ML-109 - Moligand™, 10mM in DMSO , CAS No.1186649-91-1

CAS: 1186649-91-1 Cat. No.: M656637 Formula: C₃₁H₂₉N₃O₅ Molecular Weight: 523.58 PubChem CID: 25246343

GRADE & PURITY Moligand™, 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

ML-109 is a potent and full thyroid stimulating hormone receptor (TSHR) agonist, with an EC 50 of 40 nM.

In Vitro

ML-109 (Compound 2) is a full agonist at TSHR with an EC 50 of 40 nM and, like compound 1, it has no activity at FSHR or LHCGR. ML-109 contains an aminal, a functional group that is subject to hydrolysis and/or other degradation mechanisms. ML-109 is surprisingly stable at neutral and basic conditions (t 1/2 of ~16 h) but is found to degrade at low pH (t 1/2 of ~3 h). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:EC50: 40 nM (TSHR)

Specifications

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

ML-109 is a potent and full thyroid stimulating hormone receptor (TSHR) agonist, with an EC 50 of 40 nM.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

AGONIST

Names and Identifiers

• Isomeric SMILES: CC(=O)NC1=CC=C(C=C1)OCC2=C(C=CC(=C2)C3NC4=C(C(=CC=C4)O)C(=O)N3CC5=CC=CC=C5)OC
• Alternate CAS: 1186649-91-1
• PubChem CID: 25246343
• Molecular Weight: 523.58

Associated Targets(Human)

TSHR Tclin Thyrotropin receptor (1 Activities)

Discover Target: TSHR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)