Nω-Hydroxy-nor-L-Arginine Dihydrochloride - Moligand™, ≥97% , CAS No.291758-32-2

CAS: 291758-32-2 Cat. No.: N351768 Molecular Weight: 249.1

GRADE & PURITY Moligand™, ≥97%

Synonyms

(2S)-2-Amino-4-(((hydroxyamino)iminomethyl)amino)butanoic acid | (2S)-2-amino-4-[(E)-2-hydroxycarbamimidamido]butanoic acid | N.OMEGA.-HYDROXY-NOR-L-ARGININE | CHEBI:191070 | F0001-2381 | J842.499C | Q27088086 | Butanoic acid,2-amino-4-[[(hydroxyamino)imi

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Overview

Competitive, reversible inhibitor of arginase. Neither a substrate nor an inhibitor for iNOS and useful for studying interplays between arginase and NOS. More potent than NOHA and homo-NOHA.

Specifications

Synonyms

(2S)-2-Amino-4-(((hydroxyamino)iminomethyl)amino)butanoic acid | (2S)-2-amino-4-[(E)-2-hydroxycarbamimidamido]butanoic acid | N.OMEGA.-HYDROXY-NOR-L-ARGININE | CHEBI:191070 | F0001-2381 | J842.499C | Q27088086 | Butanoic acid, 2-amino-4-[[(hydroxyamino)imi

Specifications & Purity

Moligand™, ≥97%

Storage

Store at -20°C, Argon charged

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

INHIBITOR

Purity

≥97%

Names and Identifiers

• Canonical Smiles: C(CN=C(N)NO)C(C(=O)O)N
• IUPAC Name: (2S)-2-amino-4-[[amino-(hydroxyamino)methylidene]amino]butanoic acid
• InChIKey: KOBHCUDVWOTEKO-VKHMYHEASA-N
• INCHI: 1S/C5H12N4O3/c6-3(4(10)11)1-2-8-5(7)9-12/h3,12H,1-2,6H2,(H,10,11)(H3,7,8,9)/t3-/m0/s1
• Isomeric SMILES: C(CN=C(N)NO)[C@@H](C(=O)O)N
• Molecular Weight: 249.1
• Reaxy-Rn: 33050234
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=33050234&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Class Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Amino acids and derivatives
          • Level6 Alpha amino acids and derivatives
            • Level7 Alpha amino acids
              • Level8 L-alpha-amino acids

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Class: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Amino acids and derivatives - Alpha amino acids and derivatives - Alpha amino acids
• Direct Parent: L-alpha-amino acids
• Alternative Parents: N-hydroxyguanidines Fatty acids and conjugates Amino acids Monocarboxylic acids and derivatives Carboxylic acids Carboximidamides Organopnictogen compounds Organic oxides Monoalkylamines Imines Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: L-alpha-amino acid - N-hydroxyguanidine - Fatty acid - Guanidine - Amino acid - Carboxylic acid - Monocarboxylic acid or derivatives - Carboximidamide - Amine - Hydrocarbon derivative - Organic oxide - Primary amine - Organooxygen compound - Organonitrogen compound - Organopnictogen compound - Primary aliphatic amine - Imine - Organic oxygen compound - Organic nitrogen compound - Carbonyl group - Aliphatic acyclic compound
• Description: This compound belongs to the class of organic compounds known as l-alpha-amino acids. These are alpha amino acids which have the L-configuration of the alpha-carbon atom.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

ARG2 Tchem Arginase-2, mitochondrial (2 Activities)

Discover Target: ARG2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ARG1 Tchem Arginase-1 (2 Activities)

Discover Target: ARG1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Associated Targets(non-human)

Rattus norvegicus (775804 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ARG1 Arginase-1 (70 Activities)

Discover Target: ARG1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Refractive Index: n20D~1.62 (Predicted)
• Specific Rotation[α]: α24D+14°±2°, c = 1 in 80% acetic acid
• Molecular Weight: 176.170 g/mol
• XLogP3: -4.600
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 176.091 Da
• Monoisotopic Mass: 176.091 Da
• Topological Polar Surface Area: 134.000 Ų
• Heavy Atom Count: 12
• Formal Charge: 0
• Complexity: 182.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1