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analytical standard, ≥98% Analytical standard for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at 2-8°C Ships Wet ice Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 14 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
| Canonical Smiles | CC1(CCC(C23C1C(C(C45C2CCC(C4O)C(=C)C5=O)(OC3)O)O)O)C |
|---|---|
| IUPAC Name | (1S,2S,5S,8R,9S,10S,11R,15S,18R)-9,10,15,18-tetrahydroxy-12,12-dimethyl-6-methylidene-17-oxapentacyclo[7.6.2.15,8.01,11.02,8]octadecan-7-one |
| InChIKey | SDHTXBWLVGWJFT-XKCURVIJSA-N |
| INCHI | 1S/C20H28O6/c1-9-10-4-5-11-18-8-26-20(25,19(11,14(9)22)15(10)23)16(24)13(18)17(2,3)7-6-12(18)21/h10-13,15-16,21,23-25H,1,4-8H2,2-3H3/t10-,11-,12-,13+,15+,16-,18+,19-,20+/m0/s1 |
| Isomeric SMILES | CC1(CC[C@@H]([C@]23[C@@H]1[C@@H]([C@]([C@]45[C@H]2CC[C@H]([C@H]4O)C(=C)C5=O)(OC3)O)O)O)C |
| WGK Germany | 2 |
| RTECS | NZ8177000 |
| Alternate CAS | 28957-10-0 |
| Molecular Weight | 364.43 |
| Reaxy-Rn | 25328717 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=25328717&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Lipids and lipid-like molecules |
| Class | Prenol lipids |
| Subclass | Diterpenoids |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Kaurane diterpenoids |
| Alternative Parents | Oxanes Secondary alcohols Ketones Hemiacetals Cyclic alcohols and derivatives Polyols Oxacyclic compounds Organic oxides Hydrocarbon derivatives |
| Molecular Framework | Aliphatic heteropolycyclic compounds |
| Substituents | Kaurane diterpenoid - Oxane - Cyclic alcohol - Hemiacetal - Ketone - Secondary alcohol - Oxacycle - Polyol - Organoheterocyclic compound - Organooxygen compound - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Alcohol - Carbonyl group - Aliphatic heteropolycyclic compound |
| Description | This compound belongs to the class of organic compounds known as kaurane diterpenoids. These are diterpene alkaloids with a structure that is based on the kaurane skeleton. Kaurane is a tetracyclic compound that arises by cyclisation of a pimarane precursor followed by rearrangement. It possesses a [3,2,1]-bicyclic ring system with C15-C16 bridge connected to C13, forming the five-membered ring D. |
| External Descriptors | Not available |
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Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Mar 10, 2026 | O111381 | |
| Certificate of Analysis | Nov 13, 2025 | O111381 | |
| Certificate of Analysis | Nov 13, 2025 | O111381 | |
| Certificate of Analysis | Nov 13, 2025 | O111381 | |
| Certificate of Analysis | Sep 18, 2023 | O111381 | |
| Certificate of Analysis | May 12, 2023 | O111381 | |
| Certificate of Analysis | Feb 06, 2023 | O111381 |
| Sensitivity | Heat Sensitive |
|---|---|
| Melt Point(°C) | 248-250°C |
| Molecular Weight | 364.400 g/mol |
| XLogP3 | 0.100 |
| Hydrogen Bond Donor Count | 4 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 0 |
| Exact Mass | 364.189 Da |
| Monoisotopic Mass | 364.189 Da |
| Topological Polar Surface Area | 107.000 Ų |
| Heavy Atom Count | 26 |
| Formal Charge | 0 |
| Complexity | 717.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 9 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
| 1. Jinrong Lin, Zhao Qu, Huanhuan Pu, Li-Sha Shen, Xianguo Yi, Yu-Shan Lin, Rui-Hong Gong, Guo-Qing Chen, Sibao Chen. (2023) In Vitro and In Vivo Anti-Cancer Activity of Lasiokaurin in a Triple-Negative Breast Cancer Model. MOLECULES, 28 (23): (7701). [PMID:38067432] [10.3390/molecules28237701] |
| 2. Chen Yulian, Jiang Huanguo, Zhan Zhikun, Lu Jindi, Gu Tanwei, Yu Ping, Liang Weimin, Zhang Xi, Liu Shuwen, Bi Huichang, Zhong Shilong, Tang Lan. (2023) Restoration of lipid homeostasis between TG and PE by the LXRα-ATGL/EPT1 axis ameliorates hepatosteatosis. Cell Death & Disease, 14 (2): (1-17). [PMID:36746922] [10.1038/s41419-023-05613-6] |
| 3. Jiahui Lin, Xianhui Lai, Xiaoxi Fan, Bozhi Ye, Lingfeng Zhong, Yucong Zhang, Ruiyin Shao, Si Shi, Weijian Huang, Lan Su, Miaomiao Ying. (2022) Oridonin Protects against Myocardial Ischemia–Reperfusion Injury by Inhibiting GSDMD-Mediated Pyroptosis. Genes, 13 (11): (2133). [PMID:36421808] [10.3390/genes13112133] |
| 4. Linglan Yang, Leitao Zhang, Jing Hu, Wenjin Wang, Xiqiang Liu. (2020) Promote anti-inflammatory and angiogenesis using a hyaluronic acid-based hydrogel with miRNA-laden nanoparticles for chronic diabetic wound treatment. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, [PMID:33172616] [10.1016/j.ijbiomac.2020.10.129] |
| 5. Linhao Xu, Yanli Bi, Yizhou Xu, Zhuocheng Zhang, Wenjie Xu, Sisi Zhang, Jian Chen. (2020) Oridonin inhibits the migration and epithelial-to-mesenchymal transition of small cell lung cancer cells by suppressing FAK-ERK1/2 signalling pathway. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 24 (8): (4480-4493). [PMID:32168416] [10.1111/jcmm.15106] |
| 6. Shou-Di He, Sheng-Guang Huang, Hui-Jun Zhu, Xiao-Guang Luo, Kang-Han Liao, Jie-Yao Zhang, Ning Tan, De-Yu Li. (2020) Oridonin suppresses autophagy and survival in rheumatoid arthritis fibroblast-like synoviocytes. PHARMACEUTICAL BIOLOGY, [PMID:31971852] [10.1080/13880209.2020.1711783] |
| 7. Heqi Bu, Dianlei Liu, Junhui Cui, Ke Cai, Feng Shen. (2019) Wnt/β-catenin signaling pathway is involved in induction of apoptosis by oridonin in colon cancer COLO205 cells. Translational Cancer Research, [PMID:35116929] [10.21037/tcr.2019.08.25] |
| 8. Xiaoning Liu, Jingjing Kang, Hui Wang, Tao Huang. (2017) Mitochondrial ROS contribute to oridonin-induced HepG2 apoptosis through PARP activation. Oncology Letters, 15 (3): (2881-2888). [PMID:29435014] [10.3892/ol.2017.7665] |
| 9. Junyan Wang, Minmin Huang, Haihong Hu, Lushan Yu, Su Zeng. (2014) Pregnane X receptor-mediated transcriptional activation of UDP-glucuronosyltransferase 1A1 by natural constituents from foods and herbs. FOOD CHEMISTRY, [PMID:24996308] [10.1016/j.foodchem.2014.05.004] |
| 10. Yang Chen, Wenzhe Xu, Hao Jin, Mengsi Zhang, Shuwei Liu, Yi Liu, Hao Zhang. (2024) Nutritional Glutamine-Modified Iron-Delivery System with Enhanced Endocytosis for Ferroptosis Therapy of Pancreatic Tumors. ACS Nano, [PMID:39512234] [10.1021/acsnano.4c08083] |
| 11. Linhao Xu, Yuxin Jiang, Yanli Bi, Senwen Zheng, Yirong Wu, Yihao Wu, Yizhou Xu, Jian Chen. (2024) Suppression of PERK/eIF2α/CHOP pathway enhances oridonin-induced apoptosis by inhibiting autophagy in Small-Cell lung cancer cells. BIOMEDICINE & PHARMACOTHERAPY, [PMID:38713951] [10.1016/j.biopha.2024.116684] |
| 12. Xiangjuan Wei, Mengyuan Wang, Xiaocong Dong, Yichen He, Wenbin Nan, Shenglu Ji, Mengyuan Zhao, Haodang Chang, Hongliang Wei, Dan Ding, Hongli Chen. (2025) Internal-External Homologous Drug-Loaded Exosome-Like Nanovesicles Released from Semi-IPN Hydrogel Enhancing Wound Healing of Chemoradiotherapy-Induced Oral Mucositis. International Journal of Nanomedicine, [PMID:40201151] [10.2147/IJN.S508530] |
| 13. Wenqian Li, Jiuliang Zhang, Qiang Chen, Biaobiao Luo, Bo Zhou, Jun Wang, Yang Yang, Yi Liu, Shuixiu Wen, De-Xin Kong, Jian Chen, Shaozhong Wei, Pierre Duez, Avez Sharipov, Yan Li, Xuebo Hu. (2025) Treatment of Parkinson’s Disease with an Anti-Inflammasome NLRP3 Inhibitor Derived from a Natural Product. ACS Pharmacology & Translational Science, [PMID:41262577] [10.1021/acsptsci.5c00109] |
| 14. Yao Wang, Junhua Qiu, Chengwei Wang, Ruiyu Yang, Fuyou Guo, Tian Li, Shili Li, Lei Yang, Wei Ding. (2026) Sustainable Strategy of Natural trans-Anethole in Controlling Bacterial Wilt: Virulence Suppression and Beneficial Microbiome Enrichment. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, [PMID:41568748] [10.1021/acs.jafc.5c13627] |
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