≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
LY2584702 Tosylate LY2584702 Tosylate is a selective, ATP-competitive p70S6K inhibitor with IC50 of 4 nM. Phase 1.
Targets
p70S6K (Cell-free assay) 4 nM
In vitro
In HCT116 colon cancer cells, LY2584702 inhibits phosphorylation of the S6 ribosomal protein (pS6) with IC50 of 0.1-0.24 μM. LY2584702 has significant synergistic effects when combined with EGFR inhibitor erlotinib or with the mTOR inhibitor everolimus.
In vivo
LY2584702 (12.5 mg/kg BID), demonstrates significant antitumor efficacy in both U87MG glioblastoma and HCT116 colon carcinoma xenograft models.
| Pubchem Sid | 504770679 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504770679 |
| Canonical Smiles | CC1=CC=C(C=C1)S(=O)(=O)O.CN1C=C(N=C1C2CCN(CC2)C3=NC=NC4=C3C=NN4)C5=CC(=C(C=C5)F)C(F)(F)F |
| IUPAC Name | 4-[4-[4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methylimidazol-2-yl]piperidin-1-yl]-1H-pyrazolo[3,4-d]pyrimidine;4-methylbenzenesulfonic acid |
| InChIKey | HDYUXDNMHBQKAU-UHFFFAOYSA-N |
| INCHI | 1S/C21H19F4N7.C7H8O3S/c1-31-10-17(13-2-3-16(22)15(8-13)21(23,24)25)29-19(31)12-4-6-32(7-5-12)20-14-9-28-30-18(14)26-11-27-20;1-6-2-4-7(5-3-6)11(8,9)10/h2-3,8-12H,4-7H2,1H3,(H,26,27,28,30);2-5H,1H3,(H,8,9,10) |
| Isomeric SMILES | CC1=CC=C(C=C1)S(=O)(=O)O.CN1C=C(N=C1C2CCN(CC2)C3=NC=NC4=C3C=NN4)C5=CC(=C(C=C5)F)C(F)(F)F |
| Molecular Weight | 617.62 |
| Reaxy-Rn | 18671815 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=18671815&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organoheterocyclic compounds |
| Class | Azoles |
| Subclass | Imidazoles |
| Intermediate Tree Nodes | Substituted imidazoles |
| Direct Parent | Phenylimidazoles |
| Alternative Parents | p-Methylbenzenesulfonates Trifluoromethylbenzenes Tosyl compounds Pyrazolo[3,4-d]pyrimidines 1-sulfo,2-unsubstituted aromatic compounds Benzenesulfonyl compounds 1,2,4-trisubstituted imidazoles Dialkylarylamines Aminopyrimidines and derivatives Fluorobenzenes Piperidines Aryl fluorides Imidolactams N-substituted imidazoles Heteroaromatic compounds Organosulfonic acids Pyrazoles Sulfonyls Azacyclic compounds Organofluorides Organopnictogen compounds Hydrocarbon derivatives Alkyl fluorides Organic oxides |
| Molecular Framework | Not available |
| Substituents | P-methylbenzenesulfonate - 4-phenylimidazole - 5-phenylimidazole - Trifluoromethylbenzene - Benzenesulfonate - Tosyl compound - Pyrazolo[3,4-d]pyrimidine - Benzenesulfonyl group - 1-sulfo,2-unsubstituted aromatic compound - Pyrazolopyrimidine - Arylsulfonic acid or derivatives - Dialkylarylamine - Trisubstituted imidazole - 1,2,4-trisubstituted-imidazole - Fluorobenzene - Halobenzene - Toluene - Aminopyrimidine - Aryl fluoride - Aryl halide - Monocyclic benzene moiety - N-substituted imidazole - Piperidine - Imidolactam - Pyrimidine - Benzenoid - Sulfonyl - Heteroaromatic compound - Organosulfonic acid - Organosulfonic acid or derivatives - Organic sulfonic acid or derivatives - Pyrazole - Azacycle - Organopnictogen compound - Organic oxygen compound - Hydrocarbon derivative - Organic oxide - Alkyl halide - Organohalogen compound - Organic nitrogen compound - Alkyl fluoride - Organofluoride - Organonitrogen compound - Organosulfur compound - Aromatic heteropolycyclic compound |
| Description | This compound belongs to the class of organic compounds known as phenylimidazoles. These are polycyclic aromatic compounds containing a benzene ring linked to an imidazole ring through a CC or CN bond. |
| External Descriptors | Not available |
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Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 K2223445 | Certificate of Analysis | Sep 24, 2025 | L413819 |
| K2223452 | Certificate of Analysis | Sep 24, 2025 | L413819 |
| K2223453 | Certificate of Analysis | Sep 24, 2025 | L413819 |
| K2223455 | Certificate of Analysis | Sep 24, 2025 | L413819 |
| K2223460 | Certificate of Analysis | Sep 24, 2025 | L413819 |
| K2223461 | Certificate of Analysis | Sep 24, 2025 | L413819 |
| Solubility | Solubility (25°C) In vitro DMSO: 7 mg/mL warmed with 50ºC Water: bath (11.33 mM); Water: Insoluble; Ethanol: Insoluble; |
|---|---|
| Molecular Weight | 617.600 g/mol |
| XLogP3 | |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 12 |
| Rotatable Bond Count | 4 |
| Exact Mass | 617.183 Da |
| Monoisotopic Mass | 617.183 Da |
| Topological Polar Surface Area | 138.000 Ų |
| Heavy Atom Count | 43 |
| Formal Charge | 0 |
| Complexity | 850.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 2 |
