N-lauroyl-D-erythro-sphingosine - ≥98% , CAS No.74713-60-3

CAS: 74713-60-3 Cat. No.: N130618 Molecular Weight: 481.794

GRADE & PURITY ≥98%

Synonyms

AS-60559 | N-[(2S,3R,4E)-1,3-dihydroxyoctadec-4-en-2-yl]dodecanamide | AKOS037645391 | HY-100353 | LMSP02010002 | C12 Ceramide (d18:1/12:0), N-lauroyl-D-erythro-sphingosine, powder | C12 Ceramide;Ceramide 12; N-Lauroyl-D-erythro-sphingosine; N-Laurylsphin

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Specifications

Synonyms

AS-60559 | N-[(2S, 3R, 4E)-1, 3-dihydroxyoctadec-4-en-2-yl]dodecanamide | AKOS037645391 | HY-100353 | LMSP02010002 | C12 Ceramide (d18:1/12:0), N-lauroyl-D-erythro-sphingosine, powder | C12 Ceramide;Ceramide 12; N-Lauroyl-D-erythro-sphingosine; N-Laurylsphin

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

C12:0-Sphingosine ceramide analog. For use in Farber disease studies, in sphingolipid ceramide studies and as internal standard.

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥98%

Names and Identifiers

• Canonical Smiles: CCCCCCCCCCCCCC=CC(C(CO)NC(=O)CCCCCCCCCCC)O
• IUPAC Name: N-[(E,2S,3R)-1,3-dihydroxyoctadec-4-en-2-yl]dodecanamide
• InChIKey: HXFPPRPLRSPNIB-VARSQMIESA-N
• INCHI: 1S/C30H59NO3/c1-3-5-7-9-11-13-14-15-16-18-19-21-23-25-29(33)28(27-32)31-30(34)26-24-22-20-17-12-10-8-6-4-2/h23,25,28-29,32-33H,3-22,24,26-27H2,1-2H3,(H,31,34)/b25-23+/t28-,29+/m0/s1
• Isomeric SMILES: CCCCCCCCCCCCC/C=C/[C@H]([C@H](CO)NC(=O)CCCCCCCCCCC)O
• Molecular Weight: 481.794
• Reaxy-Rn: 33085079
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=33085079&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Lipids and lipid-like molecules
    • Class Sphingolipids
      • Subclass Ceramides

• Kingdom: Organic compounds
• Superclass: Lipids and lipid-like molecules
• Class: Sphingolipids
• Subclass: Ceramides
• Intermediate Tree Nodes: Not available
• Direct Parent: Ceramides
• Alternative Parents: N-acyl amines Secondary carboxylic acid amides Secondary alcohols Primary alcohols Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Ceramide - Fatty amide - N-acyl-amine - Fatty acyl - Carboxamide group - Secondary alcohol - Secondary carboxylic acid amide - Carboxylic acid derivative - Primary alcohol - Organooxygen compound - Organonitrogen compound - Organic oxide - Organopnictogen compound - Organic oxygen compound - Alcohol - Organic nitrogen compound - Carbonyl group - Hydrocarbon derivative - Aliphatic acyclic compound
• Description: This compound belongs to the class of organic compounds known as ceramides. These are lipid molecules containing a sphingosine in which the amine group is linked to a fatty acid.
• External Descriptors: N-acylsphingosines (ceramides)

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Molecular Weight: 481.800 g/mol
• XLogP3: 10.700
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 26
• Exact Mass: 481.449 Da
• Monoisotopic Mass: 481.449 Da
• Topological Polar Surface Area: 69.600 Ų
• Heavy Atom Count: 34
• Formal Charge: 0
• Complexity: 452.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 2
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 1
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 1
• Covalently-Bonded Unit Count: 1

References

1. Jie Zhang, Xiaoling Zang, Peng Jiao, Jiangyu Wu, Wei Meng, Lizhen Zhao, Zhihua Lv.  (2024)  Alterations of Ceramides, Acylcarnitines, GlyceroLPLs, and Amines in NSCLC Tissues.  JOURNAL OF PROTEOME RESEARCH,      [PMID:39317643] [10.1021/acs.jproteome.4c00344]