NCGC00247743 - 10mM in DMSO , CAS No.1435192-04-3

CAS: 1435192-04-3 Cat. No.: N656642 Molecular Weight: 391.51 PubChem CID: 89564218

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

NCGC00247743 is a histone lysine demethylase KDM4 inhibitor.

In Vitro

Based on structure-activity relationship studies, a series of chemical compounds are derived from 8-hydroxyquinoline (8HQ) and shown to be active inhibitors of KDM4E and KDM4A. The effect of these compounds is tested on the growth of LNCaP cells and NCGC00247751 (A1), NCGC00244536 (B3), and NCGC00247743 (I9) are selected. These inhibitors inhibit LNCaP cell growth with IC 50 s in the μM range. These compounds also inhibit the enzymatic activity of other KDM4 isoforms although, interestingly, the potency and efficacy of B3 and A1 for KDM4A, 4C, and 4D are lower compared to that of NCGC00247743 (I9), suggesting a potential selectivity of the inhibitors for different isoforms of KDM4. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:KDM4

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

NCGC00247743 is a histone lysine demethylase KDM4 inhibitor.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Names and Identifiers

• Isomeric SMILES: CN(C)CCCCCCNC(=O)C1=CC=CC(=C1)C2=CC(=C3C(=C2)C=CC=N3)O
• PubChem CID: 89564218
• Molecular Weight: 391.51