10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 19 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
Prednisolone (NSC-9900) Prednisolone (NSC-9900) is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.
In vitro
Prednisolone (50 mg/kg, im) given 15 min before LPS-attenuated production of NO2- and NO3- by neutrophils and suppresses LPS-stimulated mRNA for NOS II in rat neutrophils. Prednisolone reduces joint swelling through a mechanism associated with a reduction in IL-1beta and IL-6 protein and mRNA expression levels in SCW-induced arthritis rats. Prednisolone\'s anti-inflammatory effects can be mediated by reducing cellular adhesion molecule (CAM) expression. Prednisolone (0.75 mg/kg) reduces macrophages (-59%, -57%), CD4(+) T-cells (-50%, -60%), CD8(+) T-cells (-58%, -48%), and eosinophils (-36%, -25%) in quadriceps and soleus muscles, respectively. Prednisolone-treated mice also exhibits decreased vascular P-selectin (-82%) and ICAM-1 (-52%) expression and fewer L-selectin (-79%) and ICAM-1 (-57%) expressing mononuclear cells in quadriceps. Prednisolone reduces sarcolemmal damage and degeneration as well in Dystrophin-deficient, mdx mice.
In vivo
Prednisolone (5 mg/kg) causes alterations in diaphragmatic contractile properties and histological changes without fiber atrophy in rats. Prednisolone results in an increased number of diaphragmatic bundles in rats. Prednisolone induces a significant decline of PL-pO2, while CoBF, CMs, CAPs, and ABRs revealed no change in guinea pigs.
Cell Data
cell lines：
Concentrations：
Incubation Time：
Powder Purity:≥98%
| ALogP | 1.6 |
|---|
| Isomeric SMILES | C[C@]12C[C@@H]([C@H]3[C@H]([C@@H]1CC[C@@]2(C(=O)CO)O)CCC4=CC(=O)C=C[C@]34C)O |
|---|---|
| Molecular Weight | 360.44 |
| Reaxy-Rn | 2339782 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2339782&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| Flash Point(°C) | 2℃ |
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| Boil Point(°C) | 412.46°C (rough estimate) |
| Melt Point(°C) | 240 °C (dec.)(lit.) |
| 1. Jiadi Shen, Chenyu Weng, Shuxian Zhu, Wanjing Chen, Xuening Xiong, Xin Wei. (2025) Protein Phosphatases 2A Affects Drug Resistance of Candida albicans Biofilm Via ATG Protein Phosphorylation Induction. INTERNATIONAL DENTAL JOURNAL, [PMID:40885126] [10.1016/j.identj.2025.103873] |
| 2. Jiadi Shen, Yuzhi Li, Haochen Miao. (2025) The PP2A Catalytic Subunit PPH21 Regulates Biofilm Formation and Drug Resistance of Candida albicans. Microorganisms, 13 (9): (2093). [PMID:41011426] [10.3390/microorganisms13092093] |
| 3. Guozheng Zhao. (2023) Multi-Residue Detection of Eight Glucocorticoids by Nano-Au/Fluticasone Propionate Electrochemical Immunosensor. MOLECULES, 28 (18): (6619). [PMID:37764395] [10.3390/molecules28186619] |
| 4. Yuan Liang, Zhuolin Li, Jie Zhang, Tiezhu Li, Chengyu Lv. (2023) Comparison of the Glucocorticoid Receptor Binding and Agonist Activities of Typical Glucocorticoids: Insights into Their Endocrine Disrupting Effects. CHEMISTRY & BIODIVERSITY, [PMID:38129310] [10.1002/cbdv.202301525] |
| 5. Yunjia Wang, Zhongjing Jiang, Linhua Deng, Gengming Zhang, Xia Xu, Emmanuel Alonge, Hongqi Zhang, Chaofeng Guo. (2023) Dendrobium offificinale polysaccharides prevents glucocorticoids-induced osteoporosis by destabilizing KEAP1-NRF2 interaction. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, [PMID:37652317] [10.1016/j.ijbiomac.2023.126600] |
| 6. Haoyu Long, Yanhao Jiang, Yanjuan Liu, Yuefei Zhang, Wei Chen, Sheng Tang. (2023) Chromatographic separation performance of silica microspheres surface-modified with triazine-containing imine-linked covalent organic frameworks. TALANTA, [PMID:37126925] [10.1016/j.talanta.2023.124589] |
| 7. Si-xuan Zhou, Xiao-tong Lin, Jie Wang, Hai-xiang Wang, Gui-tang Chen. (2023) Novel hydrocortisone magnetic molecularly imprinted polymers: Preparation, characterization, and application. FOOD CHEMISTRY, [PMID:37116443] [10.1016/j.foodchem.2023.136196] |
| 8. Zhehuan Wang, Huiru Zhang, Caihong Qi, Hui Guo, Xiangyue Jiao, Jia Yan, Yifei Wang, Qiangsheng Li, Mingming Zhao, Xinhao Guo, Baoluo Wan, Xiaotian Li. (2023) Ursolic acid ameliorates DNCB-induced atopic dermatitis-like symptoms in mice by regulating TLR4/NF-κB and Nrf2/HO-1 signaling pathways. INTERNATIONAL IMMUNOPHARMACOLOGY, [PMID:36996741] [10.1016/j.intimp.2023.110079] |
| 9. Cao Xia, He Qing, Adu-Frimpong Michael, Shen Xinyi, Rong Wanjing, Li Xiaoxiao, Zhang Jian, Xia Xiaoli, Shi Feng, Ji Hao, Toreniyazov Elmurat, Wang Qilong, Yu Jiangnan, Xu Ximing. (2022) Preparation of Pinocembrin-Loaded F127/MPEG-PDLLA Polymer Micelles and Anti-Osteoporotic Activity. AAPS PHARMSCITECH, 23 (7): (1-13). [PMID:36207561] [10.1208/s12249-022-02427-1] |
| 10. Yi Tao, Lin Chen, Meiling Pan, Fei Zhu, Jizhong Yan. (2021) Tracing anti-osteoporosis components from raw and salt-processed semen of Cuscuta chinensis by employing a biochemometrics strategy that integrates ultrasonic-assisted extraction, quantitation, efficacy assessment in zebrafish, and grey relationship analysis. JOURNAL OF SEPARATION SCIENCE, 44 (17): (3229-3236). [PMID:34240804] [10.1002/jssc.202100272] |
| 11. Ying-Qi Li, Yi Chen, Jia-Yi Fang, Si-Qi Jiang, Ping Li, Fei Li. (2020) Integrated network pharmacology and zebrafish model to investigate dual-effects components of Cistanche tubulosa for treating both Osteoporosis and Alzheimer's Disease. JOURNAL OF ETHNOPHARMACOLOGY, [PMID:32173426] [10.1016/j.jep.2020.112764] |
| 12. Shoubao Wang, Yao Xiong, Yinmin Wang, Jingting Chen, Jun Yang, Binbin Sun. (2020) Evaluation of PLGA microspheres with triple regimen on long-term survival of vascularized composite allograft – an experimental study. TRANSPLANT INTERNATIONAL, 33 (4): (450-461). [PMID:31930539] [10.1111/tri.13574] |
| 13. Jia-Bi Lin, Hao Wu, Yu-Ling Liu, Pang-Chui Shaw, Pei-Bo Li. (2018) Transcriptome analysis reveals functional roles of nacreous protein N16 in prednisolone-induced osteoporotic zebrafish. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, [PMID:30219513] [10.1016/j.ijbiomac.2018.09.055] |
| 14. Guozheng Zhao. (2024) Detection of six glucocorticoids using a nanogold-glucocorticoid receptor-based biosensor. CHEMICAL PHYSICS LETTERS, [PMID:] [10.1016/j.cplett.2024.141611] |
| 15. Guowen Li, Mengjia Chao, Chun Zhang, Hang Gao, Xiuping Li, Hongxin Ren, Xinlin Wei, Chifang Peng, Wei Ma, Zhouping Wang. (2025) Supraparticle Nanoarchitectonics with Bright Gold Nanoclusters Induced by Host–Guest Recognition for Volatile Amine and Meat Freshness Detection. ACS Applied Nano Materials, [PMID:] [10.1021/acsanm.5c00366] |
| 16. Rong Huang, Wenyu Zhang, Yueqi Hu, Junjie Xu, Zhihui Dong, Jikai Liu, Li Zhou. (2025) Houttuynia cordata polysaccharides ameliorate atopic dermatitis in mice through modulation of skin immune barrier and lipid metabolism. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, [PMID:40393586] [10.1016/j.ijbiomac.2025.144264] |
| 17. Yuan-Yuan Yang, Bao-Zhu Jia, Zhen-Lin Xu, Yi-Xian Liu, Lin Luo. (2025) Magnetic Particle-Based Automated Chemiluminescence Immunoassay for the Determination of Hydrocortisone Residues in Milk. Foods, 14 (12): (2105). [PMID:40565714] [10.3390/foods14122105] |
| 18. Xiaolu Chen, Muyao Cui, Jiaqi Li, Qi Chen, Linzhen Chen, Zhuo Yang, Qiqi Fan, Yuhan Sheng, Ruichao Lin, Zhiqiang Ma, Chongjun Zhao. (2025) Evaluation of the safety and efficacy of Sophorae Flavescentis Radix extract in the treatment of inflammatory bowel disease based on zebrafish models. Frontiers in Immunology, [PMID:41394814] [10.3389/fimmu.2025.1722777] |
| 19. Jiang Cheng, Naihui Hou, Tengda Wang, Zhenyun Zhao\u003Csup\u003E*\u003C\u002Fsup\u003E, Wei Chen\u003Csup\u003E*\u003C\u002Fsup\u003E. (2026) Dual-function core-shell nanocube probes enabling continuous production of cortisol-sensing yarns via conjugate electrospinning. Soft Science, 6 (2): (N). [PMID:] [10.20517/ss.2025.123] |
