Norcantharidin - 10mM in DMSO , CAS No.29745-04-8

CAS: 29745-04-8 Cat. No.: N423059 Molecular Weight: 168.15 EC Number: 681-692-7

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Norcantharidin - 10mM in DMSO CAS No(29745-04-8) by Aladdin Scientific

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AVAILABLE TO ORDER

GRADE & PURITY 10mM in DMSO

Synonyms

AKOS006276813 | 4,7-EPOXYISOBENZOFURAN-1,3-DIONE, HEXAHYDRO-, (3A.ALPHA.,4.BETA.,7.BETA.,7A.ALPHA.)- | CGA-110752 | Demethylcantharidin | ( inverted exclamation markA)-NCTD | Z1198158002 | HY-N2108 | NSC-59023 | UNII-8452E71EO7 | N0914 | (1S,2R,6S,7R)-4,1

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Specifications Names and Identifiers Documentation Advanced Data Taxonomic Classification 3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Citations of This Product References Solution Calculators Reviews

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Why this grade

10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 6 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Specifications

Synonyms

AKOS006276813 | 4, 7-EPOXYISOBENZOFURAN-1, 3-DIONE, HEXAHYDRO-, (3A.ALPHA., 4.BETA., 7.BETA., 7A.ALPHA.)- | CGA-110752 | Demethylcantharidin | ( inverted exclamation markA)-NCTD | Z1198158002 | HY-N2108 | NSC-59023 | UNII-8452E71EO7 | N0914 | (1S, 2R, 6S, 7R)-4, 1

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Norcantharidin is a potential antitumor agent. Norcantharidin helps to block SK-N-SH neuroblastoma cell growth by stimulating autophagy and apoptosis.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

Canonical Smiles	C1CC2C3C(C1O2)C(=O)OC3=O
IUPAC Name	(1R,2S,6R,7S)-4,10-dioxatricyclo[5.2.1.02,6]decane-3,5-dione
InChIKey	JAABVEXCGCXWRR-FBXFSONDSA-N
INCHI	1S/C8H8O4/c9-7-5-3-1-2-4(11-3)6(5)8(10)12-7/h3-6H,1-2H2/t3-,4+,5-,6+
Isomeric SMILES	C1C[C@H]2[C@H]3[C@@H]([C@@H]1O2)C(=O)OC3=O
Molecular Weight	168.15
Reaxy-Rn	162827
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=162827&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Furofurans

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Furofurans
Subclass	Not available
Intermediate Tree Nodes	Not available
Direct Parent	Furofurans
Alternative Parents	Dicarboxylic acids and derivatives Oxolanes Carboxylic acid anhydrides Lactones Oxacyclic compounds Dialkyl ethers Organic oxides Hydrocarbon derivatives Carbonyl compounds
Molecular Framework	Aliphatic heteropolycyclic compounds
Substituents	Furofuran - Dicarboxylic acid or derivatives - Oxolane - Carboxylic acid anhydride - Lactone - Oxacycle - Ether - Dialkyl ether - Carboxylic acid derivative - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Carbonyl group - Aliphatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as furofurans. These are organic compounds containing a two furan rings fused to each other. Furan is a five-membered aromatic ring with four carbon atoms and one oxygen atom.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3D Structure

Associated Targets(Human)

PPP1CC Tchem Serine/threonine protein phosphatase PP1-gamma catalytic subunit (63 Activities)

Discover Target: PPP1CC

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Homo sapiens (32628 Activities)

Sensitivity	Moisture sensitive
Melt Point(°C)	111-117（℃）
Molecular Weight	168.150 g/mol
XLogP3	-0.100
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	0
Exact Mass	168.042 Da
Monoisotopic Mass	168.042 Da
Topological Polar Surface Area	52.600 Å²
Heavy Atom Count	12
Formal Charge	0
Complexity	246.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	4
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

1. Jia Wang, Xiange Huang, Hegen Li, Deyue Yan, Wei Huang. (2022) Two Zn(II) coordination polymers with anticancer drug norcantharidin as ligands for cancer chemotherapy. DALTON TRANSACTIONS, 51 (14): (5624-5634). [PMID:35319055] [10.1039/D2DT00300G]
2. Shiqiang Zhang, Yun Yang, Yunwei Hua, Chen Hu, Yi Zhong. (2020) NCTD elicits proapoptotic and antiglycolytic effects on colorectal cancer cells via modulation of Fam46c expression and inhibition of ERK1/2 signaling. Molecular Medicine Reports, 22 (2): (774-782). [PMID:32468032] [10.3892/mmr.2020.11151]
3. Liu Yue, Wang Huirui, Zhan Jie, Sun Jiabo, Sun Yan, Fu Xiaojie, Lv Dongxue, Li Xiuyun, Dong Ting, Lou Hongxiang. (2025) Interaction between CDC6 and Tmod3 accelerates resistance to paclitaxel through focal adhesion assembly. Signal Transduction and Targeted Therapy, 10 (1): (395). [PMID:41339304] [10.1038/s41392-025-02490-7]
4. Yadong Tang, Boxin Huang, Yuqin Dong, Wenlong Wang, Xi Zheng, Wei Zhou, Kun Zhang, Zhiyun Du. (2017) Three-dimensional prostate tumor model based on a hyaluronic acid-alginate hydrogel for evaluation of anti-cancer drug efficacy. JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, [PMID:28583017] [10.1080/09205063.2017.1338502]
5. Ruibing Wu, Hengye Yuan, Yuehua Wang, Xianggang Gou, Wanhua Hou, Zhongzheng Zhou, Xinran Wang, Xiuling Deng, Changshan Wang, Haisheng Wang, Jia Yan. (2025) Norcantharidin inhibits TOP2A expression via H3K27me3 mediated epigenetic regulation to alleviate the progression of hepatocellular carcinoma. Frontiers in Pharmacology, [PMID:40271060] [10.3389/fphar.2025.1541298]
6. Jingming Luo, Yanni Shan, Xudong Fan, Chongyang Wu, Luting Lin, Zeng Wang, Xinjun Cai. (2025) Norcantharidin-Loaded Liposomes Potentiate Radiotherapy by Reprogramming Tumor Vasculature toward Normalization. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, [PMID:40527181] [10.1016/j.bbrc.2025.152129]