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· · COA & SDS available for every product · Same-day shipping on in-stock items PF-04929113 (SNX-5422) - ≥98% , Heat shock protein HSP90 inhibitor, CAS No.908115-27-5, Heat shock protein HSP90 inhibitor
Synonyms
(1r,4r)-4-((2-carbamoyl-5-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenyl)amino)cyclohexyl glycinate | BBL027742 | ETHYL CYANOACETATE [HSDB] | EX-A2343 | PF-04929113 (SNX-5422) | Acetal resin | Glycine Trans-4-((2-(aminoc
Shipped In
Ice chest + Ice pads
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Why this grade ≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview PF-04929113 (SNX-5422) is a potent and selective HSP90 inhibitor with Kd of 41 nM and induces Her-2 degradation with IC50 of 37 nM. Phase 1/2.
Specifications Synonyms
(1r, 4r)-4-((2-carbamoyl-5-(6, 6-dimethyl-4-oxo-3-(trifluoromethyl)-4, 5, 6, 7-tetrahydro-1H-indazol-1-yl)phenyl)amino)cyclohexyl glycinate | BBL027742 | ETHYL CYANOACETATE [HSDB] | EX-A2343 | PF-04929113 (SNX-5422) | Acetal resin | Glycine Trans-4-((2-(aminoc
Specifications & Purity
≥98%
Biochemical and Physiological Mechanisms
PF-04929113 (SNX-5422) is a potent and selective Hsp90 inhibitor (Kd of 41 nM). PF-04929113 also inhibits Her-2 degradation (IC50 of 37 nM). PF-04929113 is a small-molecule Hsp90 inhibitor based on the 6, 7-dihydro-indazol-4-one scaffold. PF-04929113 exhib
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Mechanism of action
Heat shock protein HSP90 inhibitor
Note
Toxic, refer to SDS for further information Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Properties Names and Identifiers Pubchem Sid 504770308 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504770308 Canonical Smiles CC1(CC2=C(C(=O)C1)C(=NN2C3=CC(=C(C=C3)C(=O)N)NC4CCC(CC4)OC(=O)CN)C(F)(F)F)C IUPAC Name [4-[2-carbamoyl-5-[6,6-dimethyl-4-oxo-3-(trifluoromethyl)-5,7-dihydroindazol-1-yl]anilino]cyclohexyl] 2-aminoacetate InChIKey AVDSOVJPJZVBTC-UHFFFAOYSA-N INCHI 1S/C25H30F3N5O4/c1-24(2)10-18-21(19(34)11-24)22(25(26,27)28)32-33(18)14-5-8-16(23(30)36)17(9-14)31-13-3-6-15(7-4-13)37-20(35)12-29/h5,8-9,13,15,31H,3-4,6-7,10-12,29H2,1-2H3,(H2,30,36) Isomeric SMILES CC1(CC2=C(C(=O)C1)C(=NN2C3=CC(=C(C=C3)C(=O)N)NC4CCC(CC4)OC(=O)CN)C(F)(F)F)C Molecular Weight 521.54 Reaxy-Rn 24865311 Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24865311&ln=
Documentation 📋 Safety Data Sheet (SDS) Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS → ✅ Certificate of Analysis (COA) Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA → 📊 Datasheet Quick-reference summary of product specifications and applications.
View datasheet → 🔬 Specification Sheet Full quality attributes and acceptance criteria for this grade.
View spec sheet →
Advanced Data Taxonomic Classification Kingdom Organic compounds Superclass Organic acids and derivatives Class Carboxylic acids and derivatives Subclass Amino acids, peptides, and analogues Intermediate Tree Nodes Amino acids and derivatives - Alpha amino acids and derivatives Direct Parent Alpha amino acid esters Alternative Parents Phenylpyrazoles 2-aminobenzamides Anthranilamides Phenylalkylamines Aniline and substituted anilines Aryl alkyl ketones Benzoyl derivatives Secondary alkylarylamines Cyclohexylamines Vinylogous amides Heteroaromatic compounds Primary carboxylic acid amides Carboxylic acid esters Monocarboxylic acids and derivatives Azacyclic compounds Monoalkylamines Organofluorides Organic oxides Alkyl fluorides Hydrocarbon derivatives Molecular Framework Aromatic heteropolycyclic compounds Substituents Alpha-amino acid ester - Phenylpyrazole - Anthranilamide - Aminobenzamide - Aminobenzoic acid or derivatives - 2-aminobenzamide - Benzoic acid or derivatives - Benzamide - Benzoyl - Aryl ketone - Aryl alkyl ketone - Aniline or substituted anilines - Phenylalkylamine - Cyclohexylamine - Secondary aliphatic/aromatic amine - Benzenoid - Monocyclic benzene moiety - Heteroaromatic compound - Pyrazole - Vinylogous amide - Azole - Primary carboxylic acid amide - Ketone - Carboxylic acid ester - Carboxamide group - Azacycle - Organoheterocyclic compound - Secondary amine - Monocarboxylic acid or derivatives - Organonitrogen compound - Organooxygen compound - Carbonyl group - Primary amine - Organic nitrogen compound - Alkyl halide - Alkyl fluoride - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Organofluoride - Organohalogen compound - Primary aliphatic amine - Amine - Aromatic heteropolycyclic compound Description This compound belongs to the class of organic compounds known as alpha amino acid esters. These are ester derivatives of alpha amino acids. External Descriptors Not available Data sources 1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solubility DMSO 104 mg/mL Water <1 mg/mL Ethanol 5 mg/mL Molecular Weight 521.500 g/mol XLogP3 3.500 Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 10 Rotatable Bond Count 7 Exact Mass 521.225 Da Monoisotopic Mass 521.225 Da Topological Polar Surface Area 142.000 Ų Heavy Atom Count 37 Formal Charge 0 Complexity 877.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 0 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 1
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