What are the advantages of Friedel Crafts acylation?
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What are the advantages of Friedel Crafts acylation?
·Reviewed·Published ·Updated ·8 min read
What are the advantages of Friedel Crafts acylation?
Compared to Friedel-Crafts alkylation, Friedel-Crafts acylation has several advantages: better control of the reaction products, while the acyl ions have a positive charge on the carbon, and are resonance stable, so there is no chance of rearrangement. Using Clemens reduction, the ketones obtained can be reduced to alkyl groups.
Da — when not otherwise indicated, molecular weight units are daltons. Mw — weight-average molecular weight. Mn — number-average molecular weight.
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Aladdin Scientific. "What are the advantages of Friedel Crafts acylation?" Aladdin Knowledge Base, updated Oct 9, 2023. https://www.aladdinsci.com/us_en/faqs/what-are-the-advantages-of-friedel-crafts-acylation-en.html
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