Mosloflavone - Moligand™, ≥99% , CAS No.740-33-0

CAS: 740-33-0 Cat. No.: M647485 Formula: C₁₇H₁₄O₅ Molecular Weight: 298.29 PubChem CID: 471722

GRADE & PURITY Moligand™, ≥99%

Synonyms

DTXSID00224789 | AC-34609 | BAICALEIN-6,7-DIMETHYL ETHER | SCHEMBL971985 | ESTRA-1,3,5(10)-TRIENE-3,17-DIOL, 16-(FLUORO-18F)-, (16alpha,17beta)- | SIVAITYPYQQYAP-UHFFFAOYSA-N | FT-0663427 | Mosloflavone | 4H-1-Benzopyran-4-one, 5-hydroxy-6,7-dimethoxy-2-p

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Mosloflavone is a flavonoid isolated from Scutellaria baicalensis Georgi with  anti-EV71 activity. Mosloflavone  inhibits VP2 virus replication and protein expression during the initial stage of virus infection and inhibits viral VP2 capsid protein synthesis. Mosloflavone is a promising biocide and inhibits P. aeruginosa virulence and biofilm formation.

In Vitro

Mosloflavone shows promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC 50 values of 16.4 uM and 6.4 uM, respectively; inhibits TNF-α, IL-1β and iNOS levels in the supernatant of mouse macrophage cell line J774A as a dose-dependent manner, it also can be used as a starting point to discover lead structures for treatment of inflammatory and immunomodulatory diseases. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:IC50: EV71,bacterial

Specifications

Synonyms

DTXSID00224789 | AC-34609 | BAICALEIN-6,7-DIMETHYL ETHER | SCHEMBL971985 | ESTRA-1,3,5(10)-TRIENE-3,17-DIOL, 16-(FLUORO-18F)-, (16alpha,17beta)- | SIVAITYPYQQYAP-UHFFFAOYSA-N | FT-0663427 | Mosloflavone | 4H-1-Benzopyran-4-one, 5-hydroxy-6,7-dimethoxy-2-p

Specifications & Purity

Moligand™, ≥99%

Biochemical and Physiological Mechanisms

Mosloflavone is a flavonoid isolated from Scutellaria baicalensis Georgi with xa0anti-EV71 activity. Mosloflavonexa0 inhibits VP2 virus replication and protein expression during the initial stage of virus infection and inhibits viral VP2 capsid protein s

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

INHIBITOR

Purity

≥99%

Names and Identifiers

Pubchem Sid

528765650

Canonical Smiles

COC1=C(C(=C2C(=C1)OC(=CC2=O)C3=CC=CC=C3)O)OC

IUPAC Name

5-hydroxy-6,7-dimethoxy-2-phenylchromen-4-one

InChIKey

SIVAITYPYQQYAP-UHFFFAOYSA-N

INCHI

1S/C17H14O5/c1-20-14-9-13-15(16(19)17(14)21-2)11(18)8-12(22-13)10-6-4-3-5-7-10/h3-9,19H,1-2H3

Isomeric SMILES

COC1=C(C(=C2C(=C1)OC(=CC2=O)C3=CC=CC=C3)O)OC

PubChem CID

471722

Molecular Weight

298.29

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Phenylpropanoids and polyketides
    • Class Flavonoids
      • Subclass O-methylated flavonoids

• Kingdom: Organic compounds
• Superclass: Phenylpropanoids and polyketides
• Class: Flavonoids
• Subclass: O-methylated flavonoids
• Intermediate Tree Nodes: Not available
• Direct Parent: 7-O-methylated flavonoids
• Alternative Parents: 6-O-methylated flavonoids Flavones 5-hydroxyflavonoids Chromones Anisoles Pyranones and derivatives Alkyl aryl ethers 1-hydroxy-4-unsubstituted benzenoids Benzene and substituted derivatives Vinylogous acids Heteroaromatic compounds Oxacyclic compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: 6-methoxyflavonoid-skeleton - 7-methoxyflavonoid-skeleton - 5-hydroxyflavonoid - Flavone - Hydroxyflavonoid - Chromone - Benzopyran - 1-benzopyran - Anisole - 1-hydroxy-4-unsubstituted benzenoid - Alkyl aryl ether - Pyranone - Benzenoid - Pyran - Monocyclic benzene moiety - Vinylogous acid - Heteroaromatic compound - Oxacycle - Organoheterocyclic compound - Ether - Organic oxide - Organic oxygen compound - Organooxygen compound - Hydrocarbon derivative - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as 7-o-methylated flavonoids. These are flavonoids with methoxy groups attached to the C7 atom of the flavonoid backbone.
• External Descriptors: Flavones and Flavonols

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

KB 3-1 (1143 Activities)

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MCF7 (126967 Activities)

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H9 (1832 Activities)

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NCI-H460 (60772 Activities)

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SF-268 (49410 Activities)

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KB (17409 Activities)

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Associated Targets(non-human)

Staphylococcus aureus (210822 Activities)

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Klebsiella aerogenes (4963 Activities)

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Bacillus sp. (164 Activities)

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Bacillus subtilis (32866 Activities)

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HT-22 (3261 Activities)

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Avian myoblastosis virus polyprotein II (68 Activities)

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Mechanisms of Action

Chemical and Physical Properties

• Solubility: DMSO : 50 mg/mL (167.62 mM; Need ultrasonic)
• Sensitivity: Light sensitive
• Flash Point(°F): Not applicable
• Flash Point(°C): Not applicable
• Molecular Weight: 298.290 g/mol
• XLogP3: 3.300
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 298.084 Da
• Monoisotopic Mass: 298.084 Da
• Topological Polar Surface Area: 65.000 Ų
• Heavy Atom Count: 22
• Formal Charge: 0
• Complexity: 440.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1