Nimbolide - ≥97% , CAS No.25990-37-8

CAS: 25990-37-8 Cat. No.: N275747 Molecular Weight: 466.52 EC Number: 874-681-5

COA

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Nimbolide - ≥97% CAS No(25990-37-8) by Aladdin Scientific

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AVAILABLE TO ORDER

GRADE & PURITY ≥97%

Synonyms

F82256 | XN164985 | J-016215 | Methyl 2-[(1R,2S,4R,6R,9R,10S,11R,15R,18R)-6-(furan-3-yl)-7,9,11,15-tetramethyl-12,16-dioxo-3,17-dioxapentacyclo[9.6.1.02,9.04,8.015,18]octadeca-7,13-dien-10-yl]acetate | NCI60_002662 | FT-0672734 | MEGxp0_001495 | NSC309909

Storage

Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

Overview Specifications Names and Identifiers Documentation Advanced Data Taxonomic Classification 3D Structure Associated Targets(Human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solution Calculators Reviews

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Why this grade

≥97% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -20°C,Desiccated Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Nimbolide is a limonoid tetranortriterpenoid with an α,β-unsaturated ketone system and a δ-lactone ring. 添加Biochem/physiol ActionsNimbolide exhibits anti-malarial, anti-bacterial, and anti-cancer activities. It has been shown to induce apoptosis in osteosarcoma cells and inhibits cell migration of these cells by modulating the expression of integrin αvβ5. In human renal carcinoma cells, nimbolide induced cell cycle arrest, DNA damage, and apoptosis. Nimbolide is a triterpene isolated from Azadirachta indica. It has been shown to modulate autophagy and apoptosis in pancreatic cancer.

Specifications

Synonyms

F82256 | XN164985 | J-016215 | Methyl 2-[(1R, 2S, 4R, 6R, 9R, 10S, 11R, 15R, 18R)-6-(furan-3-yl)-7, 9, 11, 15-tetramethyl-12, 16-dioxo-3, 17-dioxapentacyclo[9.6.1.02, 9.04, 8.015, 18]octadeca-7, 13-dien-10-yl]acetate | NCI60_002662 | FT-0672734 | MEGxp0_001495 | NSC309909

Specifications & Purity

≥97%

Biochemical and Physiological Mechanisms

CyclinA and ERK1/2 inhibitor. Terpenoid lactone derived from Azadirachta indica . Proapoptotic and anticancer activity in vivo .

Storage

Store at -20°C, Desiccated

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥97%

Names and Identifiers

Pubchem Sid	504756456
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504756456
Canonical Smiles	CC1=C2C(CC1C3=COC=C3)OC4C2(C(C5(C6C4OC(=O)C6(C=CC5=O)C)C)CC(=O)OC)C
IUPAC Name	methyl 2-[6-(furan-3-yl)-7,9,11,15-tetramethyl-12,16-dioxo-3,17-dioxapentacyclo[9.6.1.02,9.04,8.015,18]octadeca-7,13-dien-10-yl]acetate
InChIKey	JZIQWNPPBKFOPT-UHFFFAOYSA-N
INCHI	1S/C27H30O7/c1-13-15(14-7-9-32-12-14)10-16-20(13)27(4)17(11-19(29)31-5)26(3)18(28)6-8-25(2)22(26)21(23(27)33-16)34-24(25)30/h6-9,12,15-17,21-23H,10-11H2,1-5H3
Isomeric SMILES	CC1=C2C(CC1C3=COC=C3)OC4C2(C(C5(C6C4OC(=O)C6(C=CC5=O)C)C)CC(=O)OC)C
Molecular Weight	466.52
Reaxy-Rn	24722796
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24722796&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Lipids and lipid-like molecules
  - Class Prenol lipids
    - Subclass Triterpenoids

Kingdom	Organic compounds
Superclass	Lipids and lipid-like molecules
Class	Prenol lipids
Subclass	Triterpenoids
Intermediate Tree Nodes	Not available
Direct Parent	Limonoids
Alternative Parents	Naphthofurans Cyclohexenones Gamma butyrolactones Dicarboxylic acids and derivatives Tetrahydrofurans Methyl esters Heteroaromatic compounds Furans Oxacyclic compounds Dialkyl ethers Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Limonoid skeleton - Naphthofuran - Cyclohexenone - Dicarboxylic acid or derivatives - Gamma butyrolactone - Heteroaromatic compound - Methyl ester - Tetrahydrofuran - Furan - Carboxylic acid ester - Ketone - Lactone - Oxacycle - Carboxylic acid derivative - Organoheterocyclic compound - Dialkyl ether - Ether - Hydrocarbon derivative - Organooxygen compound - Carbonyl group - Organic oxide - Organic oxygen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as limonoids. These are highly oxygenated, modified terpenoids with a prototypical structure either containing or derived from a precursor with a 4,4,8-trimethyl-17-furanylsteroid skeleton. All naturally occurring citrus limonoids contain a furan ring attached to the D-ring, at C-17, as well as oxygen containing functional groups at C-3, C-4, C-7, C-16 and C-17.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3D Structure

Associated Targets(Human)

A498 (42825 Activities)

Lot Number	Certificate Type	Date	Item
J2127326	Certificate of Analysis	May 18, 2026	N275747
J2127553	Certificate of Analysis	May 18, 2026	N275747
F2510104	Certificate of Analysis	Mar 17, 2026	N275747
K2309104	Certificate of Analysis	Feb 04, 2026	N275747
J2127320	Certificate of Analysis	Aug 12, 2022	N275747

Solubility	Soluble in DMSO to 100 mM
Molecular Weight	466.500 g/mol
XLogP3	2.200
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	4
Exact Mass	466.199 Da
Monoisotopic Mass	466.199 Da
Topological Polar Surface Area	92.000 Å²
Heavy Atom Count	34
Formal Charge	0
Complexity	1040.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	9
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1