Methyl-β-cyclodextrin（MβCD） - average Mn 1310 , CAS No.128446-36-6

CAS: 128446-36-6 Cat. No.: M102038 EC Number: 603-270-3 PubChem CID: 51051622

GRADE & PURITY average Mn 1310

Synonyms

MEBCD | Methyl-β-CD | Methyl-beta-cyclodextrin

Storage

Room temperature

Shipped In

Normal

Overview

​Methyl-β-cyclodextrin (MβCD) is a macrocyclic compound that can form inclusion complexes with a number of guest molecules. It shows higher solubility in aqueous solutions and greater solubilizing and complexing power compared to the parent β-cyclodextrin. MβCD can be used to enhance the enzyme activity and enantioselectivity of subtilizing enzyme in organic solvents. 

Application:
Methyl-β-cyclodextrin is a cholesterol-removing agent mainly used for lipid raft disruption.[4] It may also be used for detergent removal from protein-lipid-detergent ternary mixture to produce 2D membrane protein crystals due to its high solubility and affinity for detergents generally used in membrane protein chemistry.
Methyl-β-cyclodextrin may be used as:
A buffer additive for the effective separation of aminophospholipids by modified micellar electrokinetic capillary chromatography (MEKC) coupled with laser-induced fluorescence detection.
A mobile phase additive for the analysis of R,S-naproxen mixtures in commercial tablet formulations by conventional and nano-liquid chromatography (nano-LC).
An analytical standard for the determination of the analyte in biological samples by high performance liquid chromatography (HPLC).
A chiral selector for the resolution of repaglinide enantiomers in pharmaceutical formulations by capillary electrophoresis.

Specifications

Synonyms

MEBCD | Methyl-β-CD | Methyl-beta-cyclodextrin

Specifications & Purity

average Mn 1310

Storage

Room temperature

Shipped In

Normal

Names and Identifiers

• Pubchem Sid: 488201479
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488201479
• Isomeric SMILES: CO[C@H]1[C@@H]([C@H]2[C@H](O[C@@H]1O[C@@H]3[C@H](O[C@@H]([C@H]([C@@H]3OC)OC)O[C@@H]4[C@H](O[C@@H]([C@H]([C@@H]4OC)OC)O[C@@H]5[C@H](O[C@@H]([C@H]([C@@H]5OC)OC)O[C@@H]6[C@H](O[C@@H]([C@H]([C@@H]6OC)OC)O[C@@H]7[C@H](O[C@@H]([C@H]([C@@H]7OC)OC)O[C@@H]8[C@H](O[C@H](O2)[C@H]([C@@H]8O)OC)CO)CO)CO)CO)CO)CO)CO)O
• WGK Germany: 3
• PubChem CID: 51051622

Chemical and Physical Properties

• Solubility: Soluble in water
• Specific Rotation[α]: [α]25/D +159°, c = 1 in H2O
• Flash Point(°F): 368.6 °F
• Flash Point(°C): 63℃
• Melt Point(°C): 180-182 °C
• Molecular Weight: 1303.300 g/mol
• XLogP3: -8.600
• Hydrogen Bond Donor Count: 9
• Hydrogen Bond Acceptor Count: 35
• Rotatable Bond Count: 19
• Exact Mass: 1302.56 Da
• Monoisotopic Mass: 1302.56 Da
• Topological Polar Surface Area: 422.000 Ų
• Heavy Atom Count: 89
• Formal Charge: 0
• Complexity: 2050.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 35
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1