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Tyrosine-protein kinase mer (MERTK)

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  1. Foretinib (GSK1363089), Vascular endothelial growth factor receptor inhibitor
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    Foretinib (GSK1363089), Vascular endothelial growth factor receptor inhibitor
    CAS: 849217-64-7 EC Number: 629-893-0 Formula: C34H34F2N4O6 Molecular Weight: 632.65
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    In Stock Item #: F127011
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    IUPAC Name
    1-N'-[3-fluoro-4-[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxyphenyl]-1-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
    SMILES
    COC1=CC2=C(C=CN=C2C=C1OCCCN3CCOCC3)OC4=C(C=C(C=C4)NC(=O)C5(CC5)C(=O)NC6=CC=C(C=C6)F)F
    InChIKey
    CXQHYVUVSFXTMY-UHFFFAOYSA-N
    InChI
    1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3show more
    Synonyms
    81FH7VK1C4 | Foretinib [USAN:INN] | N-(3-FLUORO-4-((6-METHOXY-7-(3-(MORPHOLIN-4-YL)PROPOXY)QUINOLIN-4-YL)OXY) PHENYL)...
  2. UNC2371(MRX-2843)
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    UNC2371(MRX-2843)
    CAS: 1429882-07-4 PubChem CID: 89495685 Formula: C29H40N6O Molecular Weight: 488.67
    ≥97%
    Out of Stock Item #: U174179
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    IUPAC Name
    4-[2-(2-cyclopropylethylamino)-5-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-ol
    SMILES
    CN1CCN(CC1)CC2=CC=C(C=C2)C3=CN(C4=NC(=NC=C34)NCCC5CC5)C6CCC(CC6)O
    InChIKey
    LBEJYFVJIPQSNX-UHFFFAOYSA-N
    InChI
    1S/C29H40N6O/c1-33-14-16-34(17-15-33)19-22-4-6-23(7-5-22)27-20-35(24-8-10-25(36)11-9-24)28-26(27)18-31-29(32-28)30-13-12-21-2-3-21/h4-7,18,20-21,24-25show more
    Synonyms
    s6839 | Cyclohexanol, 4-(2-((2-cyclopropylethyl)amino)-5-(4-((4-methyl-1-piperazinyl)methyl)phenyl)-7H-pyrrolo(2,3-d)...
  3. MK-2461, Hepatocyte growth factor receptor inhibitor
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    MK-2461, Hepatocyte growth factor receptor inhibitor
    CAS: 917879-39-1 Formula: C24H25N5O5S Molecular Weight: 495.55
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    In Stock Item #: M129777
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    IUPAC Name
    14-[[[(2R)-1,4-dioxan-2-yl]methyl-methylsulfamoyl]amino]-5-(1-methylpyrazol-4-yl)-2-oxo-7-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,9,12,14-heptshow more
    SMILES
    CN1C=C(C=N1)C2=CC3=C(C=CC4=C(C3=O)C=C(C=C4)NS(=O)(=O)N(C)CC5COCCO5)N=C2
    InChIKey
    JGEBLDKNWBUGRZ-HXUWFJFHSA-N
    InChI
    1S/C24H25N5O5S/c1-28-13-18(12-26-28)17-9-22-23(25-11-17)6-4-16-3-5-19(10-21(16)24(22)30)27-35(31,32)29(2)14-20-15-33-7-8-34-20/h3-6,9-13,20,27H,7-8,14show more
    Synonyms
    SCHEMBL93526 | NCGC00346695-05 | CCG-264723 | FT-0631528 | NSC800795 | NSC-800795 | EX-A1566 | SY003220 | UNII-4200RD...
  4. LY2801653, Hepatocyte growth factor receptor inhibitor
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    LY2801653, Hepatocyte growth factor receptor inhibitor
    CAS: 1206799-15-6 EC Number: 806-589-8 Formula: C30H22F2N6O3 Molecular Weight: 552.53
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    In Stock Item #: L127298
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    IUPAC Name
    N-[3-fluoro-4-[1-methyl-6-(1H-pyrazol-4-yl)indazol-5-yl]oxyphenyl]-1-(4-fluorophenyl)-6-methyl-2-oxopyridine-3-carboxamide
    SMILES
    CC1=CC=C(C(=O)N1C2=CC=C(C=C2)F)C(=O)NC3=CC(=C(C=C3)OC4=C(C=C5C(=C4)C=NN5C)C6=CNN=C6)F
    InChIKey
    QHADVLVFMKEIIP-UHFFFAOYSA-N
    InChI
    1S/C30H22F2N6O3/c1-17-3-9-23(30(40)38(17)22-7-4-20(31)5-8-22)29(39)36-21-6-10-27(25(32)12-21)41-28-11-18-16-35-37(2)26(18)13-24(28)19-14-33-34-15-19/hshow more
    Synonyms
    2,2'-Dithiobis[benzothiazole] | SCHEMBL2716 | s7014 | NSC800788 | NSC-800788 | CCG-270011 | LY 2801653 | BDBM50172078...
  5. Sulfatinib, Vascular endothelial growth factor receptor inhibitor
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    Sulfatinib, Vascular endothelial growth factor receptor inhibitor
    CAS: 1308672-74-3 Formula: C24H28N6O3S Molecular Weight: 480.58
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    In Stock Item #: N190510
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    IUPAC Name
    N-[2-(dimethylamino)ethyl]-1-[3-[[4-[(2-methyl-1H-indol-5-yl)oxy]pyrimidin-2-yl]amino]phenyl]methanesulfonamide
    SMILES
    CC1=CC2=C(N1)C=CC(=C2)OC3=NC(=NC=C3)NC4=CC=CC(=C4)CS(=O)(=O)NCCN(C)C
    InChIKey
    TTZSNFLLYPYKIL-UHFFFAOYSA-N
    InChI
    1S/C24H28N6O3S/c1-17-13-19-15-21(7-8-22(19)27-17)33-23-9-10-25-24(29-23)28-20-6-4-5-18(14-20)16-34(31,32)26-11-12-30(2)3/h4-10,13-15,26-27H,11-12,16H2show more
    Synonyms
    D71057 | Surufatinib [INN] | HY-12297 | C.I. 16255 | AS-74954 | B2K5L1L8S9 | GTPL9769 | Benzenemethanesulfonamide, N-...
  6. BMS-777607, Inhibitor of AXL receptor tyrosine kinase;Inhibitor of macrophage stimulating 1 receptor;Inhibitor of MER proto-oncogene; tyrosine kinase;Inhibitor of MET proto-oncogene; receptor tyrosine kinase;Inhibitor of TYRO3 protein tyrosine kinase
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    BMS-777607, Inhibitor of AXL receptor tyrosine kinase;Inhibitor of macrophage stimulating 1 receptor;Inhibitor of MER proto-oncogene; tyrosine kinase;Inhibitor of MET proto-oncogene; receptor tyrosine kinase;Inhibitor of TYRO3 protein tyrosine kinase
    CAS: 1025720-94-8 EC Number: 110-725-5 Formula: C25H19ClF2N4O4 Molecular Weight: 512.89
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    In Stock Item #: B129782
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    IUPAC Name
    N-[4-(2-amino-3-chloropyridin-4-yl)oxy-3-fluorophenyl]-4-ethoxy-1-(4-fluorophenyl)-2-oxopyridine-3-carboxamide
    SMILES
    CCOC1=C(C(=O)N(C=C1)C2=CC=C(C=C2)F)C(=O)NC3=CC(=C(C=C3)OC4=C(C(=NC=C4)N)Cl)F
    InChIKey
    VNBRGSXVFBYQNN-UHFFFAOYSA-N
    InChI
    1S/C25H19ClF2N4O4/c1-2-35-19-10-12-32(16-6-3-14(27)4-7-16)25(34)21(19)24(33)31-15-5-8-18(17(28)13-15)36-20-9-11-30-23(29)22(20)26/h3-13H,2H2,1H3,(H2,2show more
    Synonyms
    FT-0701277 | SCHEMBL2588311 | 3-Pyridinecarboxamide, N-[4-[(2-amino-3-chloro-4-pyridinyl)oxy]-3-fluorophenyl]-4-ethox...
  7. R428 (BGB324), Tyrosine-protein kinase receptor UFO inhibitor
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    R428 (BGB324), Tyrosine-protein kinase receptor UFO inhibitor
    CAS: 1037624-75-1 EC Number: 894-430-3 PubChem CID: 46215462 Formula: C30H34N8 Molecular Weight: 506.64
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    In Stock Item #: R127995
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    IUPAC Name
    1-(3,4-diazatricyclo[9.4.0.02,7]pentadeca-1(15),2,4,6,11,13-hexaen-5-yl)-3-N-[(7S)-7-pyrrolidin-1-yl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-3-yl]-1,2,4show more
    SMILES
    C1CCN(C1)C2CCC3=C(CC2)C=C(C=C3)NC4=NN(C(=N4)N)C5=NN=C6C(=C5)CCCC7=CC=CC=C76
    InChIKey
    KXMZDGSRSGHMMK-VWLOTQADSA-N
    InChI
    1S/C30H34N8/c31-29-33-30(32-24-13-10-20-11-14-25(15-12-22(20)18-24)37-16-3-4-17-37)36-38(29)27-19-23-8-5-7-21-6-1-2-9-26(21)28(23)35-34-27/h1-2,6,9-10show more
    Synonyms
    BGB324; BGB-324; BGB 324; R 428; R-428; Bemcentinib | NSC824183 | NSC-824183 | BCP21180 | R428 | R-428 | GTPL10478 | ...
  8. UNC2025
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    UNC2025
    CAS: 1429881-91-3 Formula: C28H40N6O Molecular Weight: 476.66
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥97%
    In Stock Item #: M174178
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    IUPAC Name
    4-[2-(butylamino)-5-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-ol
    SMILES
    CCCCNC1=NC=C2C(=CN(C2=N1)C3CCC(CC3)O)C4=CC=C(C=C4)CN5CCN(CC5)C
    InChIKey
    MJSHVHLADKXCML-UHFFFAOYSA-N
    InChI
    1S/C28H40N6O/c1-3-4-13-29-28-30-18-25-26(20-34(27(25)31-28)23-9-11-24(35)12-10-23)22-7-5-21(6-8-22)19-33-16-14-32(2)15-17-33/h5-8,18,20,23-24,35H,3-4,show more
    Synonyms
    mrx-6313 | UNC 2025 | UNC-2025 | trans-4-(2-(Butylamino)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-7H-pyrrolo[2,3-...
  9. AT9283, Tyrosine-protein kinase JAK3 inhibitor
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    AT9283, Tyrosine-protein kinase JAK3 inhibitor
    CAS: 896466-04-9 Formula: C19H23N7O2 Molecular Weight: 381.43
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    In Stock Item #: A409020
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    Synonyms
    1-cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)urea
  10. AT9283, Tyrosine-protein kinase JAK3 inhibitor
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    AT9283, Tyrosine-protein kinase JAK3 inhibitor
    CAS: 896466-04-9 Formula: C19H23N7O2 Molecular Weight: 381.43
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    In Stock Item #: A127488
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    IUPAC Name
    1-cyclopropyl-3-[5-[6-(morpholin-4-ylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl]urea
    SMILES
    C1CC1NC(=O)NC2=C(NN=C2)C3=NC4=C(N3)C=C(C=C4)CN5CCOCC5
    InChIKey
    LOLPPWBBNUVNQZ-UHFFFAOYSA-N
    InChI
    1S/C19H23N7O2/c27-19(21-13-2-3-13)24-16-10-20-25-17(16)18-22-14-4-1-12(9-15(14)23-18)11-26-5-7-28-8-6-26/h1,4,9-10,13H,2-3,5-8,11H2,(H,20,25)(H,22,23)show more
    Synonyms
    NSC799339 | NSC-799339 | AKOS016006006 | 1-cyclopropyl-3-[(3Z)-3-[5-(morpholin-4-ylmethyl)benzimidazol-2-ylidene]-1,2...
  11. BMS-777607, Inhibitor of AXL receptor tyrosine kinase;Inhibitor of macrophage stimulating 1 receptor;Inhibitor of MER proto-oncogene; tyrosine kinase;Inhibitor of MET proto-oncogene; receptor tyrosine kinase;Inhibitor of TYRO3 protein tyrosine kinase
    Wish List Compare
    BMS-777607, Inhibitor of AXL receptor tyrosine kinase;Inhibitor of macrophage stimulating 1 receptor;Inhibitor of MER proto-oncogene; tyrosine kinase;Inhibitor of MET proto-oncogene; receptor tyrosine kinase;Inhibitor of TYRO3 protein tyrosine kinase
    CAS: 1025720-94-8 EC Number: 110-725-5 Formula: C25H19ClF2N4O4 Molecular Weight: 512.89
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    In Stock Item #: B408833
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    Synonyms
    BMS 817378 | N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyri...
  12. Bemcentinib (R428), Tyrosine-protein kinase receptor UFO inhibitor
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    Bemcentinib (R428), Tyrosine-protein kinase receptor UFO inhibitor
    CAS: 1037624-75-1 EC Number: 894-430-3 PubChem CID: 46215462 Formula: C30H34N8 Molecular Weight: 506.64
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    In Stock Item #: B408280
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    Synonyms
    BGB324 | 1H-1,2,4-Triazole-3,5-diamine, 1-(6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3-yl)-N3-[(7S)-6,7,8,9...
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