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Receptor-type tyrosine-protein kinase flt3 (FLT3)

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  1. NVP-ADW742
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    NVP-ADW742
    CAS: 475488-23-4 Formula: C28H31N5O Molecular Weight: 453.58
    ≥99%
    In Stock Item #: N126810
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    Technical Identifiers
    IUPAC Name
    5-(3-phenylmethoxyphenyl)-7-[3-(pyrrolidin-1-ylmethyl)cyclobutyl]pyrrolo[2,3-d]pyrimidin-4-amine
    SMILES
    C1CCN(C1)CC2CC(C2)N3C=C(C4=C(N=CN=C43)N)C5=CC(=CC=C5)OCC6=CC=CC=C6
    InChIKey
    LSFLAQVDISHMNB-UHFFFAOYSA-N
    InChI
    1S/C28H31N5O/c29-27-26-25(22-9-6-10-24(15-22)34-18-20-7-2-1-3-8-20)17-33(28(26)31-19-30-27)23-13-21(14-23)16-32-11-4-5-12-32/h1-3,6-10,15,17,19,21,23Hshow more
    Synonyms
    5-(3-Benzyloxyphenyl)-7-[trans-3-[(pyrrolidin-1-yl)methyl]cyclobutyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine | AS-56233 |...
  2. Lestaurtinib, Tyrosine-protein kinase receptor RET inhibitor
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    Lestaurtinib, Tyrosine-protein kinase receptor RET inhibitor
    CAS: 111358-88-4 Formula: C26H21N3O4 Molecular Weight: 439.46
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    In Stock Item #: L275009
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    IUPAC Name
    (15S,16S,18R)-16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,14,19-triazaoctacyclo[12.11.2.115,18.02,6.07,27.08,13.019,26.020,25]octacosa-1,6,8,10,1show more
    SMILES
    CC12C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(CO)O
    InChIKey
    UIARLYUEJFELEN-LROUJFHJSA-N
    InChI
    1S/C26H21N3O4/c1-25-26(32,12-30)10-18(33-25)28-16-8-4-2-6-13(16)20-21-15(11-27-24(21)31)19-14-7-3-5-9-17(14)29(25)23(19)22(20)28/h2-9,18,30,32H,10-12Hshow more
    Synonyms
    SPM-924 | (5S,6S,8R)-6-hydroxy-6-(hydroxymethyl)-5-methyl-7,8,14,15-tetrahydro-5H-16-oxa-4b,8a,14-triaza-5,8-methanod...
  3. Galangin
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    Galangin
    CAS: 548-83-4 EC Number: 208-960-4 Formula: C15H10O5 Molecular Weight: 270.24
    Analytical standard ? Analytical standard — certified-purity material for quantitative calibration. Use to prepare calibration standards and validate analytical methods. Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
    In Stock Item #: G100562
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    IUPAC Name
    3,5,7-trihydroxy-2-phenylchromen-4-one
    SMILES
    C1=CC=C(C=C1)C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O
    InChIKey
    VCCRNZQBSJXYJD-UHFFFAOYSA-N
    InChI
    1S/C15H10O5/c16-9-6-10(17)12-11(7-9)20-15(14(19)13(12)18)8-4-2-1-3-5-8/h1-7,16-17,19H
    Synonyms
    Norizalpinin | 3,5,7-Trihydroxyflavone | 3,5,7-Trihydroxy-2-phenyl-4H-chromen-4-one
  4. UNC2371(MRX-2843)
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    UNC2371(MRX-2843)
    CAS: 1429882-07-4 PubChem CID: 89495685 Formula: C29H40N6O Molecular Weight: 488.67
    ≥97%
    Out of Stock Item #: U174179
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    IUPAC Name
    4-[2-(2-cyclopropylethylamino)-5-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-ol
    SMILES
    CN1CCN(CC1)CC2=CC=C(C=C2)C3=CN(C4=NC(=NC=C34)NCCC5CC5)C6CCC(CC6)O
    InChIKey
    LBEJYFVJIPQSNX-UHFFFAOYSA-N
    InChI
    1S/C29H40N6O/c1-33-14-16-34(17-15-33)19-22-4-6-23(7-5-22)27-20-35(24-8-10-25(36)11-9-24)28-26(27)18-31-29(32-28)30-13-12-21-2-3-21/h4-7,18,20-21,24-25show more
    Synonyms
    s6839 | Cyclohexanol, 4-(2-((2-cyclopropylethyl)amino)-5-(4-((4-methyl-1-piperazinyl)methyl)phenyl)-7H-pyrrolo(2,3-d)...
  5. MK-2461, Hepatocyte growth factor receptor inhibitor
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    MK-2461, Hepatocyte growth factor receptor inhibitor
    CAS: 917879-39-1 Formula: C24H25N5O5S Molecular Weight: 495.55
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    In Stock Item #: M129777
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    IUPAC Name
    14-[[[(2R)-1,4-dioxan-2-yl]methyl-methylsulfamoyl]amino]-5-(1-methylpyrazol-4-yl)-2-oxo-7-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,9,12,14-heptshow more
    SMILES
    CN1C=C(C=N1)C2=CC3=C(C=CC4=C(C3=O)C=C(C=C4)NS(=O)(=O)N(C)CC5COCCO5)N=C2
    InChIKey
    JGEBLDKNWBUGRZ-HXUWFJFHSA-N
    InChI
    1S/C24H25N5O5S/c1-28-13-18(12-26-28)17-9-22-23(25-11-17)6-4-16-3-5-19(10-21(16)24(22)30)27-35(31,32)29(2)14-20-15-33-7-8-34-20/h3-6,9-13,20,27H,7-8,14show more
    Synonyms
    SCHEMBL93526 | NCGC00346695-05 | CCG-264723 | FT-0631528 | NSC800795 | NSC-800795 | EX-A1566 | SY003220 | UNII-4200RD...
  6. R406 (free base), Tyrosine-protein kinase SYK inhibitor
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    R406 (free base), Tyrosine-protein kinase SYK inhibitor
    CAS: 841290-80-0 EC Number: 617-533-5 PubChem CID: 11213558 Formula: C22H23FN6O5 Molecular Weight: 470.45
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
    In Stock Item #: R129910
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    IUPAC Name
    6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one
    SMILES
    CC1(C(=O)NC2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)C
    InChIKey
    NHHQJBCNYHBUSI-UHFFFAOYSA-N
    InChI
    1S/C22H23FN6O5/c1-22(2)20(30)28-19-13(34-22)6-7-16(27-19)26-18-12(23)10-24-21(29-18)25-11-8-14(31-3)17(33-5)15(9-11)32-4/h6-10H,1-5H3,(H3,24,25,26,27,show more
    Synonyms
    HY-11108 | 2H-PYRIDO[3,2-B]-1,4-OXAZIN-3(4H)-ONE,6-[[5-FLUORO-2-[(3,4,5-TRIMETHOXPHENYL)AMINO]-4-PYRIMIDINYL]AMINO]-2...
  7. Gilteritinib, Tyrosine-protein kinase receptor UFO inhibitor
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    Gilteritinib, Tyrosine-protein kinase receptor UFO inhibitor
    CAS: 1254053-43-4 EC Number: 107-777-6 Formula: C29H44N8O3 Molecular Weight: 552.7115
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥97%
    In Stock Item #: G172979
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    IUPAC Name
    6-ethyl-3-[3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]anilino]-5-(oxan-4-ylamino)pyrazine-2-carboxamide
    SMILES
    CCC1=C(N=C(C(=N1)C(=O)N)NC2=CC(=C(C=C2)N3CCC(CC3)N4CCN(CC4)C)OC)NC5CCOCC5
    InChIKey
    GYQYAJJFPNQOOW-UHFFFAOYSA-N
    InChI
    1S/C29H44N8O3/c1-4-23-28(31-20-9-17-40-18-10-20)34-29(26(33-23)27(30)38)32-21-5-6-24(25(19-21)39-3)37-11-7-22(8-12-37)36-15-13-35(2)14-16-36/h5-6,19-2show more
    Synonyms
    GILTERITINIB [WHO-DD] | Gilteritinib HCl | NCGC00481652-01 | AS-35199 | GILTERITINIB [MI] | 1,4-Oxadiazole, 2-(o-hydr...
  8. SAR131675
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    SAR131675
    CAS: 1433953-83-3 PubChem CID: 71295845 Formula: C18H22N4O4 Molecular Weight: 358.39
    ≥98%
    In Stock Item #: S126571
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    Technical Identifiers
    IUPAC Name
    2-amino-1-ethyl-7-[(3R)-3-hydroxy-4-methoxy-3-methylbut-1-ynyl]-N-methyl-4-oxo-1,8-naphthyridine-3-carboxamide
    SMILES
    CCN1C(=C(C(=O)C2=C1N=C(C=C2)C#CC(C)(COC)O)C(=O)NC)N
    InChIKey
    PFMPOBVAYMTUOX-GOSISDBHSA-N
    InChI
    1S/C18H22N4O4/c1-5-22-15(19)13(17(24)20-3)14(23)12-7-6-11(21-16(12)22)8-9-18(2,25)10-26-4/h6-7,25H,5,10,19H2,1-4H3,(H,20,24)/t18-/m1/s1
    Synonyms
    (R)-2-amino-1-ethyl-7-(3-hydroxy-4-methoxy-3-methylbut-1-ynyl)-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxa...
  9. SGI-1776 free base, Inhibitor of fms related receptor tyrosine kinase 3;Inhibitor of histone H3 associated protein kinase;Inhibitor of Pim-1 proto-oncogene; serine/threonine kinase;Inhibitor of Pim-2 proto-oncogene; serine/threonine kinase;Inhibitor of Pim-3 proto-oncogene;
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    SGI-1776 free base, Inhibitor of fms related receptor tyrosine kinase 3;Inhibitor of histone H3 associated protein kinase;Inhibitor of Pim-1 proto-oncogene; serine/threonine kinase;Inhibitor of Pim-2 proto-oncogene; serine/threonine kinase;Inhibitor of Pim-3 proto-oncogene;
    CAS: 1025065-69-3 PubChem CID: 24795070 Formula: C20H22F3N5O Molecular Weight: 405.42
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    In Stock Item #: S126376
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    IUPAC Name
    N-[(1-methylpiperidin-4-yl)methyl]-3-[3-(trifluoromethoxy)phenyl]imidazo[1,2-b]pyridazin-6-amine
    SMILES
    CN1CCC(CC1)CNC2=NN3C(=NC=C3C4=CC(=CC=C4)OC(F)(F)F)C=C2
    InChIKey
    MHXGEROHKGDZGO-UHFFFAOYSA-N
    InChI
    1S/C20H22F3N5O/c1-27-9-7-14(8-10-27)12-24-18-5-6-19-25-13-17(28(19)26-18)15-3-2-4-16(11-15)29-20(21,22)23/h2-6,11,13-14H,7-10,12H2,1H3,(H,24,26)
    Synonyms
    N-[(1-methylpiperidin-4-yl)methyl]-3-[3-(trifluoromethoxy)phenyl]imidazo[2,1-f]pyridazin-6-amine | Imidazo[1,2-b]pyri...
  10. SP600125, Inhibitor of mitogen-activated protein kinase 10;Inhibitor of mitogen-activated protein kinase 8;Inhibitor of mitogen-activated protein kinase 9
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    SP600125, Inhibitor of mitogen-activated protein kinase 10;Inhibitor of mitogen-activated protein kinase 8;Inhibitor of mitogen-activated protein kinase 9
    CAS: 129-56-6 EC Number: 204-955-6 PubChem CID: 8515 Formula: C14H8N2O Molecular Weight: 220.233
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    In Stock Item #: S125267
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    IUPAC Name
    14,15-diazatetracyclo[7.6.1.02,7.013,16]hexadeca-1(15),2,4,6,9(16),10,12-heptaen-8-one
    SMILES
    C1=CC=C2C(=C1)C3=NNC4=CC=CC(=C43)C2=O
    InChIKey
    ACPOUJIDANTYHO-UHFFFAOYSA-N
    InChI
    1S/C14H8N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7H,(H,15,16)
    Synonyms
    HMS1362F07 | KBioGR_000406 | Anthra[1-9-cd]pyrazol-6(2H)-one | SDCCGSBI-0050458.P003 | WLN: T C66651A P IV OMNJ | Pyr...
  11. Galangin, Antagonist of A 1 receptor;Antagonist of A 2A receptor;Antagonist of A 3 receptor;Channel blocker of TRPC5
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    Galangin, Antagonist of A 1 receptor;Antagonist of A 2A receptor;Antagonist of A 3 receptor;Channel blocker of TRPC5
    CAS: 548-83-4 EC Number: 208-960-4 Formula: C15H10O5 Molecular Weight: 270.24
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    In Stock Item #: G100561
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    Technical Identifiers
    IUPAC Name
    3,5,7-trihydroxy-2-phenylchromen-4-one
    SMILES
    C1=CC=C(C=C1)C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O
    InChIKey
    VCCRNZQBSJXYJD-UHFFFAOYSA-N
    InChI
    1S/C15H10O5/c16-9-6-10(17)12-11(7-9)20-15(14(19)13(12)18)8-4-2-1-3-5-8/h1-7,16-17,19H
    Synonyms
    EX-A4261 | GALANGIN [MI] | 142FWE6ECS | 3,5,7-trihydroxy-2-phenyl-1-benzopyran-4-one | 3,5,7-trihydroxy-2-phenyl-4H-b...
  12. PHA-665752, Inhibitor of MET proto-oncogene; receptor tyrosine kinase
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    PHA-665752, Inhibitor of MET proto-oncogene; receptor tyrosine kinase
    CAS: 477575-56-7 Formula: C32H34Cl2N4O4S Molecular Weight: 641.61
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    In Stock Item #: P125191
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    Technical Identifiers
    IUPAC Name
    (3Z)-5-[(2,6-dichlorophenyl)methylsulfonyl]-3-[[3,5-dimethyl-4-[(2R)-2-(pyrrolidin-1-ylmethyl)pyrrolidine-1-carbonyl]-1H-pyrrol-2-yl]methylidene]-1H-ishow more
    SMILES
    CC1=C(NC(=C1C(=O)N2CCCC2CN3CCCC3)C)C=C4C5=C(C=CC(=C5)S(=O)(=O)CC6=C(C=CC=C6Cl)Cl)NC4=O
    InChIKey
    OYONTEXKYJZFHA-SSHUPFPWSA-N
    InChI
    1S/C32H34Cl2N4O4S/c1-19-29(35-20(2)30(19)32(40)38-14-6-7-21(38)17-37-12-3-4-13-37)16-24-23-15-22(10-11-28(23)36-31(24)39)43(41,42)18-25-26(33)8-5-9-27show more
    Synonyms
    PHA-665752 hydrate | (3Z)-5-{[(2,6-dichlorophenyl)methane]sulfonyl}-3-[(3,5-dimethyl-4-{[(2R)-2-(pyrrolidin-1-ylmethy...
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