Lipid 5 - Moligand™, ≥98% , CAS No.2089251-33-0

CAS: 2089251-33-0 Cat. No.: L647130 Formula: C₄₄H₈₇NO₅ Molecular Weight: 710.17 PubChem CID: 126697428

GRADE & PURITY Moligand™, ≥98%

Synonyms

LIPIDV 004 | MS-31197 | nonyl 8-[(8-heptadecan-9-yloxy-8-oxooctyl)-(2-hydroxyethyl)amino]octanoate | P4TKZ45P7A | EX-A6658 | BP-26127 | Octanoic acid, 8-[(2-hydroxyethyl)[8-(nonyloxy)-8-oxooctyl]amino]-, 1-octylnonyl ester | Heptadecan-9-yl 8-((2-hydroxye

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

Application

Drug Delivery, Surface Modification, PEGylation of Protein, Peptide & Oligo

Overview

Lipid 5 is an amino lipid that affords efficient mRNA delivery in rodent and primate models. Lipid 5 shows optimal pharmacokinetics and non-toxic side effects.

In Vitro

Replacement of the linoleic tail with a primary ester-containing lipid tail (Lipid 5) provids increased expression and optimal tissue clearance. The metabolite identification studies with Lipid 5 indicated that hydrolysis of the primary ester is the first step in the metabolism of the lipid. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Clearance of Lipid 5 and MC3 from multiple mouse tissues is measured after dosing 0.05 mg/kg mRNA on days 1, 8, and 15 in CD-1 female mice. Liver and spleen have the highest levels of Lipid 5, however, significantly lower levels than MC3. Lipid 5 is detected in plasma, lung, and kidney, but not in heart . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Liquid

Specifications

Synonyms

LIPIDV 004 | MS-31197 | nonyl 8-[(8-heptadecan-9-yloxy-8-oxooctyl)-(2-hydroxyethyl)amino]octanoate | P4TKZ45P7A | EX-A6658 | BP-26127 | Octanoic acid, 8-[(2-hydroxyethyl)[8-(nonyloxy)-8-oxooctyl]amino]-, 1-octylnonyl ester | Heptadecan-9-yl 8-((2-hydroxye

Specifications & Purity

Moligand™, ≥98%

Biochemical and Physiological Mechanisms

Lipid 5 is an amino lipid that affords efficient mRNA delivery in rodent and primate models. Lipid 5 shows optimal pharmacokinetics and non-toxic side effects.

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Purity

≥98%

Names and Identifiers

Pubchem Sid

528765390

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/528765390

Canonical Smiles

CCCCCCCCCOC(=O)CCCCCCCN(CCCCCCCC(=O)OC(CCCCCCCC)CCCCCCCC)CCO

IUPAC Name

nonyl 8-[(8-heptadecan-9-yloxy-8-oxooctyl)-(2-hydroxyethyl)amino]octanoate

InChIKey

ABCVHPIKBGRCJA-UHFFFAOYSA-N

INCHI

1S/C44H87NO5/c1-4-7-10-13-16-25-32-41-49-43(47)35-28-21-17-23-30-37-45(39-40-46)38-31-24-18-22-29-36-44(48)50-42(33-26-19-14-11-8-5-2)34-27-20-15-12-9-6-3/h42,46H,4-41H2,1-3H3

Isomeric SMILES

CCCCCCCCCOC(=O)CCCCCCCN(CCCCCCCC(=O)OC(CCCCCCCC)CCCCCCCC)CCO

Alternate CAS

2089251-33-0

PubChem CID

126697428

Molecular Weight

710.17

Chemical and Physical Properties

• Solubility: DMSO : 100 mg/mL (140.81 mM; Need ultrasonic)
• Sensitivity: Moisture sensitive，Light sensitive
• Molecular Weight: 710.200 g/mol
• XLogP3: 15.500
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 43
• Exact Mass: 709.658 Da
• Monoisotopic Mass: 709.658 Da
• Topological Polar Surface Area: 76.100 Ų
• Heavy Atom Count: 50
• Formal Charge: 0
• Complexity: 686.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1