10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Protected from light,Desiccated,Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
Lys-[Des-Arg9]Bradykinin TFA, a naturally occurring kinin, is a potent and highly selective bradykinin B1 receptor agonist with a K i of 0.12 nM, 1.7 nM and 0.23 nM for human , mouse and rabbit B1 receptors , respectively. Lys-[Des-Arg9]Bradykinin TFA has low inhibitory activity on B2 receptors
In Vitro
Lys-[Des-Arg9]Bradykinin is formed by the proteolytic cleavage of bradykinin, exerts its effects through bradykinin B1 receptor (B1R). Lys-[Des-Arg9]Bradykinin (Lda-BK; 10 μM) enhances the secretion of IL-12p70 and inhibits the secretion of IL-12p40 by mature hMo-DCs. Pretreatment with Lys-[Des-Arg9]Bradykinin treatment reduces the migration of mature hMo-DCs toward medium alone, suggesting that Lys-[Des-Arg9]Bradykinin may inhibit the chemokinesis of mature hMo-DCs. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Lys-[Des-Arg9]Bradykinin (1 μg; intra-artenal injection; New Zealand White rabbits) treatment reduces peripheral vascular resistance in LPS-induced rabbits, but the effect is brief (T 1/2 is 118-195 s). MCE has not independently confirmed the accuracy of these methods. They are for reference only.
IC50& Target:Bradykinin B1 Receptor (B1R)
Specifications
Specifications & Purity
10mM in DMSO
Biochemical and Physiological Mechanisms
Lys-[Des-Arg9]Bradykinin TFA, a naturally occurring kinin, is a potent and highly selective bradykinin B1 receptor agonist with a K i of 0.12 nM, 1.7 nM and 0.23 nM for human , mouse and rabbit B1 receptors , respectively. Lys-[Des-Arg9]Bradykinin TFA ha
Storage
Protected from light, Desiccated, Store at -80°C
Shipped In
Dry ice packs + Cold packs
This product requires cold chain shipping. Ground and other economy services are not available.
Names and Identifiers
Alternate CAS
71800-36-7（free base）
Molecular Weight
1032.21 (free base)
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
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