PF-03049423 , CAS No.402955-58-2

CAS: 402955-58-2 Cat. No.: P1443912 Molecular Weight: 468.5 PubChem CID: 24963293

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

PF-03049423 (Compound PF-5) is a potent and highly selective phosphodiesterase-5A inhibitor with an IC 50 of about 0.2 nM for rat and human platelet enzyme. PF-03049423 can be used for the research of acute ischaemic stroke.

Specifications

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Names and Identifiers

• Canonical Smiles: CCCOCCN1C2=CC(=NC=C2N=C(C1=O)N3CCN(CC3)CCO)C4=CN=C(C=C4)OC
• IUPAC Name: 3-[4-(2-hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-one
• InChIKey: MNLNAGRCHNMKKJ-UHFFFAOYSA-N
• INCHI: 1S/C24H32N6O4/c1-3-13-34-14-11-30-21-15-19(18-4-5-22(33-2)26-16-18)25-17-20(21)27-23(24(30)32)29-8-6-28(7-9-29)10-12-31/h4-5,15-17,31H,3,6-14H2,1-2H3
• Isomeric SMILES: CCCOCCN1C2=CC(=NC=C2N=C(C1=O)N3CCN(CC3)CCO)C4=CN=C(C=C4)OC
• PubChem CID: 24963293
• Molecular Weight: 468.5

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Class Pyridines and derivatives
      • Subclass Bipyridines and oligopyridines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Class: Pyridines and derivatives
• Subclass: Bipyridines and oligopyridines
• Intermediate Tree Nodes: Not available
• Direct Parent: Bipyridines and oligopyridines
• Alternative Parents: N-arylpiperazines Pyridopyrazines Dialkylarylamines Alkyl aryl ethers N-alkylpiperazines Aminopyrazines Imidolactams Heteroaromatic compounds Trialkylamines 1,2-aminoalcohols Lactams Azacyclic compounds Dialkyl ethers Hydrocarbon derivatives Primary alcohols Organic oxides
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Bipyridine - N-arylpiperazine - Pyridopyrazine - Dialkylarylamine - Alkyl aryl ether - N-alkylpiperazine - Aminopyrazine - Imidolactam - Pyrazine - Piperazine - 1,4-diazinane - Heteroaromatic compound - 1,2-aminoalcohol - Tertiary aliphatic amine - Tertiary amine - Lactam - Alkanolamine - Azacycle - Dialkyl ether - Ether - Organic oxide - Organonitrogen compound - Organooxygen compound - Organic nitrogen compound - Primary alcohol - Amine - Organic oxygen compound - Hydrocarbon derivative - Alcohol - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as bipyridines and oligopyridines. These are organic compounds containing two pyridine rings linked to each other.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y