Oridonin - analytical standard, ≥98% , CAS No.28957-04-2

CAS: 28957-04-2 Cat. No.: O111381 Molecular Weight: 364.43 EC Number: 631-100-8
AVAILABLE TO ORDER
GRADE & PURITY Analytical standard ? Analytical standard — certified-purity material for quantitative calibration. Use to prepare calibration standards and validate analytical methods. ≥98%
Synonyms
ORIDONIN [INCI] | NSC-250682; Isodonol | Rubescenin | DTXSID201021760 | KAUR-16-EN-15-ONE, 7,20-EPOXY-1,6,7,14-TETRAHYDROXY-, (1.ALPHA.,6.BETA.,7.ALPHA.,14R)- | CHEBI:138236 | 0APJ98UCLQ | Oridonin | UNII-0APJ98UCLQ | H10339 | NSC 250682 | Curator_000006
Storage
Store at 2-8°C
Shipped In
Wet ice
 ·  off list, applied to all prices below.
Size
Status
Price
Qty
20mg
O111381-20mg
1

$75.90

$102.90
Save $27.00 (26.24%)
Enter a quantity for the sizes you want to add.
🧪

Why this grade

analytical standard, ≥98% Analytical standard for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at 2-8°C Ships Wet ice Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 14 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Specifications

Synonyms
ORIDONIN [INCI] | NSC-250682; Isodonol | Rubescenin | DTXSID201021760 | KAUR-16-EN-15-ONE, 7, 20-EPOXY-1, 6, 7, 14-TETRAHYDROXY-, (1.ALPHA., 6.BETA., 7.ALPHA., 14R)- | CHEBI:138236 | 0APJ98UCLQ | Oridonin | UNII-0APJ98UCLQ | H10339 | NSC 250682 | Curator_000006
Specifications & Purity
analytical standard, ≥98%
Storage
Store at 2-8°C
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Grade
Analytical standard
Purity
≥98%
Names and Identifiers
Canonical SmilesCC1(CCC(C23C1C(C(C45C2CCC(C4O)C(=C)C5=O)(OC3)O)O)O)C
IUPAC Name(1S,2S,5S,8R,9S,10S,11R,15S,18R)-9,10,15,18-tetrahydroxy-12,12-dimethyl-6-methylidene-17-oxapentacyclo[7.6.2.15,8.01,11.02,8]octadecan-7-one
InChIKeySDHTXBWLVGWJFT-XKCURVIJSA-N
INCHI1S/C20H28O6/c1-9-10-4-5-11-18-8-26-20(25,19(11,14(9)22)15(10)23)16(24)13(18)17(2,3)7-6-12(18)21/h10-13,15-16,21,23-25H,1,4-8H2,2-3H3/t10-,11-,12-,13+,15+,16-,18+,19-,20+/m0/s1
Isomeric SMILES CC1(CC[C@@H]([C@]23[C@@H]1[C@@H]([C@]([C@]45[C@H]2CC[C@H]([C@H]4O)C(=C)C5=O)(OC3)O)O)O)C
WGK Germany 2
RTECS NZ8177000
Alternate CAS 28957-10-0
Molecular Weight 364.43
Reaxy-Rn 25328717
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=25328717&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassLipids and lipid-like molecules
ClassPrenol lipids
SubclassDiterpenoids
Intermediate Tree Nodes Not available
Direct ParentKaurane diterpenoids
Alternative Parents Oxanes  Secondary alcohols  Ketones  Hemiacetals  Cyclic alcohols and derivatives  Polyols  Oxacyclic compounds  Organic oxides  Hydrocarbon derivatives  
Molecular FrameworkAliphatic heteropolycyclic compounds
Substituents Kaurane diterpenoid - Oxane - Cyclic alcohol - Hemiacetal - Ketone - Secondary alcohol - Oxacycle - Polyol - Organoheterocyclic compound - Organooxygen compound - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Alcohol - Carbonyl group - Aliphatic heteropolycyclic compound
DescriptionThis compound belongs to the class of organic compounds known as kaurane diterpenoids. These are diterpene alkaloids with a structure that is based on the kaurane skeleton. Kaurane is a tetracyclic compound that arises by cyclisation of a pimarane precursor followed by rearrangement. It possesses a [3,2,1]-bicyclic ring system with C15-C16 bridge connected to C13, forming the five-membered ring D.
External Descriptors Not available
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
HL-60 (67320 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
K562 (73714 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KB 3-1 (1143 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MCF7 (126967 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MDA-MB-453 (1139 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MDA-MB-468 (9477 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PC-3 (62116 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RPMI-8226 (44974 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SGC-7901 (2773 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SK-BR-3 (5175 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SW480 (6023 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A549 (127892 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Bel-7402 (4577 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BEL-7404 tumor cell line (165 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NCI/ADR-RES (33767 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
T47D (39041 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HCT-116 (91556 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HepG2 (196354 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NCI-H460 (60772 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HeLa (62764 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MDA-MB-231 (73002 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PBMC (10003 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SMMC-7721 (5516 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HCC1806 (544 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HCC1937 (423 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PLC-PRF-5 (244 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NLRP3 Tchem NACHT, LRR and PYD domains-containing protein 3 (908 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TE-1 (337 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DU-4475 (193 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MGC-803 (6426 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
L02 (4864 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Associated Targets(non-human)
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RAW264.7 (28094 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
H22 (575 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

7 results found

Lot NumberCertificate TypeDateItem
I2208866Certificate of AnalysisMar 10, 2026 O111381
K2526500Certificate of AnalysisNov 13, 2025 O111381
K2526505Certificate of AnalysisNov 13, 2025 O111381
K2526515Certificate of AnalysisNov 13, 2025 O111381
L2103141Certificate of AnalysisSep 18, 2023 O111381
H2124452Certificate of AnalysisMay 12, 2023 O111381
G1918089Certificate of AnalysisFeb 06, 2023 O111381
Chemical and Physical Properties
SensitivityHeat Sensitive
Melt Point(°C)248-250°C
Molecular Weight364.400 g/mol
XLogP30.100
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count6
Rotatable Bond Count0
Exact Mass364.189 Da
Monoisotopic Mass364.189 Da
Topological Polar Surface Area107.000 Ų
Heavy Atom Count26
Formal Charge0
Complexity717.000
Isotope Atom Count0
Defined Atom Stereocenter Count9
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Documents & Articles
Citations of This Product
References
1. Jinrong Lin, Zhao Qu, Huanhuan Pu, Li-Sha Shen, Xianguo Yi, Yu-Shan Lin, Rui-Hong Gong, Guo-Qing Chen, Sibao Chen.  (2023)  In Vitro and In Vivo Anti-Cancer Activity of Lasiokaurin in a Triple-Negative Breast Cancer Model.  MOLECULES,  28  (23): (7701).  [PMID:38067432] [10.3390/molecules28237701]
2. Chen Yulian, Jiang Huanguo, Zhan Zhikun, Lu Jindi, Gu Tanwei, Yu Ping, Liang Weimin, Zhang Xi, Liu Shuwen, Bi Huichang, Zhong Shilong, Tang Lan.  (2023)  Restoration of lipid homeostasis between TG and PE by the LXRα-ATGL/EPT1 axis ameliorates hepatosteatosis.  Cell Death & Disease,  14  (2): (1-17).  [PMID:36746922] [10.1038/s41419-023-05613-6]
3. Jiahui Lin, Xianhui Lai, Xiaoxi Fan, Bozhi Ye, Lingfeng Zhong, Yucong Zhang, Ruiyin Shao, Si Shi, Weijian Huang, Lan Su, Miaomiao Ying.  (2022)  Oridonin Protects against Myocardial Ischemia–Reperfusion Injury by Inhibiting GSDMD-Mediated Pyroptosis.  Genes,  13  (11): (2133).  [PMID:36421808] [10.3390/genes13112133]
4. Linglan Yang, Leitao Zhang, Jing Hu, Wenjin Wang, Xiqiang Liu.  (2020)  Promote anti-inflammatory and angiogenesis using a hyaluronic acid-based hydrogel with miRNA-laden nanoparticles for chronic diabetic wound treatment.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:33172616] [10.1016/j.ijbiomac.2020.10.129]
5. Linhao Xu, Yanli Bi, Yizhou Xu, Zhuocheng Zhang, Wenjie Xu, Sisi Zhang, Jian Chen.  (2020)  Oridonin inhibits the migration and epithelial-to-mesenchymal transition of small cell lung cancer cells by suppressing FAK-ERK1/2 signalling pathway.  JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,  24  (8): (4480-4493).  [PMID:32168416] [10.1111/jcmm.15106]
6. Shou-Di He, Sheng-Guang Huang, Hui-Jun Zhu, Xiao-Guang Luo, Kang-Han Liao, Jie-Yao Zhang, Ning Tan, De-Yu Li.  (2020)  Oridonin suppresses autophagy and survival in rheumatoid arthritis fibroblast-like synoviocytes.  PHARMACEUTICAL BIOLOGY,      [PMID:31971852] [10.1080/13880209.2020.1711783]
7. Heqi Bu, Dianlei Liu, Junhui Cui, Ke Cai, Feng Shen.  (2019)  Wnt/β-catenin signaling pathway is involved in induction of apoptosis by oridonin in colon cancer COLO205 cells.  Translational Cancer Research,      [PMID:35116929] [10.21037/tcr.2019.08.25]
8. Xiaoning Liu, Jingjing Kang, Hui Wang, Tao Huang.  (2017)  Mitochondrial ROS contribute to oridonin-induced HepG2 apoptosis through PARP activation.  Oncology Letters,  15  (3): (2881-2888).  [PMID:29435014] [10.3892/ol.2017.7665]
9. Junyan Wang, Minmin Huang, Haihong Hu, Lushan Yu, Su Zeng.  (2014)  Pregnane X receptor-mediated transcriptional activation of UDP-glucuronosyltransferase 1A1 by natural constituents from foods and herbs.  FOOD CHEMISTRY,      [PMID:24996308] [10.1016/j.foodchem.2014.05.004]
10. Yang Chen, Wenzhe Xu, Hao Jin, Mengsi Zhang, Shuwei Liu, Yi Liu, Hao Zhang.  (2024)  Nutritional Glutamine-Modified Iron-Delivery System with Enhanced Endocytosis for Ferroptosis Therapy of Pancreatic Tumors.  ACS Nano,      [PMID:39512234] [10.1021/acsnano.4c08083]
11. Linhao Xu, Yuxin Jiang, Yanli Bi, Senwen Zheng, Yirong Wu, Yihao Wu, Yizhou Xu, Jian Chen.  (2024)  Suppression of PERK/eIF2α/CHOP pathway enhances oridonin-induced apoptosis by inhibiting autophagy in Small-Cell lung cancer cells.  BIOMEDICINE & PHARMACOTHERAPY,      [PMID:38713951] [10.1016/j.biopha.2024.116684]
12. Xiangjuan Wei, Mengyuan Wang, Xiaocong Dong, Yichen He, Wenbin Nan, Shenglu Ji, Mengyuan Zhao, Haodang Chang, Hongliang Wei, Dan Ding, Hongli Chen.  (2025)  Internal-External Homologous Drug-Loaded Exosome-Like Nanovesicles Released from Semi-IPN Hydrogel Enhancing Wound Healing of Chemoradiotherapy-Induced Oral Mucositis.  International Journal of Nanomedicine,      [PMID:40201151] [10.2147/IJN.S508530]
13. Wenqian Li, Jiuliang Zhang, Qiang Chen, Biaobiao Luo, Bo Zhou, Jun Wang, Yang Yang, Yi Liu, Shuixiu Wen, De-Xin Kong, Jian Chen, Shaozhong Wei, Pierre Duez, Avez Sharipov, Yan Li, Xuebo Hu.  (2025)  Treatment of Parkinson’s Disease with an Anti-Inflammasome NLRP3 Inhibitor Derived from a Natural Product.  ACS Pharmacology & Translational Science,      [PMID:41262577] [10.1021/acsptsci.5c00109]
14. Yao Wang, Junhua Qiu, Chengwei Wang, Ruiyu Yang, Fuyou Guo, Tian Li, Shili Li, Lei Yang, Wei Ding.  (2026)  Sustainable Strategy of Natural trans-Anethole in Controlling Bacterial Wilt: Virulence Suppression and Beneficial Microbiome Enrichment.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:41568748] [10.1021/acs.jafc.5c13627]
Solution Calculators
Reviews

Customer Reviews

Shall we send you a message when we have discounts available?

Remind me later

Thank you! Please check your email inbox to confirm.

Oops! Notifications are disabled.