Lidocaine hydrochloride - ≥98% , CAS No.73-78-9

CAS: 73-78-9 Cat. No.: L276132 Molecular Weight: 270.8 EC Number: 200-803-8

GRADE & PURITY ≥98%

Synonyms

Rucaina hydrochloride | Xilina hydrochloride | Xyloneural | Lidocaine hydrochloride | Lidothesin | Xycaine hydrochloride | LARYNG-O-JET | Anestacon | Xylocaine Viscous | Duncaine hydrochloride | Lidothesin hydrochloride | Xylotox hydrochloride | LIDOCAINE

Storage

Protected from light,Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

Overview

Lidocaine hydrochloride (Lignocaine hydrochloride) inhibits sodium channels involving complex voltage and using dependence. Lidocaine hydrochloride decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine hydrochloride is an amide derivative and a agent to treat ventricular arrhythmia and an effective tumor-inhibitor.

Specifications

Synonyms

Rucaina hydrochloride | Xilina hydrochloride | Xyloneural | Lidocaine hydrochloride | Lidothesin | Xycaine hydrochloride | LARYNG-O-JET | Anestacon | Xylocaine Viscous | Duncaine hydrochloride | Lidothesin hydrochloride | Xylotox hydrochloride | LIDOCAINE

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

Voltage gated sodium channel blocker (IC 50 values are 42 and 210 μM for TTX-sensitive and TTX-resistant DRG channels respectively). Reduces proinflammatory cytokine production and shows anesthetic effects in vivo.

Storage

Protected from light, Store at -20°C, Desiccated

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥98%

Names and Identifiers

• Pubchem Sid: 504751061
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504751061
• Canonical Smiles: CCN(CC)CC(=O)NC1=C(C=CC=C1C)C.Cl
• IUPAC Name: 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide;hydrochloride
• InChIKey: IYBQHJMYDGVZRY-UHFFFAOYSA-N
• INCHI: 1S/C14H22N2O.ClH/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4;/h7-9H,5-6,10H2,1-4H3,(H,15,17);1H
• Isomeric SMILES: CCN(CC)CC(=O)NC1=C(C=CC=C1C)C.Cl
• Molecular Weight: 270.8
• Reaxy-Rn: 3917968
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3917968&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Class Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Amino acids and derivatives
          • Level6 Alpha amino acids and derivatives
            • Level7 Alpha amino acid amides

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Class: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Amino acids and derivatives - Alpha amino acids and derivatives
• Direct Parent: Alpha amino acid amides
• Alternative Parents: Anilides m-Xylenes N-arylamides Trialkylamines Secondary carboxylic acid amides Organopnictogen compounds Organic oxides Hydrochlorides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Alpha-amino acid amide - Anilide - N-arylamide - Xylene - M-xylene - Monocyclic benzene moiety - Benzenoid - Carboxamide group - Secondary carboxylic acid amide - Tertiary amine - Tertiary aliphatic amine - Amine - Organic oxide - Organooxygen compound - Organonitrogen compound - Organopnictogen compound - Carbonyl group - Organic nitrogen compound - Hydrocarbon derivative - Hydrochloride - Organic oxygen compound - Aromatic homomonocyclic compound
• Description: This compound belongs to the class of organic compounds known as alpha amino acid amides. These are amide derivatives of alpha amino acids.
• External Descriptors: hydrochloride

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

GAA Tclin Lysosomal alpha-glucosidase (35701 Activities)

Discover Target: GAA

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LMNA Tbio Prelamin-A/C (36751 Activities)

Discover Target: LMNA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

BLM Tchem Bloom syndrome protein (4248 Activities)

Discover Target: BLM

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SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)

Discover Target: SLCO1B1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)

Discover Target: SLCO1B3

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Associated Targets(non-human)

Plasmodium falciparum (966862 Activities)

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Canis familiaris (36305 Activities)

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Mus musculus (284745 Activities)

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Rattus norvegicus (775804 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

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Sciatic nerve (18 Activities)

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Mapt Microtubule-associated protein tau (6 Activities)

Discover Target: Mapt

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Mechanisms of Action

Chemical and Physical Properties

• Solubility: Soluble in water to 100 mM
• Sensitivity: light & Moisture sensitive
• Molecular Weight: 270.800 g/mol
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 270.15 Da
• Monoisotopic Mass: 270.15 Da
• Topological Polar Surface Area: 32.299 Ų
• Heavy Atom Count: 18
• Formal Charge: 0
• Complexity: 228.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3

References

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2. Xiaokang Guan, Qiao Lu, Xiangxu Zhao, Xiaowen Yan, Renato Zenobi.  (2023)  Spatio-Temporal Analysis of Anesthetics in Mice by Solid-Phase Microextraction: Dielectric Barrier Discharge Ionization Mass Spectrometry.  ANALYTICAL CHEMISTRY,      [PMID:37560898] [10.1021/acs.analchem.3c02123]

3. Wenjie Xu, Yu Xiao, Minzhi Zhao, Jiahui Zhu, Yu Wang, Wenbin Wang, Peng Wang, Huan Meng.  (2023)  Effective Treatment of Knee Osteoarthritis Using a Nano-Enabled Drug Acupuncture Technology in Mice.  Advanced Science,      [PMID:37555294] [10.1002/advs.202302586]

4. Yang Yang, Sun Jiaxiao, Peng Fei, Liu Haibei, Zhao Guoyan, Chen Junjie, Zhang Wensheng, Qiu Feng.  (2022)  Enhanced Antitumor Activity of Lidocaine Nanoparticles Encapsulated by a Self-Assembling Peptide.  Frontiers in Pharmacology,      [PMID:35529446] [10.3389/fphar.2022.770892]

5. Baolin Wang, Xing Chen, Zeeshan Ahmad, Jie Huang, Ming-Wei Chang.  (2019)  Engineering On-Demand Magnetic Core–Shell Composite Wound Dressing Matrices via Electrohydrodynamic Micro-Scale Printing.  ADVANCED ENGINEERING MATERIALS,  21  (10): (1900699).  [PMID:] [10.1002/adem.201900699]

6. Mao Yanan, Zhang Xiufeng, Sun Yanfang, Shen Zhong, Zhong Chao, Nie Lei, Shavandi Amin, Yunusov Khaydar E., Jiang Guohua.  (2024)  Fabrication of lidocaine-loaded polymer dissolving microneedles for rapid and prolonged local anesthesia.  BIOMEDICAL MICRODEVICES,  26  (1): (1-12).  [PMID:38189892] [10.1007/s10544-024-00695-1]

7. Xiu-Ying He, Yui-Si Yang, Yue-Xiang Zheng, Qing-Jie Xia, Hong-Zhou Yu, Xiao-Ming Zhao, Ting-Hua Wang.  (2025)  Scutellarin combined with lidocaine exerts antineoplastic effect in human glioma associated with repression of epidermal growth factor receptor signaling.  PLoS One,  20  (1): (e0318031).  [PMID:39888904] [10.1371/journal.pone.0318031]

8. Xu Wu, Zhenru Zhang, Jianquan Zhao, Baogang Wang.  (2025)  Constructing g-C3N4 nanosheets/deep eutectic solvent nanofluids as high-performance additives for polyethylene glycol.  NEW JOURNAL OF CHEMISTRY,      [PMID:] [10.1039/D5NJ02595H]

9. Jiajun Cheng, Kaixuan Teng, Yao Chen, Yunfan Chen, Xinyue Zhang, Guo Tang, Shaohua You, Long Wang, Sufang Guo, Qi An, Zeguo Feng.  (2025)  TENG Promoted Anesthetic and Protection Patch for Exposed Wound Dressing.  ChemistrySelect,  10  (30): (e06084).  [PMID:] [10.1002/slct.202406084]

10. Yanan Mao, Rui Yao, Xiufeng Zhang, Chao Zhong, Khaydar E. Yunusov, Zhong Shen, Jianwei Pan, Guohua Jiang.  (2024)  Fabrication of hollow microneedles with double-layer shell structure for rapid and prolonged local anesthesia.  JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,      [PMID:] [10.1016/j.jddst.2024.106516]

11. Shen Zhiming, Shan Yibo, Lu Yi, Zhu Jianwei, Yuan Lei, Chen Wenxuan, Sun Fei, Wang Qi, Wang Yilun, Zhang Yaojing, Xu Xiangyu, Chen Yu, Ge Wei, Chen Wei, Si Panpan, Zhang Renquan, Shi Hongcan.  (2025)  Decellularized extracellular matrix-loaded exosome hydrogel for cell-free tracheal scaffold in tracheal defect reconstruction and repair.  JOURNAL OF NANOBIOTECHNOLOGY,  23  (1): (1-19).  [PMID:40229874] [10.1186/s12951-025-03328-8]

12. Zhuohan Jing, Fangdong Long, Yuxiao Xiong, Jiaqi Liu, Zhaoju Li, Haolin Chen, Zhiming Liu, Bo Xu.  (2025)  Mitochondria-Targeted Au@Carbon Dot Nanoprobes for SERS Analysis of Drug-Induced Mitophagy.  Chemical & Biomedical Imaging,      [PMID:] [10.1021/cbmi.5c00141]

13. Dongcheng Wang, Xin Zhang, Zhen Wang, Cheng Ran, Jia Hao, Xiaobo Ma, Minghui Wang, Zhimin Zhou.  (2025)  Intratympanic dexamethasone microcrystals/lidocaine-loaded PLGA non-spherical microparticles for local drug delivery to the inner ear.  Animal Models and Experimental Medicine,      [PMID:41104516] [10.1002/ame2.70041]

14. Zhang Chi, Yang Ping, Lin Xueke, Lai Huijung, Liu Yi, Yu Shifeng, Liu Tszyam, Chen Ming, Huang Yongxiang.  (2025)  Topical delivery of Lidocaine using spicules for local anesthesia.  Drug Delivery and Translational Research,      [PMID:41402578] [10.1007/s13346-025-02030-4]

15. Zuyong Zhang, Jiawei Lu, Jiawei Zhang, Lili Huang, Huajun Feng, Hai Xiang, Bing Yu, Haifeng Zeng.  (2026)  Nanosilica-reinforced carboxymethyl cellulose/polyacrylamide hydrogel composites for sustained lidocaine release.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:41571120] [10.1016/j.ijbiomac.2026.150410]

16. Shuailei Wang, Ze Qiang Zhao, Yumiao He, Bo Zhi Chen, Hongju Liu, Xin Dong Guo, Yuguang Huang.  (2026)  Near-infrared light-activated lidocaine microneedle patch for rapid local anesthesia.  Theranostics,  16  (10): (5259).  [PMID:41993627] [10.7150/thno.129132]

17. Na Zhou, Wenjing Wang, Lian Xu, Aining Zhang, Xiaohuan Lu, Yu-Pei Chen, Shiwen Fan, Tianhao Zhang, Changjiang Yu, Xiao-Qiang Wang, Daan Fu.  (2026)  Analgesic-loaded NIR-II photothermal hydrogel for efficient anti-infection and precise pain management in wounds.  Materials Today Bio,      [PMID:] [10.1016/j.mtbio.2026.102995]