PFK15 - Moligand™, 10mM in DMSO , Inhibitor of 6-phosphofructo-2-kinase/fructose-2;6-biphosphatase 3, CAS No.4382-63-2, Inhibitor of 6-phosphofructo-2-kinase/fructose-2;6-biphosphatase 3

CAS: 4382-63-2 Cat. No.: P407887 Molecular Weight: 260.29 EC Number: 809-326-5 PubChem CID: 25142799

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

PFK-015 | 2-​Propen-​1-​one, 1-​(4-​pyridinyl)​-​3-​(2-​quinolinyl)​-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

PFK15 PFK15 (PFK-015) is a potent and selective 6-phosphofructo-2-kinase (PFKFB3) inhibitor with IC50 of 207 nM.
In vitro

PFK15 produces potent growth inhibition in a series of cancer cells. In Jurkat T-cell leukemia cells and H522 lung adenocarcinoma cells, PFK15 also reduces F26BP, glucose uptake, and intracellular ATP level.

In vivo

In vivo, PFK15 has adequate pharmacokinetic properties. PFK15 (25 mg/kg i.p.) suppresses the growth, metastatic spread, and glucose metabolism of LLC tumors in syngeneic mice. In three human xenograft models of cancer in athymic mice, PFK15 also yields antitumor effects that are comparable to approved chemotherapeutic agents.
Cell Data

cell lines：

Concentrations：~30 μM

Incubation Time：48 hours

Powder Purity:≥99%

Specifications

Synonyms

PFK-015 | 2-​Propen-​1-​one, 1-​(4-​pyridinyl)​-​3-​(2-​quinolinyl)​-

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

PFK15 (PFK-015) is a potent and selective 6-phosphofructo-2-kinase (PFKFB3) inhibitor with IC50 of 207 nM.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

INHIBITOR

Mechanism of action

Inhibitor of 6-phosphofructo-2-kinase/fructose-2;6-biphosphatase 3

Names and Identifiers

• Isomeric SMILES: C1=CC=C2C(=C1)C=CC(=N2)/C=C/C(=O)C3=CC=NC=C3
• WGK Germany: 3
• Alternate CAS: 4382-63-2
• PubChem CID: 25142799
• MeSH Entry Terms: 1-(4-pyridinyl)-3-(2-quinolinyl)-2-propen-1-one;PFK15
• Molecular Weight: 260.29

Associated Targets(Human)

PFKFB3 Tchem 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (1 Activities)

Discover Target: PFKFB3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)