Palovarotene - 10mM in DMSO , Retinoic acid receptor gamma agonist, CAS No.410528-02-8, Retinoic acid receptor gamma agonist

CAS: 410528-02-8 Cat. No.: P655848 Molecular Weight: 414.54 PubChem CID: 10295295

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Palovarotene is a nuclear retinoic acid receptor γ ( RAR-γ ) agonist.

In Vivo

Palovarotene suppresses post-traumatic chondrogenesis and osteogenesis and mitigated trauma-induced ectopic bone formation. Palovarotene inhibits subcutaneous and intramuscular heterotopic ossification (HO) in mice. Palovarotene is given orally for 14 days at 1 mg/kg/day starting on post-operative day (POD) 1 or POD-5, and HO amount, wound dehiscence and related processes are monitored for up to 84 days post injury. Compared to vehicle-control animals, Palovarotene significantly decreases HO by 50 to 60% regardless of when the treatment started and if infection is present . Starting from day 1 of injury, half of the Acvr1 cR206H/+ mice are treated with Palovarotene by daily gavage for 14 days and the other half received vehicle as control. Analysis by mCT and 3D image reconstruction at day 14 shows that large HO tissue masses have formed in the targeted leg of Acvr1 cR206H/+ mutant mice receiving vehicle, but HO formation is greatly diminished in Palovarotene-treated companions by more than 80% based on bone volume/total volume quantification. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:RAR-γ

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Palovarotene is a nuclear retinoic acid receptor γ ( RAR-γ ) agonist.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

AGONIST

Mechanism of action

Retinoic acid receptor gamma agonist

Product Properties

• ALogP: 6.8

Names and Identifiers

• Isomeric SMILES: CC1(CCC(C2=C1C=C(C(=C2)/C=C/C3=CC=C(C=C3)C(=O)O)CN4C=CC=N4)(C)C)C
• Alternate CAS: 410528-02-8
• PubChem CID: 10295295
• MeSH Entry Terms: Palovarotene;R-667;RG-667;RO-3300074
• Molecular Weight: 414.54