Pamoic acid, also known as embonic acid, is the free acid form of pamoates or embonates. It has shown to have agonist activity for GPR35, an orphan G protein coupled receptor.

Storage

Argon charged, Room temperature

Shipped In

Normal

Grade

Moligand™

Action Type

AGONIST

Mechanism of action

Agonist of GPR35

Purity

≥97%

Names and Identifiers

Pubchem Sid	488180825
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488180825
Canonical Smiles	C1=CC=C2C(=C1)C=C(C(=C2CC3=C(C(=CC4=CC=CC=C43)C(=O)O)O)O)C(=O)O
IUPAC Name	4-[(3-carboxy-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylic acid
InChIKey	WLJNZVDCPSBLRP-UHFFFAOYSA-N
INCHI	1S/C23H16O6/c24-20-16(14-7-3-1-5-12(14)9-18(20)22(26)27)11-17-15-8-4-2-6-13(15)10-19(21(17)25)23(28)29/h1-10,24-25H,11H2,(H,26,27)(H,28,29)
Isomeric SMILES	C1=CC=C2C(=C1)C=C(C(=C2CC3=C(C(=CC4=CC=CC=C43)C(=O)O)O)O)C(=O)O
WGK Germany	3
RTECS	QL2180000
Molecular Weight	388.37
Beilstein	901319
Reaxy-Rn	901319
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=901319&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

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✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

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📊 Datasheet

Quick-reference summary of product specifications and applications.

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🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - Class Naphthalenes
    - Subclass Naphthalenecarboxylic acids and derivatives

Kingdom	Organic compounds
Superclass	Benzenoids
Class	Naphthalenes
Subclass	Naphthalenecarboxylic acids and derivatives
Intermediate Tree Nodes	Not available
Direct Parent	Naphthalenecarboxylic acids
Alternative Parents	Naphthols and derivatives Salicylic acid and derivatives Dicarboxylic acids and derivatives Vinylogous acids Carboxylic acids Organooxygen compounds Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic homopolycyclic compounds
Substituents	2-naphthalenecarboxylic acid - 2-naphthol - Salicylic acid or derivatives - Hydroxybenzoic acid - Dicarboxylic acid or derivatives - Vinylogous acid - Carboxylic acid - Carboxylic acid derivative - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Aromatic homopolycyclic compound
Description	This compound belongs to the class of organic compounds known as naphthalenecarboxylic acids. These are compounds containing a naphthalene moiety, which bears a carboxylic acid group one or more positions. Naphthalene is a bicyclic compound that is made up of two fused benzene ring.
External Descriptors	dicarboxylic acid
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3D Structure

Associated Targets(Human)

GPR35 Tchem G-protein coupled receptor 35 (6 Activities)

Discover Target: GPR35

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADRB2 Tclin Beta-2 adrenergic receptor (11824 Activities)

Discover Target: ADRB2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)

Discover Target: ADRA2A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

AGTR1 Tclin Type-1 angiotensin II receptor (5176 Activities)

Discover Target: AGTR1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

POLB Tchem DNA polymerase beta (23632 Activities)

Discover Target: POLB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)

Discover Target: CYP2D6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

S1PR1 Tclin Sphingosine 1-phosphate receptor Edg-1 (5806 Activities)

Discover Target: S1PR1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GLP1R Tclin Glucagon-like peptide 1 receptor (111429 Activities)

Discover Target: GLP1R

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)

Discover Target: CYP1A2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

C5AR1 Tclin C5a anaphylatoxin chemotactic receptor (2677 Activities)

Discover Target: C5AR1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)

Discover Target: CYP2C9

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)

Discover Target: CYP2C19

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)

Discover Target: CYP3A4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

A498 (42825 Activities)

Lot Number	Certificate Type	Date	Item
C2211483	Certificate of Analysis	Dec 10, 2025	P106763
C2211484	Certificate of Analysis	Dec 10, 2025	P106763
C2211485	Certificate of Analysis	Dec 10, 2025	P106763
C2211486	Certificate of Analysis	Dec 10, 2025	P106763
K2115431	Certificate of Analysis	Aug 13, 2025	P106763
K2115113	Certificate of Analysis	Aug 13, 2025	P106763
K2115112	Certificate of Analysis	Aug 13, 2025	P106763
K2115111	Certificate of Analysis	Aug 13, 2025	P106763
G2426553	Certificate of Analysis	Apr 30, 2024	P106763
G2426554	Certificate of Analysis	Apr 30, 2024	P106763
C1607100	Certificate of Analysis	Nov 01, 2023	P106763
G2322634	Certificate of Analysis	Jun 30, 2023	P106763
G2322638	Certificate of Analysis	Jun 30, 2023	P106763
G2322644	Certificate of Analysis	Jun 30, 2023	P106763
G2322645	Certificate of Analysis	Jun 30, 2023	P106763
G2322646	Certificate of Analysis	Jun 30, 2023	P106763
G2322647	Certificate of Analysis	Jun 30, 2023	P106763
G2322971	Certificate of Analysis	Jun 30, 2023	P106763
G2322984	Certificate of Analysis	Jun 30, 2023	P106763
G2324069	Certificate of Analysis	Jun 30, 2023	P106763
G2324070	Certificate of Analysis	Jun 30, 2023	P106763
D2324715	Certificate of Analysis	May 05, 2023	P106763
D2324705	Certificate of Analysis	Nov 08, 2021	P106763
C2211487	Certificate of Analysis	Nov 08, 2021	P106763

Solubility	Soluble in nitrobenzene, pyridine.Insoluble in water, soluble in nitrobenzene, very slightly soluble in chloroform, insoluble in ether, alcohol, benzene
Melt Point(°C)	≥300°C
Molecular Weight	388.400 g/mol
XLogP3	5.800
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	4
Exact Mass	388.095 Da
Monoisotopic Mass	388.095 Da
Topological Polar Surface Area	115.000 Å²
Heavy Atom Count	29
Formal Charge	0
Complexity	568.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Pamoic acid - Moligand™, ≥97% , Agonist of GPR35, CAS No.130-85-8, Agonist of GPR35

Why this grade

Storage & shipping

Quality documents

Literature proof

Overview

Specifications

Documentation

📋 Safety Data Sheet (SDS)

✅ Certificate of Analysis (COA)

📊 Datasheet

🔬 Specification Sheet

Advanced Data

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