Pomalidomide-PEG₄-Azide - ≥95% , CAS No.2271036-47-4

CAS: 2271036-47-4 Cat. No.: P463556 Molecular Weight: 518.52 PubChem CID: 145714646

GRADE & PURITY ≥95%

Synonyms

14-Azido-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-3,6,9,12-tetraoxatetradecanamide, Crosslinker-E3 ligase ligand conjugate, Protein degrader building block for PROTAC research, Pomalidomide conjugate, Template for synthesis of targe

Storage

Protected from light,Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Application

230

Overview

Description

Protein degrader builiding block Pomalidomide-PEG4-Azide enables the synthesis of molecules fortargeted protein degradation andPROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation.When used with other protein degrader building blockswith a pendant azide, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Specifications

Synonyms

14-Azido-N-(2-(2, 6-dioxopiperidin-3-yl)-1, 3-dioxoisoindolin-4-yl)-3, 6, 9, 12-tetraoxatetradecanamide, Crosslinker-E3 ligase ligand conjugate, Protein degrader building block for PROTAC research, Pomalidomide conjugate, Template for synthesis of targe

Specifications & Purity

≥95%

Storage

Protected from light, Store at -20°C, Argon charged

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥95%

Names and Identifiers

• Pubchem Sid: 504773593
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504773593
• Canonical Smiles: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NCCOCCOCCOCCOCCN=[N+]=[N-]
• PubChem CID: 145714646
• Molecular Weight: 518.52

Chemical and Physical Properties

• Sensitivity: Light sensitive
• Molecular Weight: 518.500 g/mol
• XLogP3: 1.200
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 11
• Rotatable Bond Count: 17
• Exact Mass: 518.213 Da
• Monoisotopic Mass: 518.213 Da
• Topological Polar Surface Area: 147.000 Ų
• Heavy Atom Count: 37
• Formal Charge: 0
• Complexity: 851.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1