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· · COA & SDS available for every product · Same-day shipping on in-stock items L-(-)-threo-3-Hydroxyaspartic acid - Moligand™, ≥97% , CAS No.7298-99-9
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥97% Synonyms
DL-THA | rel-(2S,3S)-2-Amino-3-hydroxysuccinic acid | .BETA.-HYDROXYASPARTIC ACID, L-THREO- | Q4634147 | DTXSID301017241 | NCGC00024486-02 | AKOS015896769 | EU-0100564 | NCGC00169005-01 | beta-Hydroxyaspartic acid, l-threo-
Shipped In
Ice chest + Ice pads
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Why this grade Moligand™, ≥97% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
L-threo-3-Hydroxyaspartic acid is a potent EAAT inhibitor with Kis of 11, 19 and 14 μM for EAAT1, EAAT2 and EAAT3, respectively in HEK293 cell lines.
Specifications Synonyms
DL-THA | rel-(2S, 3S)-2-Amino-3-hydroxysuccinic acid | .BETA.-HYDROXYASPARTIC ACID, L-THREO- | Q4634147 | DTXSID301017241 | NCGC00024486-02 | AKOS015896769 | EU-0100564 | NCGC00169005-01 | beta-Hydroxyaspartic acid, l-threo-
Specifications & Purity
Moligand™, ≥97%
Biochemical and Physiological Mechanisms
Potent, competitive, transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor. Potentiates L-glutamate and L-aspartate induced neuronal excitation. Shows neuronal excitotoxic effects in vivo.
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Note
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Names and Identifiers Canonical Smiles C(C(C(=O)O)O)(C(=O)O)N IUPAC Name (2S,3S)-2-amino-3-hydroxybutanedioic acid InChIKey YYLQUHNPNCGKJQ-LWMBPPNESA-N INCHI 1S/C4H7NO5/c5-1(3(7)8)2(6)4(9)10/h1-2,6H,5H2,(H,7,8)(H,9,10)/t1-,2-/m0/s1 Isomeric SMILES [C@H]([C@@H](C(=O)O)O)(C(=O)O)N Molecular Weight 149.10 Reaxy-Rn 1101761 Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1101761&ln=
Documentation 📋 Safety Data Sheet (SDS) Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS → ✅ Certificate of Analysis (COA) Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA → 📊 Datasheet Quick-reference summary of product specifications and applications.
View datasheet → 🔬 Specification Sheet Full quality attributes and acceptance criteria for this grade.
View spec sheet →
Advanced Data Taxonomic Classification Kingdom Organic compounds Superclass Organic acids and derivatives Class Carboxylic acids and derivatives Subclass Amino acids, peptides, and analogues Intermediate Tree Nodes Amino acids and derivatives - Alpha amino acids and derivatives Direct Parent Aspartic acid and derivatives Alternative Parents L-alpha-amino acids Short-chain hydroxy acids and derivatives Beta hydroxy acids and derivatives Monosaccharides Fatty acids and conjugates Dicarboxylic acids and derivatives Alpha hydroxy acids and derivatives Secondary alcohols Amino acids Carboxylic acids Organopnictogen compounds Organic oxides Monoalkylamines Hydrocarbon derivatives Carbonyl compounds Molecular Framework Aliphatic acyclic compounds Substituents Aspartic acid or derivatives - Alpha-amino acid - L-alpha-amino acid - Beta-hydroxy acid - Short-chain hydroxy acid - Alpha-hydroxy acid - Dicarboxylic acid or derivatives - Fatty acid - Hydroxy acid - Monosaccharide - Amino acid - Secondary alcohol - Carboxylic acid - Alcohol - Organonitrogen compound - Organooxygen compound - Primary aliphatic amine - Primary amine - Hydrocarbon derivative - Organic oxide - Carbonyl group - Organopnictogen compound - Amine - Organic oxygen compound - Organic nitrogen compound - Aliphatic acyclic compound Description This compound belongs to the class of organic compounds known as aspartic acid and derivatives. These are compounds containing an aspartic acid or a derivative thereof resulting from reaction of aspartic acid at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom. External Descriptors 3-hydroxy-L-aspartic acid Data sources 1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solubility Soluble in 1eq. NaOH to 100 mM Molecular Weight 149.100 g/mol XLogP3 -4.400 Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 6 Rotatable Bond Count 3 Exact Mass 149.032 Da Monoisotopic Mass 149.032 Da Topological Polar Surface Area 121.000 Ų Heavy Atom Count 10 Formal Charge 0 Complexity 156.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 2 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 1
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