Perfluoro(2-methyl-3-oxahexanoic) acid (HFPO-DA) - ≥97% , CAS No.13252-13-6

CAS: 13252-13-6 Cat. No.: P302398 Molecular Weight: 330.06 EC Number: 236-236-8 PubChem CID: 114481
AVAILABLE TO ORDER
GRADE & PURITY ≥97%
Synonyms
A806448 | Perfluoro(2-methyl-3-oxahexanoic)acid | (+/-)-PERFLUORO(2-PROPOXYPROPIONIC) ACID | PROPIONIC ACID, 2,3,3,3-TETRAFLUORO-2-(HEPTAFLUOROPROPOXY)- | OPFLCA_i n=3 (GenX) | perfluoro-2-propoxypropionic acid | 2,3,3,3-tetrafluoro-2-(1,1,2,2,3,3,3-hepta
Storage
Room temperature
Shipped In
Normal
 ·  off list, applied to all prices below.
Size
Status
Price
Qty
200mg
P302398-200mg
3
$9.90
1g
P302398-1g
3
$13.90
5g
P302398-5g
5
$29.90
25g
P302398-25g
1
$99.90
100g
P302398-100g
1
$289.90
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Why this grade

≥97% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Room temperature Ships Normal Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 16 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Specifications

Synonyms
A806448 | Perfluoro(2-methyl-3-oxahexanoic)acid | (+/-)-PERFLUORO(2-PROPOXYPROPIONIC) ACID | PROPIONIC ACID, 2, 3, 3, 3-TETRAFLUORO-2-(HEPTAFLUOROPROPOXY)- | OPFLCA_i n=3 (GenX) | perfluoro-2-propoxypropionic acid | 2, 3, 3, 3-tetrafluoro-2-(1, 1, 2, 2, 3, 3, 3-hepta
Specifications & Purity
≥97%
Storage
Room temperature
Shipped In
Normal
Purity
≥97%
Names and Identifiers
Pubchem Sid488187504
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488187504
Canonical SmilesC(=O)(C(C(F)(F)F)(OC(C(C(F)(F)F)(F)F)(F)F)F)O
IUPAC Name2,3,3,3-tetrafluoro-2-(1,1,2,2,3,3,3-heptafluoropropoxy)propanoic acid
InChIKeyCSEBNABAWMZWIF-UHFFFAOYSA-N
INCHI1S/C6HF11O3/c7-2(1(18)19,4(10,11)12)20-6(16,17)3(8,9)5(13,14)15/h(H,18,19)
Isomeric SMILES C(=O)(C(C(F)(F)F)(OC(C(C(F)(F)F)(F)F)(F)F)F)O
PubChem CID 114481
Molecular Weight 330.06

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
SubclassAlpha-halocarboxylic acids and derivatives
Intermediate Tree Nodes Not available
Direct ParentAlpha-halocarboxylic acids
Alternative Parents Monocarboxylic acids and derivatives  Carboxylic acids  Organofluorides  Organic oxides  Hydrocarbon derivatives  Carbonyl compounds  Alkyl fluorides  
Molecular FrameworkAliphatic acyclic compounds
Substituents Alpha-halocarboxylic acid - Monocarboxylic acid or derivatives - Carboxylic acid - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organofluoride - Organohalogen compound - Carbonyl group - Alkyl halide - Alkyl fluoride - Aliphatic acyclic compound
DescriptionThis compound belongs to the class of organic compounds known as alpha-halocarboxylic acids. These are carboxylic acids containing a halogen atom bonded to the alpha carbon atom.
External Descriptors Not available
3D Structure
Interactive Chemical Structure Model





Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

33 results found

Lot NumberCertificate TypeDateItem
E2609554Certificate of AnalysisApr 25, 2026 P302398
E2609553Certificate of AnalysisApr 25, 2026 P302398
E2609552Certificate of AnalysisApr 25, 2026 P302398
E2609551Certificate of AnalysisApr 25, 2026 P302398
E2609550Certificate of AnalysisApr 25, 2026 P302398
H2501496Certificate of AnalysisJul 03, 2025 P302398
H2501497Certificate of AnalysisJul 03, 2025 P302398
H2501498Certificate of AnalysisJul 03, 2025 P302398
H2501499Certificate of AnalysisJul 03, 2025 P302398
H2501500Certificate of AnalysisJul 03, 2025 P302398
A2627068Certificate of AnalysisJul 03, 2025 P302398
I2519070Certificate of AnalysisJul 03, 2025 P302398
K2520016Certificate of AnalysisJul 03, 2025 P302398
L2511078Certificate of AnalysisJul 03, 2025 P302398
I2215264Certificate of AnalysisJun 10, 2025 P302398
A2513328Certificate of AnalysisJul 23, 2024 P302398
F2520032Certificate of AnalysisJul 23, 2024 P302398
G2504024Certificate of AnalysisJul 23, 2024 P302398
H2401170Certificate of AnalysisJul 23, 2024 P302398
H2401171Certificate of AnalysisJul 23, 2024 P302398
H2401172Certificate of AnalysisJul 23, 2024 P302398
G2411149Certificate of AnalysisMay 06, 2024 P302398
A2402550Certificate of AnalysisNov 28, 2023 P302398
D2424047Certificate of AnalysisNov 28, 2023 P302398
A2402574Certificate of AnalysisNov 28, 2023 P302398
A2402560Certificate of AnalysisNov 28, 2023 P302398
A2402549Certificate of AnalysisNov 28, 2023 P302398
G2321168Certificate of AnalysisJun 30, 2022 P302398
I2215265Certificate of AnalysisJun 30, 2022 P302398
J2330027Certificate of AnalysisJun 30, 2022 P302398
G2222390Certificate of AnalysisMar 19, 2021 P302398
G2219224Certificate of AnalysisMar 19, 2021 P302398
E2107200Certificate of AnalysisMar 19, 2021 P302398

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Chemical and Physical Properties
Boil Point(°C)60°/10mm
Molecular Weight330.050 g/mol
XLogP33.600
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count14
Rotatable Bond Count4
Exact Mass329.975 Da
Monoisotopic Mass329.975 Da
Topological Polar Surface Area46.500 Ų
Heavy Atom Count20
Formal Charge0
Complexity383.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Citations of This Product
References
1. Shi-Ya Peng, Ya-Di Yang, Rong Tian, Naihao Lu.  (2024)  Critical new insights into the interactions of hexafluoropropylene oxide-dimer acid (GenX or HFPO-DA) with albumin at molecular and cellular levels.  Journal of Environmental Sciences,      [PMID:39181681] [10.1016/j.jes.2024.02.011]
2. Jinjing Huang, Kaixing Fu, Zhuoya Fang, Jinming Luo.  (2024)  Enhanced selective removal of PFAS at trace level using quaternized cellulose-functionalized polymer resin: Performance and mechanism.  WATER RESEARCH,      [PMID:39674139] [10.1016/j.watres.2024.122937]
3. Yang Wang, Hui Li, Ji Li, Lina Zhou, Chunkai Feng, Guangwei Liu, Jianzhi Wang, Chen Hou.  (2025)  Fluorophilic N, S self-doped porous carbon electrodes derived from biomass gelatin for electro-Fenton degradation of GenX.  Journal of Environmental Chemical Engineering,      [PMID:] [10.1016/j.jece.2025.115386]
4. Dengdiao Yao, Jian Shao, Dantong Jia, Weiling Sun.  (2024)  Immunotoxicity of legacy and alternative per- and polyfluoroalkyl substances on zebrafish larvae.  ENVIRONMENTAL POLLUTION,      [PMID:38977121] [10.1016/j.envpol.2024.124511]
5. Jianglin Hu, Jiayin Dai, Nan Sheng.  (2024)  Kynurenic Acid Plays a Protective Role in Hepatotoxicity Induced by HFPO-DA in Male Mice.  ENVIRONMENTAL SCIENCE & TECHNOLOGY,      [PMID:38228288] [10.1021/acs.est.3c08033]
6. Mei-Ling Le, Jia-Yu Xue, Li-Hai Wu, Xin-Yuan Zhao, Jing Ding, Yang-Yang Yuan, Yi-Qi Wan, Da-Lei Zhang.  (2025)  Hexafluoropropylene Oxide Homologues, the Novel Alternatives to PFOA, Induce Mitochondrial Dysfunction and Cytotoxicity in Leydig Cells through Disrupting SIRT1/PGC-1α Signaling Pathway.  TOXICOLOGY,      [PMID:40972997] [10.1016/j.tox.2025.154282]
7. Juan Li, Boqiang Li, Huimei Pan, Yiya Wei, Yang Yang, Nan Xu, Baiyang Chen, Madjid Mohseni, Ehsan Banayan Esfahani.  (2022)  Total organic fluorine (TOF) analysis by completely converting TOF into fluoride with vacuum ultraviolet.  JOURNAL OF HAZARDOUS MATERIALS,      [PMID:35236042] [10.1016/j.jhazmat.2022.128389]
8. Boxuan Yang, Yuxin Zeng, Tao Guo, Yuanzhong Lin, Lifeng Yin, Qingsong Hua.  (2025)  Electrocatalytic removal of Hexafluoropropylene oxide dimer acid (HFPO-DA) in water: “Buttering on both Sides”.  SEPARATION AND PURIFICATION TECHNOLOGY,      [PMID:] [10.1016/j.seppur.2025.133001]
9. Mei-Ling Le, Yi-Qi Wan, Jia-Yu Xue, Shi-Yi Deng, Bin-Hui Wang, Li-Hai Wu, Hou-Peng Wang, Yang-Yang Yuan, Xiao-Dong Kuang, Tao Luo, Da-Lei Zhang.  (2025)  HFPO homologues, the novel alternatives to PFOA, impair male reproduction in mice through inducing mitochondrial dysfunction.  ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,      [PMID:40460775] [10.1016/j.ecoenv.2025.118435]
10. Yuanyuan Wu, Weiqiang Sun, Xiyue Liu, Zhonghua Fan, Lin Cheng, Ying Yang, Li Wang, Hui Liu.  (2025)  PFOA and its substitutes disrupt fatty acid metabolism and impair erythrocyte homeostasis in zebrafish.  ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,      [PMID:40555089] [10.1016/j.ecoenv.2025.118546]
11. Shiqi Xiao, Yao Liu, Sheng Ding, Dianxiang Lu, Jin Yang, Xiangke Niu, Xin Qi, Jiawei Wei.  (2025)  GenX-loaded polystyrene microplastics exacerbate intestinal injury in mice via barrier impairment and microbial dysregulation.  Journal of Environmental Chemical Engineering,      [PMID:] [10.1016/j.jece.2025.119812]
12. Yangyang Yuan, Binhui Wang, Yuyu Fan, Meiling Le, Lihai Wu, Shiyi Deng, Jian Huang, Dalei Zhang.  (2025)  Comparative assessment of female reproductive toxicity from PFOA and its alternative GenX in mice and human granulosa cells.  TOXICOLOGY AND APPLIED PHARMACOLOGY,      [PMID:41232729] [10.1016/j.taap.2025.117639]
13. Qinyu Wang, Zhonghao Chen, Xinrui Li, Kemeng Wang, Ke Wang, Yinjuan Chen, Zhugen Yang, Yanyan Zhang, Lei Wang.  (2025)  Scalable and Sustainable Cellulose Xerogels for High-Capacity Enrichment of Per- and polyfluoroalkyl Substances.  WATER RESEARCH,      [PMID:41455428] [10.1016/j.watres.2025.125258]
14. Yuntao Qi, Qianyue Yin, Penghang Ni, Wansong Zong, Qigui Niu, Rutao Liu.  (2025)  Synergistic Effect of Nanoplastics and GenX on Human Serum Albumin: The Role of Protein Corona Formation and Co-Adsorption.  Toxics,  14  (1):   [PMID:41600561] [10.3390/toxics14010012]
15. Zhen Ren, Zimou Feng, Huaxing Liang, Zhiyang Zhu, Yi Yang, Xinglin Lu.  (2026)  In Situ Surfactant-Assisted Assembly for Efficient Removal of PFAS by Low-Pressure Ultrafiltration Membrane Process.  ENVIRONMENTAL SCIENCE & TECHNOLOGY,      [PMID:41489990] [10.1021/acs.est.5c13478]
16. Ding Hongran, Slack Maya, McClure Holly, Gu Wen, Gu Helene, Kappes Ferdinand, Schultz Thomas F., Somarelli Jason A., Tsigkou Anastasia.  (2026)  Exposure to PFOA and GenX elicits cell typespecific impacts on p53 and TGF-β signaling pathways.  MOLECULAR BIOLOGY REPORTS,  53  (1): (440).  [PMID:41758393] [10.1007/s11033-026-11571-x]
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