PD 168368 - Moligand™, 10 mM in DMSO , CAS No.204066-82-0

CAS: 204066-82-0 Cat. No.: P1494986 Molecular Weight: 554.65 PubChem CID: 9937534

GRADE & PURITY Moligand™, 10 mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

PD 168368 is a potent, competitive, and selective neuromedin B receptor ( NMB-R ) antagonist with the K i of 15–45 nM. PD 168368 is neuromedin B receptor ( NMBR ; IC 50 =96 nM) / gastrin-releasing peptide receptor ( GRPR IC 50 =3500 nM) antagonist. PD 168368 also is a mixed FPR1/FPR2/FPR3 agonist with EC 50 s of 0.57, 0.24, and 2.7 nM, respectively.

Specifications

Specifications & Purity

Moligand™, 10 mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

ANTAGONIST

Product Properties

• pKa: pKₐ: 11.6 (Predicted), pKₐ: 5.65 (Predicted)
• Ki Data: NMBR: Ki= 0.15 nM (human); GRPR: Ki= 17 nM (human)

Names and Identifiers

• Isomeric SMILES: C[C@](CC1=CNC2=CC=CC=C21)(C(=O)NCC3(CCCCC3)C4=CC=CC=N4)NC(=O)NC5=CC=C(C=C5)[N+](=O)[O-]
• PubChem CID: 9937534
• MeSH Entry Terms: PD 168368;PD168368
• Molecular Weight: 554.65

Chemical and Physical Properties

• Refractive Index: n20D1.66 (Predicted)
• Boil Point(°C): ~819.7° C at 760 mmHg (Predicted)