Osthole - Moligand™, 10mM in DMSO , Channel blocker of TRPV3, CAS No.484-12-8, Channel blocker of TRPV3

CAS: 484-12-8 Cat. No.: O408868 Formula: C₁₅H₁₆O₃ Molecular Weight: 244.29 EC Number: 610-421-7

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

Osthol | 2H-1-Benzopyran-2-one, 7-methoxy-8-(3-methyl-2-buten-1-yl)-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Osthol is an O-methylated coumarin, which is found in the plants such as Cnidium monnieri, Angelica archangelica and Angelica pubescens.
In vitro

Osthol is an O-methylated coumarin which is found in the plants such as Cnidium monnieri, Angelica archangelica and Angelica pubescens. Osthol inhibites platelet aggregation and ATP release induced by ADP, arachidonic acid, PAF, collagen, ionophore A23187 and thrombin in washed rabbit platelets. Osthole mediates cell differentiation through bone morphogenetic protein-2/p38 and extracellular signal-regulated kinase 1/2 pathway in human osteoblast cells and may be a promising agent for treating osteoporosis. Osthole also suppresses the secretion of hepatitis B virus in cell culture by increasing the glycosylation of HBsAg.

In vivo

LD50: Rats >125mg/kg (i.v.); Rabbits >35mg/kg (i.v.); Dogs >150mg/kg (i.v.).
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

Osthol | 2H-1-Benzopyran-2-one, 7-methoxy-8-(3-methyl-2-buten-1-yl)-

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Osthol is an O-methylated coumarin, which is found in the plants such as Cnidium monnieri, Angelica archangelica and Angelica pubescens.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

CHANNEL BLOCKER

Mechanism of action

Channel blocker of TRPV3

Names and Identifiers

Isomeric SMILES

CC(=CCC1=C(C=CC2=C1OC(=O)C=C2)OC)C

WGK Germany

1

RTECS

GN7700000

Alternate CAS

484-12-8

NSC Number

31868

MeSH Entry Terms

7-methoxy-8-(3-methylpent-2-enyl)coumarin;osthol;osthole

Molecular Weight

244.29

Reaxy-Rn

1288399

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1288399&ln=

Associated Targets(Human)

TRPV3 Tchem Transient receptor potential cation channel subfamily V member 3 (1 Activities)

Discover Target: TRPV3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Boil Point(°C): 145～150°C
• Melt Point(°C): 83-84°C

Frequently Asked Questions

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 484-12-8, the molecular formula is C15H16O3, and the molecular weight is 244.29 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.