PIP4K-IN-a131 - ≥98% , CAS No.2055405-95-1

CAS: 2055405-95-1 Cat. No.: P647564 Molecular Weight: 295.34 PubChem CID: 124124841

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PIP4K-IN-a131 - ≥98% CAS No(2055405-95-1) by Aladdin Scientific

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AVAILABLE TO ORDER

GRADE & PURITY ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview Specifications Names and Identifiers Documentation Advanced Data 3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solution Calculators Reviews

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Why this grade

≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

PIP4K-IN-a131 is PIP4K lipid kinases inhibitor, with IC 50 s of 1.9 µM and 0.6 µM for purified PIP4K2A and PIP4Ks, respectively. PIP4K-IN-a131 exhibits cancer-selective lethality via dual blockade of the lipid kinase PIP4Ks and mitotic pathways

In Vitro

PIP4K-IN-a131 (0-100 μM; 72 hours) is a potent antiproliferative agent with a clear selectivity toward cancer cells killing. PIP4K-IN-a131 eliminates cancer cells via a dual-inhibitory mechanism. PIP4K-IN-a131 causes inhibition of the PI3K/Akt/mTOR pathway only in normal BJ cells, but not in transformed counterparts. Inhibition of PIP4Ks by PIP4K-IN-a131 arrests normal cells at the G1/S phase of the cell cycle by suppressing the PI3K/Akt/mTOR signaling pathway via transcriptional upregulation of PIK3IP1. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation AssayCell Line: Normal and transformed BJ cells Concentration: 0-100 μM (MTT assay) Incubation Time: 72 hours Result: Selective killed cancer cells. RT-PCRCell Line: BJ cells Concentration: 5 µM Incubation Time: 24 hours Result: Induced the upregulation of PIK3IP1 mRNA levels.

Form:Solid

IC50& Target:IC50: 1.9 µM (PIP4K2A), 0.6 µM (PIP4Ks)

Specifications

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

PIP4K-IN-a131 is PIP4K lipid kinases inhibitor, with IC 50 s of 1.9u2009µM and 0.6u2009µM for purified PIP4K2A and PIP4Ks, respectively. PIP4K-IN-a131 exhibits cancer-selective lethality via dual blockade of the lipid kinase PIP4Ks and mitotic pathways [1

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥98%

Names and Identifiers

Canonical Smiles	C1=CC=C2C(=C1)C(=CN2)C(=CC3=CC=CC4=C3C=CN=C4)C#N
IUPAC Name	(Z)-2-(1H-indol-3-yl)-3-isoquinolin-5-ylprop-2-enenitrile
InChIKey	GWWKEWLUVHLNEX-MHWRWJLKSA-N
INCHI	1S/C20H13N3/c21-11-16(19-13-23-20-7-2-1-6-18(19)20)10-14-4-3-5-15-12-22-9-8-17(14)15/h1-10,12-13,23H/b16-10+
Isomeric SMILES	C1=CC=C2C(=C1)C(=CN2)/C(=C/C3=CC=CC4=C3C=CN=C4)/C#N
PubChem CID	124124841
Molecular Weight	295.34

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

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✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

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📊 Datasheet

Quick-reference summary of product specifications and applications.

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🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

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Advanced Data

3D Structure

Associated Targets(Human)

AGS (1999 Activities)