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· · COA & SDS available for every product · Same-day shipping on in-stock items LE 135 - Moligand™, ≥97%(HPLC) , CAS No.155877-83-1
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥97%(HPLC) Synonyms
4-(5,7,7,10,10-Pentamethyl-7,8,9,10-tetrahydro-5H-benzo[e]naphtho[2,3-b][1,4]diazepin-13-yl)benzoic acid | LE135 | LE-135 | BRD-K06593056-001-01-4 | CHEBI:92124 | DTXSID70439469 | SCHEMBL1132584 | J-009253 | MS-27866 | ST 24:1;O2;T | BDBM50061616 | 4-(5,7
Shipped In
Ice chest + Ice pads
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Why this grade Moligand™, ≥97%(HPLC) Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview Application：
LE 135 has been used for in vitro islet treatment.
Specifications Synonyms
4-(5, 7, 7, 10, 10-Pentamethyl-7, 8, 9, 10-tetrahydro-5H-benzo[e]naphtho[2, 3-b][1, 4]diazepin-13-yl)benzoic acid | LE135 | LE-135 | BRD-K06593056-001-01-4 | CHEBI:92124 | DTXSID70439469 | SCHEMBL1132584 | J-009253 | MS-27866 | ST 24:1;O2;T | BDBM50061616 | 4-(5, 7
Specifications & Purity
Moligand™, ≥97%(HPLC)
Biochemical and Physiological Mechanisms
Retinoic acid antagonist; displays moderate selectivity for RARβover RARα(Kivalues are 0.22 and 1.4μM respectively). Highly selective over RARγand RXRα. Inhibits human HL-60 leukemia cell differentiation induced by Am80 (IC50= 150 nM).LE135 is a retinoic
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Names and Identifiers Pubchem Sid 488196651 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488196651 Canonical Smiles CC1(CCC(C2=CC3=C(C=C21)N=C(C4=CC=CC=C4N3C)C5=CC=C(C=C5)C(=O)O)(C)C)C IUPAC Name 4-(5,7,7,10,10-pentamethyl-8,9-dihydronaphtho[2,3-b][1,4]benzodiazepin-13-yl)benzoic acid InChIKey YZZAIQOVMHVWBS-UHFFFAOYSA-N INCHI 1S/C29H30N2O2/c1-28(2)14-15-29(3,4)22-17-25-23(16-21(22)28)30-26(18-10-12-19(13-11-18)27(32)33)20-8-6-7-9-24(20)31(25)5/h6-13,16-17H,14-15H2,1-5H3,(H,32,33) Isomeric SMILES CC1(CCC(C2=CC3=C(C=C21)N=C(C4=CC=CC=C4N3C)C5=CC=C(C=C5)C(=O)O)(C)C)C WGK Germany 3 Molecular Weight 438.56 Reaxy-Rn 6943175 Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=6943175&ln=
Documentation 📋 Safety Data Sheet (SDS) Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS → ✅ Certificate of Analysis (COA) Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA → 📊 Datasheet Quick-reference summary of product specifications and applications.
View datasheet → 🔬 Specification Sheet Full quality attributes and acceptance criteria for this grade.
View spec sheet →
Advanced Data Taxonomic Classification Kingdom Organic compounds Superclass Organoheterocyclic compounds Class Benzodiazepines Subclass Dibenzodiazepines Intermediate Tree Nodes Not available Direct Parent Dibenzodiazepines Alternative Parents Alkyldiarylamines 1,4-benzodiazepines Tetralins Benzoic acids Benzoyl derivatives Ketimines Amino acids Propargyl-type 1,3-dipolar organic compounds Monocarboxylic acids and derivatives Carboxylic acids Azacyclic compounds Organopnictogen compounds Organooxygen compounds Organic oxides Hydrocarbon derivatives Molecular Framework Aromatic heteropolycyclic compounds Substituents Dibenzodiazepine - Alkyldiarylamine - 1,4-benzodiazepine - Tetralin - Benzoic acid or derivatives - Benzoic acid - Benzoyl - Tertiary aliphatic/aromatic amine - Monocyclic benzene moiety - Benzenoid - Amino acid - Ketimine - Amino acid or derivatives - Tertiary amine - Monocarboxylic acid or derivatives - Carboxylic acid - Carboxylic acid derivative - Azacycle - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Imine - Organopnictogen compound - Amine - Organic oxygen compound - Organic nitrogen compound - Organic oxide - Aromatic heteropolycyclic compound Description This compound belongs to the class of organic compounds known as dibenzodiazepines. These are compounds containing a dibenzodiazepine moiety, which consists of two benzene connected by diazepine ring. External Descriptors Not available Data sources 1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 43.86, Max Conc. mM: 100 Molecular Weight 438.600 g/mol XLogP3 7.400 Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 4 Rotatable Bond Count 2 Exact Mass 438.231 Da Monoisotopic Mass 438.231 Da Topological Polar Surface Area 52.900 Ų Heavy Atom Count 33 Formal Charge 0 Complexity 778.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 0 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 1
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