Koumine can induce apoptosis of LoVo cells in a time-dependent manner and inhibit the DNA synthesis in LoVo cells, thereby blocking the cell cycle from G1 to S phase. Koumine has a significant analgesic effect in rodent behavioral models of inflammatory and neuropathic pain, and that the reduction in neuropathic pain may be associated with the upregulation of allopregnanolone in the spinal cord. Koumine has therapeutic effect against psoriasis, which is related to the inhibition of epidermal cell proliferation, promoting the formation of granular cells and decreasing the serum level of IL- Koumine can significantly reduce the damage to axon and myelin sheath of the sciatic nerve and increase sensory nerve conduction velocity , without affecting body weight and blood glucose, these findings encourage the use of koumine in the treatment of diabetic neuropathy. Koumine has antineoplastic effect, may be a future breast cancer chemotherapeutic agent. Koumine may produce anxiolytic-effect by increasing the levels of pregnenolone and allopregnenolone in hippocampus.
| ALogP | 1.879 |
|---|---|
| hba_count | 2 |
| Rotatable Bond | 1 |
| Canonical Smiles | CN1CC2(C3CC4C5=NC6=CC=CC=C6C52CC1C3CO4)C=C |
|---|---|
| IUPAC Name | (1R,10R,12S,15S,16R,17S)-15-ethenyl-13-methyl-19-oxa-3,13-diazahexacyclo[14.3.1.02,10.04,9.010,15.012,17]icosa-2,4,6,8-tetraene |
| InChIKey | VTLYEMHGPMGUOT-FXWNUWCSSA-N |
| INCHI | 1S/C20H22N2O/c1-3-19-11-22(2)16-9-20(19)13-6-4-5-7-15(13)21-18(20)17-8-14(19)12(16)10-23-17/h3-7,12,14,16-17H,1,8-11H2,2H3/t12-,14+,16-,17+,19-,20+/m0/s1 |
| Isomeric SMILES | CN1C[C@]2([C@@H]3C[C@@H]4C5=NC6=CC=CC=C6[C@]52C[C@H]1[C@H]3CO4)C=C |
| Molecular Weight | 306.4 |
| Reaxy-Rn | 25328208 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=25328208&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
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View spec sheet →| DMSO(mg / mL) Max Solubility | 15 |
|---|---|
| DMSO(mM) Max Solubility | 48.9553771084918 |
