Levosimendan - Moligand™,10mM in DMSO , Troponin, cardiac muscle positive modulator, CAS No.141505-33-1, Troponin, cardiac muscle positive modulator

CAS: 141505-33-1 Cat. No.: L407801 Molecular Weight: 280.28 EC Number: 663-528-6

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

(R)-2-(2-(4-(4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)hydrazono)malononitrile

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Levosimendan is acalcium sensitizeracting through calcium-dependent binding tocardiac troponin C (cTnC), provides treatment for heart failure.
In vitro

Levosimendan is a calcium sensitizer acting through calcium-dependent binding to cardiac troponin C (cTnC). Levosimendan at 3 μM decreases the value of Ca50 from 2.73μM to 1.19 μM. levosimendan exhibits its calcium sensitizing effect through calcium-dependent binding to the N-terminal domain of cTnC. Levosimendan significantly hyperpolarizes resting potential of rat mesenteric arterial myocytes with an EC50 of 2.9 μM and maximal effect (19.5 mV) at 10 μM, probably through activation of a glibenclamide-sensitive K⁺ channel. Levosimendan has inotropic and lusitropic actions in failing human myocardium, with average maximum increase in twitch tension of 47% at a levosimendan concentration of 0.8 μM. Levosimendan causes rapid dose-dependent improvement in hemodynamic function in patients with decompensated heart failure.

In vivo

Levosimendan at low concentrations (0.03 to 0.1 μM) acts preferably as a Ca2+ sensitizer, whereas at higher concentrations (0.1 to 0.3 μmol/L) its action as a phosphodiesterase inhibitor contributes to the positive inotropic effect.
Cell Data

cell lines：A2780, A2780/cp70, 2780AD, HCT116, HT29, WIL, CALU-3, MCF7, PC3 and HS852

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

(R)-2-(2-(4-(4-methyl-6-oxo-1, 4, 5, 6-tetrahydropyridazin-3-yl)phenyl)hydrazono)malononitrile

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Levosimendan is a calcium sensitizer acting through calcium-dependent binding to cardiac troponin C (cTnC), provides treatment for heart failure.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

INHIBITOR

Mechanism of action

Troponin, cardiac muscle positive modulator

Product Properties

• ALogP: 2.3

Names and Identifiers

• Isomeric SMILES: C[C@@H]1CC(=O)NN=C1C2=CC=C(C=C2)NN=C(C#N)C#N
• WGK Germany: 3
• RTECS: TY1570210
• Molecular Weight: 280.28
• Reaxy-Rn: 6959884
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=6959884&ln=

Chemical and Physical Properties

• Specific Rotation[α]: -627° (C=0.5,THF)
• Melt Point(°C): 210-214°C