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Fibroblast growth factor receptor 2 (FGFR2)

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  1. PD173074
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    PD173074
    CAS: 219580-11-7 EC Number: 633-614-8 Formula: C28H41N7O3 Molecular Weight: 523.67
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
    In Stock Item #: P125865
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    IUPAC Name
    1-tert-butyl-3-[2-[4-(diethylamino)butylamino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]urea
    SMILES
    CCN(CC)CCCCNC1=NC2=NC(=C(C=C2C=N1)C3=CC(=CC(=C3)OC)OC)NC(=O)NC(C)(C)C
    InChIKey
    DXCUKNQANPLTEJ-UHFFFAOYSA-N
    InChI
    1S/C28H41N7O3/c1-8-35(9-2)13-11-10-12-29-26-30-18-20-16-23(19-14-21(37-6)17-22(15-19)38-7)25(31-24(20)32-26)33-27(36)34-28(3,4)5/h14-18H,8-13H2,1-7H3,show more
    Synonyms
    A25450 | SMR000568412 | BCPP000121 | MFCD08705327 | CHEBI:63448 | HMS2233G17 | NSC766908 | NSC-766908 | UNII-A4TLL863...
  2. BLU-9931, Inhibitor of fibroblast growth factor receptor 1;Inhibitor of fibroblast growth factor receptor 2;Inhibitor of fibroblast growth factor receptor 3;Inhibitor of fibroblast growth factor receptor 4
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    BLU-9931, Inhibitor of fibroblast growth factor receptor 1;Inhibitor of fibroblast growth factor receptor 2;Inhibitor of fibroblast growth factor receptor 3;Inhibitor of fibroblast growth factor receptor 4
    CAS: 1538604-68-0 Formula: C26H22Cl2N4O3 Molecular Weight: 509.384
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥97%
    In Stock Item #: B174512
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    IUPAC Name
    N-[2-[[6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl]amino]-3-methylphenyl]prop-2-enamide
    SMILES
    CC1=C(C(=CC=C1)NC(=O)C=C)NC2=NC=C3C=C(C=CC3=N2)C4=C(C(=CC(=C4Cl)OC)OC)Cl
    InChIKey
    TXEBNKKOLVBTFK-UHFFFAOYSA-N
    InChI
    1S/C26H22Cl2N4O3/c1-5-21(33)30-18-8-6-7-14(2)25(18)32-26-29-13-16-11-15(9-10-17(16)31-26)22-23(27)19(34-3)12-20(35-4)24(22)28/h5-13H,1H2,2-4H3,(H,30,3show more
    Synonyms
    B0084-470871 | BLU 9931 [WHO-DD] | N-(2-((6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino)-3-methylphenyl)a...
  3. Ki8751
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    Ki8751
    CAS: 228559-41-9 Formula: C24H18F3N3O4 Molecular Weight: 469.41
    ≥98%
    In Stock Item #: K125876
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    IUPAC Name
    1-(2,4-difluorophenyl)-3-[4-(6,7-dimethoxyquinolin-4-yl)oxy-2-fluorophenyl]urea
    SMILES
    COC1=CC2=C(C=CN=C2C=C1OC)OC3=CC(=C(C=C3)NC(=O)NC4=C(C=C(C=C4)F)F)F
    InChIKey
    LFKQSJNCVRGFCC-UHFFFAOYSA-N
    InChI
    1S/C24H18F3N3O4/c1-32-22-11-15-20(12-23(22)33-2)28-8-7-21(15)34-14-4-6-19(17(27)10-14)30-24(31)29-18-5-3-13(25)9-16(18)26/h3-12H,1-2H3,(H2,29,30,31)
    Synonyms
    1-(2,4-difluorophenyl)-3-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-fluorophenyl]urea | HMS1787L13 | SB19355 | BRD-K47150...
  4. LY2874455, Inhibitor of fibroblast growth factor receptor 1;Inhibitor of fibroblast growth factor receptor 2;Inhibitor of fibroblast growth factor receptor 3;Inhibitor of fibroblast growth factor receptor 4;Inhibitor of kinase insert domain receptor
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    LY2874455, Inhibitor of fibroblast growth factor receptor 1;Inhibitor of fibroblast growth factor receptor 2;Inhibitor of fibroblast growth factor receptor 3;Inhibitor of fibroblast growth factor receptor 4;Inhibitor of kinase insert domain receptor
    CAS: 1254473-64-7 Formula: C21H19Cl2N5O2 Molecular Weight: 444.31
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
    In Stock Item #: L126507
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    IUPAC Name
    2-[4-[(E)-2-[5-[(1R)-1-(3,5-dichloropyridin-4-yl)ethoxy]-1H-indazol-3-yl]ethenyl]pyrazol-1-yl]ethanol
    SMILES
    CC(C1=C(C=NC=C1Cl)Cl)OC2=CC3=C(C=C2)NN=C3C=CC4=CN(N=C4)CCO
    InChIKey
    GKJCVYLDJWTWQU-CXLRFSCWSA-N
    InChI
    1S/C21H19Cl2N5O2/c1-13(21-17(22)10-24-11-18(21)23)30-15-3-5-20-16(8-15)19(26-27-20)4-2-14-9-25-28(12-14)6-7-29/h2-5,8-13,29H,6-7H2,1H3,(H,26,27)/b4-2+show more
    Synonyms
    7-Chloro-1,3-dihydro-5-(o-chlorophenyl)-3-hydroxy-1-methyl-2H-1,4-benzodiazepin-2-one | C18374 | (R,E)-2-(4-(2-(5-(1-...
  5. Lenvatinib (E7080), Inhibitor of fms related receptor tyrosine kinase 4;Inhibitor of kinase insert domain receptor
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    Lenvatinib (E7080), Inhibitor of fms related receptor tyrosine kinase 4;Inhibitor of kinase insert domain receptor
    CAS: 417716-92-8 EC Number: 970-217-1 Formula: C21H19ClN4O4 Molecular Weight: 426.85
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
    In Stock Item #: L125518
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    IUPAC Name
    4-[3-chloro-4-(cyclopropylcarbamoylamino)phenoxy]-7-methoxyquinoline-6-carboxamide
    SMILES
    COC1=CC2=NC=CC(=C2C=C1C(=O)N)OC3=CC(=C(C=C3)NC(=O)NC4CC4)Cl
    InChIKey
    WOSKHXYHFSIKNG-UHFFFAOYSA-N
    InChI
    1S/C21H19ClN4O4/c1-29-19-10-17-13(9-14(19)20(23)27)18(6-7-24-17)30-12-4-5-16(15(22)8-12)26-21(28)25-11-2-3-11/h4-11H,2-3H2,1H3,(H2,23,27)(H2,25,26,28)
    Synonyms
    LENVATINIB [MI] | UNII-EE083865G2 | AS-16203 | LEV | NSC800781 | NSC-800781 | DB09078 | AKOS021983298 | LENVATINIB [I...
  6. AZD4547, Inhibitor of fibroblast growth factor receptor 1;Inhibitor of fibroblast growth factor receptor 2;Inhibitor of fibroblast growth factor receptor 3;Inhibitor of fibroblast growth factor receptor 4;Inhibitor of Insulin-like growth factor I receptor;Inhibito
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    AZD4547, Inhibitor of fibroblast growth factor receptor 1;Inhibitor of fibroblast growth factor receptor 2;Inhibitor of fibroblast growth factor receptor 3;Inhibitor of fibroblast growth factor receptor 4;Inhibitor of Insulin-like growth factor I receptor;Inhibito
    CAS: 1035270-39-3 EC Number: 681-057-4 Formula: C26H33N5O3 Molecular Weight: 463.57
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
    In Stock Item #: A127209
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    IUPAC Name
    N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-4-[(3S,5R)-3,5-dimethylpiperazin-1-yl]benzamide
    SMILES
    CC1CN(CC(N1)C)C2=CC=C(C=C2)C(=O)NC3=NNC(=C3)CCC4=CC(=CC(=C4)OC)OC
    InChIKey
    VRQMAABPASPXMW-HDICACEKSA-N
    InChI
    1S/C26H33N5O3/c1-17-15-31(16-18(2)27-17)22-9-6-20(7-10-22)26(32)28-25-13-21(29-30-25)8-5-19-11-23(33-3)14-24(12-19)34-4/h6-7,9-14,17-18,27H,5,8,15-16Hshow more
    Synonyms
    J-000994 | N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-4-[(3R,5S)-3,5-dimethylpiperazin-1-yl]benzamide | NSC...
  7. Futibatinib, Fibroblast growth factor receptor inhibitor
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    Futibatinib, Fibroblast growth factor receptor inhibitor
    CAS: 1448169-71-8 Formula: C22H22N6O3 Molecular Weight: 418.45
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    In Stock Item #: T302895
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    IUPAC Name
    1-[(3S)-3-[4-amino-3-[2-(3,5-dimethoxyphenyl)ethynyl]pyrazolo[3,4-d]pyrimidin-1-yl]pyrrolidin-1-yl]prop-2-en-1-one
    SMILES
    COC1=CC(=CC(=C1)C#CC2=NN(C3=NC=NC(=C23)N)C4CCN(C4)C(=O)C=C)OC
    InChIKey
    KEIPNCCJPRMIAX-HNNXBMFYSA-N
    InChI
    1S/C22H22N6O3/c1-4-19(29)27-8-7-15(12-27)28-22-20(21(23)24-13-25-22)18(26-28)6-5-14-9-16(30-2)11-17(10-14)31-3/h4,9-11,13,15H,1,7-8,12H2,2-3H3,(H2,23,show more
    Synonyms
    GTPL9786 | DB15149 | FUTIBATINIB [INN] | UNII-4B93MGE4AL | D11725 | 1-((3S)-3-(4-Amino-3-((3,5-dimethoxyphenyl)ethyny...
  8. Derazantinib(ARQ-087), Fibroblast growth factor receptor inhibitor
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    Derazantinib(ARQ-087), Fibroblast growth factor receptor inhibitor
    CAS: 1234356-69-4 Formula: C29H29FN4O Molecular Weight: 468.57
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
    In Stock Item #: D302670
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    IUPAC Name
    (6R)-6-(2-fluorophenyl)-N-[3-[2-(2-methoxyethylamino)ethyl]phenyl]-5,6-dihydrobenzo[h]quinazolin-2-amine
    SMILES
    COCCNCCC1=CC(=CC=C1)NC2=NC=C3CC(C4=CC=CC=C4C3=N2)C5=CC=CC=C5F
    InChIKey
    KPJDVVCDVBFRMU-AREMUKBSSA-N
    InChI
    1S/C29H29FN4O/c1-35-16-15-31-14-13-20-7-6-8-22(17-20)33-29-32-19-21-18-26(24-10-4-5-12-27(24)30)23-9-2-3-11-25(23)28(21)34-29/h2-12,17,19,26,31H,13-16show more
    Synonyms
    Benzo(H)quinazolin-2-amine, 6-(2-fluorophenyl)-5,6-dihydro-N-(3-(2-((2-methoxyethyl)amino)ethyl)phenyl)-, (6R)- | DB1...
  9. Pemigatinib, Fibroblast growth factor receptor 1 inhibitor
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    Pemigatinib, Fibroblast growth factor receptor 1 inhibitor
    CAS: 1513857-77-6 PubChem CID: 86705695 Formula: C24H27F2N5O4 Molecular Weight: 487.50
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    In Stock Item #: P302963
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    Technical Identifiers
    IUPAC Name
    11-(2,6-difluoro-3,5-dimethoxyphenyl)-13-ethyl-4-(morpholin-4-ylmethyl)-5,7,11,13-tetrazatricyclo[7.4.0.02,6]trideca-1,3,6,8-tetraen-12-one
    SMILES
    CCN1C2=C3C=C(NC3=NC=C2CN(C1=O)C4=C(C(=CC(=C4F)OC)OC)F)CN5CCOCC5
    InChIKey
    HCDMJFOHIXMBOV-UHFFFAOYSA-N
    InChI
    1S/C24H27F2N5O4/c1-4-30-21-14(11-27-23-16(21)9-15(28-23)13-29-5-7-35-8-6-29)12-31(24(30)32)22-19(25)17(33-2)10-18(34-3)20(22)26/h9-11H,4-8,12-13H2,1-3show more
    Synonyms
    3-(2,6-Difluoro-3,5-dimethoxyphenyl)-1-ethyl-1,3,4,7-tetrahydro-8-(4-morpholinylmethyl)-2H-pyrrolo[3',2':5,6]pyrido[4...
  10. BGJ398 (NVP-BGJ398), Fibroblast growth factor receptor inhibitor
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    BGJ398 (NVP-BGJ398), Fibroblast growth factor receptor inhibitor
    CAS: 872511-34-7 Formula: C26H31Cl2N7O3 Molecular Weight: 560.48
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    In Stock Item #: N127052
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    IUPAC Name
    3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-[6-[4-(4-ethylpiperazin-1-yl)anilino]pyrimidin-4-yl]-1-methylurea
    SMILES
    CCN1CCN(CC1)C2=CC=C(C=C2)NC3=CC(=NC=N3)N(C)C(=O)NC4=C(C(=CC(=C4Cl)OC)OC)Cl
    InChIKey
    QADPYRIHXKWUSV-UHFFFAOYSA-N
    InChI
    1S/C26H31Cl2N7O3/c1-5-34-10-12-35(13-11-34)18-8-6-17(7-9-18)31-21-15-22(30-16-29-21)33(2)26(36)32-25-23(27)19(37-3)14-20(38-4)24(25)28/h6-9,14-16H,5,1show more
    Synonyms
    BGJ398 (NVP-BGJ398) | 872511-34-7 (free base) | AKOS000295891 | WHO 10032 | 3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-[6...
  11. FIIN 1 hydrochloride
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    FIIN 1 hydrochloride
    CAS: 1256152-35-8 Formula: C₃₂H₃₉Cl₂N₇O₄ Molecular Weight: 693.06
    ≥96%(HPLC)
    Out of Stock Item #: F287174
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    Technical Identifiers
    IUPAC Name
    N-[3-[[3-(2,6-dichloro-3,5-dimethoxyphenyl)-7-[4-(diethylamino)butylamino]-2-oxo-4H-pyrimido[4,5-d]pyrimidin-1-yl]methyl]phenyl]prop-2-enamide
    SMILES
    CCN(CC)CCCCNC1=NC=C2CN(C(=O)N(C2=N1)CC3=CC(=CC=C3)NC(=O)C=C)C4=C(C(=CC(=C4Cl)OC)OC)Cl
    InChIKey
    DNVFTXQYIYFQBW-UHFFFAOYSA-N
    InChI
    1S/C32H39Cl2N7O4/c1-6-26(42)37-23-13-11-12-21(16-23)19-41-30-22(18-36-31(38-30)35-14-9-10-15-39(7-2)8-3)20-40(32(41)43)29-27(33)24(44-4)17-25(45-5)28(show more
    Synonyms
    N-(3-((3-(2,6-dichloro-3,5-dimethoxyphenyl)-7-(4-(diethylamino)butylamino)-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-...
  12. ASP5878, Inhibitor of fibroblast growth factor receptor 3
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    ASP5878, Inhibitor of fibroblast growth factor receptor 3
    CAS: 1453208-66-6 Formula: C18H19F2N5O4 Molecular Weight: 407.37
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    In Stock Item #: A421669
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    Technical Identifiers
    IUPAC Name
    2-[4-[[5-[(2,6-difluoro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl]amino]pyrazol-1-yl]ethanol
    SMILES
    COC1=CC(=C(C(=C1F)COC2=CN=C(N=C2)NC3=CN(N=C3)CCO)F)OC
    InChIKey
    VDZZYOJYLLNBTD-UHFFFAOYSA-N
    InChI
    1S/C18H19F2N5O4/c1-27-14-5-15(28-2)17(20)13(16(14)19)10-29-12-7-21-18(22-8-12)24-11-6-23-25(9-11)3-4-26/h5-9,26H,3-4,10H2,1-2H3,(H,21,22,24)
    Synonyms
    MS-26988 | 2-(4-((5-((2,6-difluoro-3,5-dimethoxybenzyl)oxy)pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)ethan-1-ol | BA16683...
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