Yuan Qin, Xiumei Zhou, Xueqin Zhao, Jie Chen, Biao Huang.  (2026)  AlphaLICA-Based Homogeneous Immunoassay for Highly Sensitive Detection of Streptomycin in Infant Formula.  Analytical Methods,      [PMID:41710976] [10.1039/D5AY02160J]

112. Feng Xu, Hao Gao, Rong Ben, Kaihao Hu, Yuan Wang, Ali Mohsin, Yuanxin Guo, Xu Li, Haifeng Hang, Ju Chu, Xiwei Tian.  (2026)  Systematic engineering of Micromonospora echinospora cell factory for gentamicin C1a overproduction.  TRENDS IN BIOTECHNOLOGY,      [PMID:41558881] [10.1016/j.tibtech.2025.12.006]

113. Ning Wang, Meiling Jin, Zixuan Zhu, Yuxin Wang, Xinyu Li, Jing Xu, Shijunyi Cheng, Yuanying Zhu, Ruiqi Wang, Tong Xu, Furong Yin, Xinyue Li, Yue Ke, Haitao Yue.  (2026)  Ecological distribution and functional characterization of polyethylene-degrading enzymes from diverse metagenomes.  SCIENCE OF THE TOTAL ENVIRONMENT,      [PMID:41671813] [10.1016/j.scitotenv.2026.181486]

114. Wei Nannan, Zhang Yuchen, Tian Xinyu, Yao Linyan, Xiao Jianxi.  (2026)  Synergistic self-assembly and crosslinking yield a durable, bioactive, and injectable recombinant collagen implant for photoaging therapy.  Regenerative Biomaterials,      [PMID:] [10.1093/rb/rbag026]

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