Poly-D-lysine hydrobromide is a positively charged synthetic polyamino acid having one HBr per lysine unit. It is a crystalline solid soluble in water. Poly-D-lysine hydrobromide is widely used as a coating to enhance cell attachment and adhesion to both plasticware and glass surfaces. This polycation is resistant to enzymatic degradation and has been used to culture a wide variety of cell types. Other applications for poly-D-lysine include the conjugation to active molecules for improved activities, the layer-by-layer deposition techniques, and the complexation with nucleic acids for gene expression.For cell culture applications, poly-D-lysine hydrobromide with a molecular weight greater than 30,000 Da is recommended. The poly-D-lysine hydrobromide (MW=52,000 Da) is easier to use because it is less viscous in solution, however the poly-D-lysine hydrobromide with an higher molecular weight (MW=84,000 Da) has more attachement sites per polymer chain available to the cells. Both poly-D-lysine hydrobromide and poly-L-lysine hydrobromide can be used as a coating substrate, however certain cells digest poly-L-lysine hydrobromide. In this case, poly-D-lysine, as the attachment factor, is necessary to prevent cell disruption by excessive uptake of L-lysine.Our poly-D-lysine hydrobromide has been purified by dialysis, sterile-filtered on 0.2um, lyophilized, and stored under Ar.
Product Specification Reference Number：
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| Canonical Smiles | C(CCN)CC(C(=O)O)N.Br |
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| IUPAC Name | (2R)-2,6-diaminohexanoic acid;hydrobromide |
| InChIKey | MEXAGTSTSPYCEP-NUBCRITNSA-N |
| INCHI | 1S/C6H14N2O2.BrH/c7-4-2-1-3-5(8)6(9)10;/h5H,1-4,7-8H2,(H,9,10);1H/t5-;/m1./s1 |
| Isomeric SMILES | C(CCN)C[C@H](C(=O)O)N.Br |
| PubChem CID | 87493163 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
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View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organic acids and derivatives |
| Class | Carboxylic acids and derivatives |
| Subclass | Amino acids, peptides, and analogues |
| Intermediate Tree Nodes | Amino acids and derivatives - Alpha amino acids and derivatives - Alpha amino acids |
| Direct Parent | D-alpha-amino acids |
| Alternative Parents | Medium-chain fatty acids Amino fatty acids Amino acids Monocarboxylic acids and derivatives Carboxylic acids Organic oxides Monoalkylamines Hydrocarbon derivatives Hydrobromides Carbonyl compounds |
| Molecular Framework | Aliphatic acyclic compounds |
| Substituents | D-alpha-amino acid - Medium-chain fatty acid - Amino fatty acid - Fatty acid - Fatty acyl - Amino acid - Carboxylic acid - Monocarboxylic acid or derivatives - Amine - Hydrobromide - Hydrocarbon derivative - Primary amine - Organooxygen compound - Organonitrogen compound - Organic oxide - Primary aliphatic amine - Organic oxygen compound - Carbonyl group - Organic nitrogen compound - Aliphatic acyclic compound |
| Description | This compound belongs to the class of organic compounds known as d-alpha-amino acids. These are alpha amino acids which have the D-configuration of the alpha-carbon atom. |
| External Descriptors | Not available |
| Sensitivity | Light sensitive |
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| Flash Point(°F) | Not applicable |
| Flash Point(°C) | Not applicable |
| 1. Hai-Mu Ye, Shu-Fang Yao. (2017) Supernucleating Role of Poly(ω-pentadecalactone) during the Crystallization of Poly(ε-caprolactone) Composites. INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, [PMID:] [10.1021/acs.iecr.7b03322] |
