Vascular endothelial growth factor receptor 1 (FLT1)

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  1. AEE788 (NVP-AEE788), Vascular endothelial growth factor receptor 1 inhibitor
    CAS: 497839-62-0 Formula: C27H32N6 Molecular Weight: 440.58
    In Stock Item #: A126830
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    IUPAC Name
    6-[4-[(4-ethylpiperazin-1-yl)methyl]phenyl]-N-[(1R)-1-phenylethyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
    SMILES
    CCN1CCN(CC1)CC2=CC=C(C=C2)C3=CC4=C(N3)N=CN=C4NC(C)C5=CC=CC=C5
    InChIKey
    OONFNUWBHFSNBT-HXUWFJFHSA-N
    InChI
    1S/C27H32N6/c1-3-32-13-15-33(16-14-32)18-21-9-11-23(12-10-21)25-17-24-26(28-19-29-27(24)31-25)30-20(2)22-7-5-4-6-8-22/h4-12,17,19-20H,3,13-16,18H2,1-2show more
    Synonyms
    6-[4-[(4-ethylpiperazin-1-yl)methyl]phenyl]-N-[(1R)-1-phenylethyl]-7H-pyrrolo[3,2-e]pyrimidin-4-amine | 7,9-Dimethyl-...
  2. ZM 306416, Inhibitor of epidermal growth factor receptor;Inhibitor of fms related receptor tyrosine kinase 1;Inhibitor of kinase insert domain receptor
    CAS: 690206-97-4 PubChem CID: 5329006 Formula: C16H13ClFN3O2 Molecular Weight: 333.74
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    In Stock Item #: Z129748
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    IUPAC Name
    N-(4-chloro-2-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine
    SMILES
    COC1=C(C=C2C(=C1)C(=NC=N2)NC3=C(C=C(C=C3)Cl)F)OC
    InChIKey
    YHUIUSRCUKUUQA-UHFFFAOYSA-N
    InChI
    1S/C16H13ClFN3O2/c1-22-14-6-10-13(7-15(14)23-2)19-8-20-16(10)21-12-4-3-9(17)5-11(12)18/h3-8H,1-2H3,(H,19,20,21)
    Synonyms
    s2897 | HY-13785 | KBio2_005169 | N-(4-Chloro-2-fluorophenyl)-6,7-dimethoxy-4-quinazolinamine | 1-[2-[(4-Chlorophenyl...
  3. Lapatinib, Inhibitor of epidermal growth factor receptor;Inhibitor of erb-b2 receptor tyrosine kinase 2
    CAS: 231277-92-2 EC Number: 878-720-7 Formula: C29H26ClFN4O4S Molecular Weight: 581.06
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
    In Stock Item #: L126696
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    IUPAC Name
    N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine
    SMILES
    CS(=O)(=O)CCNCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl
    InChIKey
    BCFGMOOMADDAQU-UHFFFAOYSA-N
    InChI
    1S/C29H26ClFN4O4S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19/h2-10show more
    Synonyms
    EN300-117254 | Kinome_3685 | 231277-92-2 (free base) | D08108 | GSK 572016 | GTPL5692 | Lapatinib free base | N-(3-ch...
  4. MK-2461, Hepatocyte growth factor receptor inhibitor
    CAS: 917879-39-1 Formula: C24H25N5O5S Molecular Weight: 495.55
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    In Stock Item #: M129777
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    IUPAC Name
    14-[[[(2R)-1,4-dioxan-2-yl]methyl-methylsulfamoyl]amino]-5-(1-methylpyrazol-4-yl)-2-oxo-7-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,9,12,14-heptshow more
    SMILES
    CN1C=C(C=N1)C2=CC3=C(C=CC4=C(C3=O)C=C(C=C4)NS(=O)(=O)N(C)CC5COCCO5)N=C2
    InChIKey
    JGEBLDKNWBUGRZ-HXUWFJFHSA-N
    InChI
    1S/C24H25N5O5S/c1-28-13-18(12-26-28)17-9-22-23(25-11-17)6-4-16-3-5-19(10-21(16)24(22)30)27-35(31,32)29(2)14-20-15-33-7-8-34-20/h3-6,9-13,20,27H,7-8,14show more
    Synonyms
    SCHEMBL93526 | NCGC00346695-05 | CCG-264723 | FT-0631528 | NSC800795 | NSC-800795 | EX-A1566 | SY003220 | UNII-4200RD...
  5. ALW-II-41-27
    CAS: 1186206-79-0 Formula: C32H32F3N5O2S Molecular Weight: 607.69
    In Stock Item #: A127683
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    IUPAC Name
    N-[5-[[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]carbamoyl]-2-methylphenyl]-5-thiophen-2-ylpyridine-3-carboxamide
    SMILES
    CCN1CCN(CC1)CC2=C(C=C(C=C2)NC(=O)C3=CC(=C(C=C3)C)NC(=O)C4=CN=CC(=C4)C5=CC=CS5)C(F)(F)F
    InChIKey
    HYWXBDQAYLPMIX-UHFFFAOYSA-N
    InChI
    1S/C32H32F3N5O2S/c1-3-39-10-12-40(13-11-39)20-23-8-9-26(17-27(23)32(33,34)35)37-30(41)22-7-6-21(2)28(16-22)38-31(42)25-15-24(18-36-19-25)29-5-4-14-43-show more
    Synonyms
    EX-A2618 | ALW-II-41-27 | HMS3333E20 | BCP26205 | HMS2043H01 | HY-18007 | SCHEMBL20136698 | N-[5-({4-[(4-Ethylpiperaz...
  6. VU0152100, Allosteric modulator of M 4 receptor
    CAS: 409351-28-6 EC Number: 684-470-8 PubChem CID: 864492 Formula: C18H19N3O2S Molecular Weight: 341.43
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    In Stock Item #: V275410
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    IUPAC Name
    3-amino-N-[(4-methoxyphenyl)methyl]-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide
    SMILES
    CC1=CC(=NC2=C1C(=C(S2)C(=O)NCC3=CC=C(C=C3)OC)N)C
    InChIKey
    MDNWGCQSCGNTKH-UHFFFAOYSA-N
    InChI
    1S/C18H19N3O2S/c1-10-8-11(2)21-18-14(10)15(19)16(24-18)17(22)20-9-12-4-6-13(23-3)7-5-12/h4-8H,9,19H2,1-3H3,(H,20,22)
    Synonyms
    MFCD02742972 | VU0152100-1 | 3-AMINO-4,6-DIMETHYL-THIENO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID 4-METHOXY-BENZYLAMIDE | NCG...
  7. Vatalanib succinate
    CAS: 212142-18-2 EC Number: 658-085-0 PubChem CID: 151193 Formula: C20H15ClN4•C4H6O4 Molecular Weight: 464.90
    In Stock Item #: V286725
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    IUPAC Name
    butanedioic acid;N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine
    SMILES
    C1=CC=C2C(=C1)C(=NN=C2NC3=CC=C(C=C3)Cl)CC4=CC=NC=C4.C(CC(=O)O)C(=O)O
    InChIKey
    LLDWLPRYLVPDTG-UHFFFAOYSA-N
    InChI
    1S/C20H15ClN4.C4H6O4/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24-25-20)13-14-9-11-22-12-10-14;5-3(6)1-2-4(7)8/h1-12H,13H2,(H,23,25);1-2H2,(H,5,6show more
    Synonyms
    1-(4-chloroanilino)-4-(4-pyridylmethyl)phthalazine succinate | PTK 787/ZK 222584 | 1-Phthalazinamine, N-(4-chlorophen...
  8. AR-A014418, Inhibitor of glycogen synthase kinase 3 beta
    CAS: 487021-52-3 EC Number: 637-170-6 Formula: C12H12N4O4S Molecular Weight: 308.31
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    In Stock Item #: A126821
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    IUPAC Name
    1-[(4-methoxyphenyl)methyl]-3-(5-nitro-1,3-thiazol-2-yl)urea
    SMILES
    COC1=CC=C(C=C1)CNC(=O)NC2=NC=C(S2)[N+](=O)[O-]
    InChIKey
    YAEMHJKFIIIULI-UHFFFAOYSA-N
    InChI
    1S/C12H12N4O4S/c1-20-9-4-2-8(3-5-9)6-13-11(17)15-12-14-7-10(21-12)16(18)19/h2-5,7H,6H2,1H3,(H2,13,14,15,17)
    Synonyms
    AM803946 | GSK 3b inhibitor VIII | Q27077900 | BDBM50229962 | 1276635-87-0 | AR-A014418, >=98% (HPLC), solid | GSK-3b...
  9. AST-1306, Inhibitor of epidermal growth factor receptor;Inhibitor of erb-b2 receptor tyrosine kinase 2;Inhibitor of erb-b2 receptor tyrosine kinase 4
    CAS: 897383-62-9 Formula: C24H18ClFN4O2 Molecular Weight: 448.88
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    In Stock Item #: A127889
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    IUPAC Name
    N-[4-[3-chloro-4-[(3-fluorophenyl)methoxy]anilino]quinazolin-6-yl]prop-2-enamide
    SMILES
    C=CC(=O)NC1=CC2=C(C=C1)N=CN=C2NC3=CC(=C(C=C3)OCC4=CC(=CC=C4)F)Cl
    InChIKey
    MVZGYPSXNDCANY-UHFFFAOYSA-N
    InChI
    1S/C24H18ClFN4O2/c1-2-23(31)29-17-6-8-21-19(11-17)24(28-14-27-21)30-18-7-9-22(20(25)12-18)32-13-15-4-3-5-16(26)10-15/h2-12,14H,1,13H2,(H,29,31)(H,27,2show more
    Synonyms
    ALL-3 | MANDELIC-2,3,4,5,6-D5 ACID | SB19364 | SR-01000076076-1 | XKB38362 | 4-hydroxy-3-methoxyphenylglycolic acid |...
  10. Fruquintinib, Vascular endothelial growth factor receptor inhibitor
    CAS: 1194506-26-7 EC Number: 962-485-3 Formula: C21H19N3O5 Molecular Weight: 393.39
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    In Stock Item #: F302543
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    IUPAC Name
    6-(6,7-dimethoxyquinazolin-4-yl)oxy-N,2-dimethyl-1-benzofuran-3-carboxamide
    SMILES
    CC1=C(C2=C(O1)C=C(C=C2)OC3=NC=NC4=CC(=C(C=C43)OC)OC)C(=O)NC
    InChIKey
    BALLNEJQLSTPIO-UHFFFAOYSA-N
    InChI
    1S/C21H19N3O5/c1-11-19(20(25)22-2)13-6-5-12(7-16(13)28-11)29-21-14-8-17(26-3)18(27-4)9-15(14)23-10-24-21/h5-10H,1-4H3,(H,22,25)
    Synonyms
    6-((6,7-dimethoxyquinazolin-4-yl)oxy)-N,2-dimethylbenzofuran-3-carboxamide | NSC801000 | NSC-801000 | C71641 | WHO 10...
  11. AAL 993
    CAS: 269390-77-4 Formula: C20H16N3OF3 Molecular Weight: 371.4
    In Stock Item #: A275890
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    IUPAC Name
    2-(pyridin-4-ylmethylamino)-N-[3-(trifluoromethyl)phenyl]benzamide
    SMILES
    C1=CC=C(C(=C1)C(=O)NC2=CC=CC(=C2)C(F)(F)F)NCC3=CC=NC=C3
    InChIKey
    BLAFVGLBBOPRLP-UHFFFAOYSA-N
    InChI
    1S/C20H16F3N3O/c21-20(22,23)15-4-3-5-16(12-15)26-19(27)17-6-1-2-7-18(17)25-13-14-8-10-24-11-9-14/h1-12,25H,13H2,(H,26,27)
    Synonyms
    2-[(4-Pyridinylmethyl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide
  12. Motesanib, Platelet-derived growth factor receptor inhibitor
    CAS: 453562-69-1 EC Number: 113-839-3 Formula: C22H23N5O Molecular Weight: 373.46
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    In Stock Item #: M126795
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    IUPAC Name
    N-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide
    SMILES
    CC1(CNC2=C1C=CC(=C2)NC(=O)C3=C(N=CC=C3)NCC4=CC=NC=C4)C
    InChIKey
    RAHBGWKEPAQNFF-UHFFFAOYSA-N
    InChI
    1S/C22H23N5O/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H,27,28)
    Synonyms
    N-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide | NSC800801 | NSC-800801 | H...
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