Kolliphor® HS 15 , CAS No.70142-34-6

CAS: 70142-34-6 Cat. No.: K487242 EC Number: 680-598-3 PubChem CID: 135327775

Synonyms

Solutol® HS 15 | Macrogol (15)-hydroxystearate | Polyethylene glycol (15)-hydroxystearate | Polyoxyethylated 12-hydroxystearic acid

Storage

Room temperature

Overview

Kolliphor® HS 15, a pH-independent non-ionic surfactant, is an effective solubilizer and emulsifying agent. It is soluble in aqueous media and polar organic solvents however it is not soluble in apolar solvents. Its structure has 12-hydroxystearic acid (lipophilic moiety) and polyethylene glycol (hydrophilic moiety).

Application：

Kolliphor® HS 15 has been used:

in dissolving dexamethasone (DEX) to intraperitoneally inject the mice to test its grip strength to measure the muscle force

in roflumilast preparation to treat rabbits and guinea pigs to study the mechanisms and pharmacological sensitivity of ozone-induced hypertussive responses

to dissolve finerenone for oral application in in vivo-studies

Advantages and Features：

Low histamine release for fewer side-effects

Offers thermal stability, suitable for heat sterilization      

Has lower hemolytic activity than other polyoxyethylene-based surfactants      

Allows to formulate poorly soluble APIs in oral and parenteral dosage forms

Specifications

Synonyms

Solutol® HS 15 | Macrogol (15)-hydroxystearate | Polyethylene glycol (15)-hydroxystearate | Polyoxyethylated 12-hydroxystearic acid

Biochemical and Physiological Mechanisms

Kolliphor® HS 15 is mainly used as a solubilizer in parenteral and oral formulations. It is preferred for in vitro screening and in vivo efficacy studies of compounds. Kolliphor® HS 15 is also used in ophthalmic, macromolecule, suppository, and protein fo

Legal Information

Kolliphor is a registered trademark of BASFSolutol is a registered trademark of BASF SE

Storage

Room temperature

Note

Kolliphor HS 15 is a non-ionic detergent obtained by reacting 15 moles of ethylene oxide with 1 mole of 12-hydroxy stearic acid.', '

Names and Identifiers

• Pubchem Sid: 504773207
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504773207
• Alternate CAS: 61909-81-7、105109-85-1、6284-41-9
• PubChem CID: 135327775

References

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2. Jingwen Luo, Zhiwei Zhang, Yingchun Zeng, Yanming Dong, Lixin Ma.  (2021)  Co-encapsulation of collagenase type I and silibinin in chondroitin sulfate coated multilayered nanoparticles for targeted treatment of liver fibrosis.  CARBOHYDRATE POLYMERS,      [PMID:33858569] [10.1016/j.carbpol.2021.117964]

3. Chenglong Li, Shuhao Xu, Xin Li, Huaiyu Su, Can Qian, Yingying Hou, Sanjun Shi.  (2025)  A Transformable Nanoplatform Precisely Positions Fibroblast-Like Synoviocytes via FAP-α for Improved Rheumatoid Arthritis Therapy.  Advanced Healthcare Materials,      [PMID:40931560] [10.1002/adhm.202503277]

4. Xin Zhang, Zutong Cui, Wenming Liang, Zihan Zhang, Jianming Sun, Liming Gao, Ming Shi, Zhiwei Liu, Kun Li, Jian Li.  (2026)  Disrupting the Fortress: A Biomimetic Nano-Dual-Sensitizer Remodels Tumor Microenvironment via Dual HIF-1α Inhibition for Robust Photo-Immunotherapy.  ACS Applied Materials & Interfaces,      [PMID:] [10.1021/acsami.5c24160]