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  1. Regorafenib (BAY 73-4506), Nerve growth factor receptor Trk-A
    CAS: 755037-03-7 EC Number: 815-051-1 PubChem CID: 11167602 Formula: C21H15ClF4N4O3 Molecular Weight: 482.82
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
    In Stock Item #: R127804
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    Technical Identifiers
    IUPAC Name
    4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]-3-fluorophenoxy]-N-methylpyridine-2-carboxamide
    SMILES
    CNC(=O)C1=NC=CC(=C1)OC2=CC(=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F)F
    InChIKey
    FNHKPVJBJVTLMP-UHFFFAOYSA-N
    InChI
    1S/C21H15ClF4N4O3/c1-27-19(31)18-10-13(6-7-28-18)33-12-3-5-17(16(23)9-12)30-20(32)29-11-2-4-15(22)14(8-11)21(24,25)26/h2-10H,1H3,(H,27,31)(H2,29,30,32show more
    Synonyms
    CCG-269571 | AB00076187-01 | CHEBI:68647 | 755037-03-7 , Regorafenib | AC-25075 | MFCD16038047 | Regorafenib,BAY 73-4...
  2. BAY 826
    CAS: 1448316-08-2 Formula: C26H19F5N6OS Molecular Weight: 558.53
    Out of Stock Item #: B288179
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    IUPAC Name
    3-cyano-N-[2,4-dimethyl-5-(6-pyridin-3-ylimidazo[1,2-b]pyrazol-1-yl)phenyl]-5-(pentafluoro-λ6-sulfanyl)benzamide
    SMILES
    CC1=CC(=C(C=C1NC(=O)C2=CC(=CC(=C2)C#N)S(F)(F)(F)(F)F)N3C=CN4C3=CC(=N4)C5=CN=CC=C5)C
    InChIKey
    MPASHPJAIUOWCK-UHFFFAOYSA-N
    InChI
    1S/C26H19F5N6OS/c1-16-8-17(2)24(36-6-7-37-25(36)13-23(35-37)19-4-3-5-33-15-19)12-22(16)34-26(38)20-9-18(14-32)10-21(11-20)39(27,28,29,30)31/h3-13,15H,show more
    Synonyms
    [3-Cyano-5-[[[2,4-dimethyl-5-[6-(3-pyridinyl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl]amino]carbonyl]phenyl]pentafluoros...
  3. Tie2 kinase inhibitor, Inhibitor of TEK receptor tyrosine kinase
    CAS: 948557-43-5 PubChem CID: 23625762 Formula: C26H21N3O2S Molecular Weight: 439.53
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥97%
    In Stock Item #: T129823
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    Technical Identifiers
    IUPAC Name
    4-[4-(6-methoxynaphthalen-2-yl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine
    SMILES
    COC1=CC2=C(C=C1)C=C(C=C2)C3=C(NC(=N3)C4=CC=C(C=C4)S(=O)C)C5=CC=NC=C5
    InChIKey
    SINQIEAULQKUPD-UHFFFAOYSA-N
    InChI
    1S/C26H21N3O2S/c1-31-22-8-5-19-15-21(4-3-20(19)16-22)25-24(17-11-13-27-14-12-17)28-26(29-25)18-6-9-23(10-7-18)32(2)30/h3-16H,1-2H3,(H,28,29)
    Synonyms
    Tie2 IN 5; Tie2IN5; Tie2 inhibitor 5; Tie2-inhibitor-5; Tie2 kinase inhibitor 5 | NCGC00090707-04 | SMR004702865 | CH...
  4. BAW2881(NVP-BAW2881)
    CAS: 861875-60-7 Formula: C22H15F3N4O2 Molecular Weight: 424.38
    In Stock Item #: B413936
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    Technical Identifiers
    IUPAC Name
    6-(2-aminopyrimidin-4-yl)oxy-N-[3-(trifluoromethyl)phenyl]naphthalene-1-carboxamide
    SMILES
    C1=CC(=CC(=C1)NC(=O)C2=CC=CC3=C2C=CC(=C3)OC4=NC(=NC=C4)N)C(F)(F)F
    InChIKey
    MLLQJNIKDWEEFT-UHFFFAOYSA-N
    InChI
    1S/C22H15F3N4O2/c23-22(24,25)14-4-2-5-15(12-14)28-20(30)18-6-1-3-13-11-16(7-8-17(13)18)31-19-9-10-27-21(26)29-19/h1-12H,(H,28,30)(H2,26,27,29)
    Synonyms
    6-((2-aminopyrimidin-4-yl)oxy)-N-(3-(trifluoromethyl)phenyl)-1-naphthamide
  5. BAW2881 (NVP-BAW2881)
    CAS: 861875-60-7 Formula: C22H15F3N4O2 Molecular Weight: 424.38
    10mM in DMSO
    In Stock Item #: B426399
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    Technical Identifiers
    IUPAC Name
    6-(2-aminopyrimidin-4-yl)oxy-N-[3-(trifluoromethyl)phenyl]naphthalene-1-carboxamide
    SMILES
    C1=CC(=CC(=C1)NC(=O)C2=CC=CC3=C2C=CC(=C3)OC4=NC(=NC=C4)N)C(F)(F)F
    InChIKey
    MLLQJNIKDWEEFT-UHFFFAOYSA-N
    InChI
    1S/C22H15F3N4O2/c23-22(24,25)14-4-2-5-15(12-14)28-20(30)18-6-1-3-13-11-16(7-8-17(13)18)31-19-9-10-27-21(26)29-19/h1-12H,(H,28,30)(H2,26,27,29)
    Synonyms
    6-((2-aminopyrimidin-4-yl)oxy)-N-(3-(trifluoromethyl)phenyl)-1-naphthamide
  6. Pexmetinib (ARRY-614), Tyrosine-protein kinase TIE-2 inhibitor
    CAS: 945614-12-0 PubChem CID: 24765037 Formula: C31H33FN6O3 Molecular Weight: 556.63
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    In Stock Item #: P427042
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    Technical Identifiers
    IUPAC Name
    1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[[5-fluoro-2-[1-(2-hydroxyethyl)indazol-5-yl]oxyphenyl]methyl]urea
    SMILES
    CC1=CC=C(C=C1)N2C(=CC(=N2)C(C)(C)C)NC(=O)NCC3=C(C=CC(=C3)F)OC4=CC5=C(C=C4)N(N=C5)CCO
    InChIKey
    LNMRSSIMGCDUTP-UHFFFAOYSA-N
    InChI
    1S/C31H33FN6O3/c1-20-5-8-24(9-6-20)38-29(17-28(36-38)31(2,3)4)35-30(40)33-18-22-15-23(32)7-12-27(22)41-25-10-11-26-21(16-25)19-34-37(26)13-14-39/h5-12show more
    Synonyms
    STK934866 | 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[[5-fluoro-2-[1-(2-hydroxyethyl)indazol-5-yl]oxyphenyl]...
  7. Pexmetinib (ARRY-614), Tyrosine-protein kinase TIE-2 inhibitor
    CAS: 945614-12-0 PubChem CID: 24765037 Formula: C31H33FN6O3 Molecular Weight: 556.63
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    In Stock Item #: P413835
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    Technical Identifiers
    IUPAC Name
    1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[[5-fluoro-2-[1-(2-hydroxyethyl)indazol-5-yl]oxyphenyl]methyl]urea
    SMILES
    CC1=CC=C(C=C1)N2C(=CC(=N2)C(C)(C)C)NC(=O)NCC3=C(C=CC(=C3)F)OC4=CC5=C(C=C4)N(N=C5)CCO
    InChIKey
    LNMRSSIMGCDUTP-UHFFFAOYSA-N
    InChI
    1S/C31H33FN6O3/c1-20-5-8-24(9-6-20)38-29(17-28(36-38)31(2,3)4)35-30(40)33-18-22-15-23(32)7-12-27(22)41-25-10-11-26-21(16-25)19-34-37(26)13-14-39/h5-12show more
    Synonyms
    STK934866 | 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[[5-fluoro-2-[1-(2-hydroxyethyl)indazol-5-yl]oxyphenyl]...
  8. Regorafenib (BAY-734506) Monohydrate
    CAS: 1019206-88-2 EC Number: 851-928-5 PubChem CID: 24768591 Formula: C21H15ClF4N4O3.H2O Molecular Weight: 500.83
    10mM in DMSO
    In Stock Item #: R420361
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    Pricing & Pack Sizes
    Technical Identifiers
    IUPAC Name
    4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]-3-fluorophenoxy]-N-methylpyridine-2-carboxamide;hydrate
    SMILES
    CNC(=O)C1=NC=CC(=C1)OC2=CC(=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F)F.O
    InChIKey
    ZOPOQLDXFHBOIH-UHFFFAOYSA-N
    InChI
    1S/C21H15ClF4N4O3.H2O/c1-27-19(31)18-10-13(6-7-28-18)33-12-3-5-17(16(23)9-12)30-20(32)29-11-2-4-15(22)14(8-11)21(24,25)26;/h2-10H,1H3,(H,27,31)(H2,29,show more
    Synonyms
    D10137 | AC-25914 | MFCD17170366 | 4-{4-[({[4-chloro-3-(trifluoromethyl)-phenyl]amino}carbonyl)amino]-3-fluorophenoxy...
  9. Regorafenib (BAY-734506) Monohydrate
    CAS: 1019206-88-2 PubChem CID: 24768591 Formula: C21H15ClF4N4O3.H2O Molecular Weight: 500.83
    In Stock Item #: R413223
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    Pricing & Pack Sizes
    Technical Identifiers
    IUPAC Name
    4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]-3-fluorophenoxy]-N-methylpyridine-2-carboxamide;hydrate
    SMILES
    CNC(=O)C1=NC=CC(=C1)OC2=CC(=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F)F.O
    InChIKey
    ZOPOQLDXFHBOIH-UHFFFAOYSA-N
    InChI
    1S/C21H15ClF4N4O3.H2O/c1-27-19(31)18-10-13(6-7-28-18)33-12-3-5-17(16(23)9-12)30-20(32)29-11-2-4-15(22)14(8-11)21(24,25)26;/h2-10H,1H3,(H,27,31)(H2,29,show more
    Synonyms
    D10137 | AC-25914 | MFCD17170366 | 4-{4-[({[4-chloro-3-(trifluoromethyl)-phenyl]amino}carbonyl)amino]-3-fluorophenoxy...
  10. Nesvacumab (anti-ANGPT2), INHIBITOR of Angiopoietin-2 inhibitor
    CAS: 1296818-77-3
    Liquid Animal Free ? Animal-free — produced without animal-derived components to reduce contamination risk. Use in biomanufacturing and culture avoiding animal-origin material. Carrier Free ? Carrier-free — supplied without added carrier protein/stabilizer. Use when carriers (e.g. BSA) would interfere with conjugation or sensitive assays. Recombinant ? Recombinant — produced via recombinant expression for defined sequence and consistency. Use for reproducible, animal-free proteins of known origin. Validated ? Validated grade — performance confirmed in defined applications before release. Use when you want documented assurance the reagent works as stated. ExactAb™ ? ExactAb™ — Aladdin's antibody line emphasizing precision and validated quality. Use for reliable, specificity-validated antibody applications. Low Endotoxin ? Low-endotoxin grade — endotoxin reduced to low controlled levels. Use in sensitive biological work where high endotoxin would interfere. Azide Free ? Azide-free — without sodium azide preservative. Use in conjugations, cell work, or assays where azide is toxic or inhibitory. ≥95%(SDS-PAGE&SEC-HPLC) See COA
    In Stock Item #: Ab170536
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    Pricing & Pack Sizes
    Technical Identifiers
    Associated targets
    ANGPT2
    Short Overview
    Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
    Species reactivity(Reacts with)
    Cynomolgus monkey, Human, Mouse
    Isotype
    Human IgG1
    Host species
    Human
    Conjugation
    Unconjugated
    Synonyms
    Anti-ANGPT2 Reference Antibody (nesvacumab) | nesvacumab | AGPT 2 antibody | Agpt2 antibody | ANG 2 antibody | ANG-2 ...
  11. razuprotafib, Receptor-type tyrosine-protein phosphatase beta inhibitor
    CAS: 1008510-37-9 PubChem CID: 46700782 Formula: C26H26N4O6S3 Molecular Weight: 586.7
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.
    Out of Stock Item #: R613105
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    Technical Identifiers
    IUPAC Name
    [4-[(2S)-2-[[(2S)-2-(methoxycarbonylamino)-3-phenylpropanoyl]amino]-2-(2-thiophen-2-yl-1,3-thiazol-4-yl)ethyl]phenyl]sulfamic acid
    SMILES
    COC(=O)N[C@H](C(=O)N[C@H](c1csc(n1)c1cccs1)Cc1ccc(cc1)NS(=O)(=O)O)Cc1ccccc1
    InChIKey
    KWJDHELCGJFUHW-SFTDATJTSA-N
    InChI
    1S/C26H26N4O6S3/c1-36-26(32)29-21(15-17-6-3-2-4-7-17)24(31)27-20(22-16-38-25(28-22)23-8-5-13-37-23)14-18-9-11-19(12-10-18)30-39(33,34)35/h2-13,16,20-2show more
    Synonyms
    Compound AA34 [US10220048] | AKOS040742534 | Razuprotafib [USAN] | RAZUPROTAFIB [WHO-DD] | N-(4-{(2S)-2-{(2S)-2-[(met...
  12. Vanucizumab (anti-ANG2&VEGFA), INHIBITOR of Vascular endothelial growth factor A inhibitor
    CAS: 1448221-05-3
    Liquid Animal Free ? Animal-free — produced without animal-derived components to reduce contamination risk. Use in biomanufacturing and culture avoiding animal-origin material. Carrier Free ? Carrier-free — supplied without added carrier protein/stabilizer. Use when carriers (e.g. BSA) would interfere with conjugation or sensitive assays. Recombinant ? Recombinant — produced via recombinant expression for defined sequence and consistency. Use for reproducible, animal-free proteins of known origin. Validated ? Validated grade — performance confirmed in defined applications before release. Use when you want documented assurance the reagent works as stated. ExactAb™ ? ExactAb™ — Aladdin's antibody line emphasizing precision and validated quality. Use for reliable, specificity-validated antibody applications. Low Endotoxin ? Low-endotoxin grade — endotoxin reduced to low controlled levels. Use in sensitive biological work where high endotoxin would interfere. Azide Free ? Azide-free — without sodium azide preservative. Use in conjugations, cell work, or assays where azide is toxic or inhibitory. ≥90%(SDS-PAGE&SEC-HPLC) See COA
    In Stock Item #: Ab175696
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    Pricing & Pack Sizes
    Technical Identifiers
    Short Overview
    Purity≥90% (SDS-PAGE&SEC); Endotoxin Level≤1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
    Species reactivity(Reacts with)
    Cynomolgus monkey, Human
    Isotype
    Human IgG1
    Host species
    Human
    Conjugation
    Unconjugated
    SMILES
    [Vanucizumab]
    Synonyms
    ANG2 antibody | ANG3 antibody | Another new gene 2 protein antibody | C11orf3 antibody | chromosome 11 open reading f...
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