Prednisone (NSC-10023) - Moligand™, 10mM in DMSO , Glucocorticoid receptor agonist, CAS No.53-03-2, Glucocorticoid receptor agonist

CAS: 53-03-2 Cat. No.: P407744 Molecular Weight: 358.43 Beilstein Registry Number: 2065301 EC Number: 200-160-3

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

Adasone | 17,​21-​dihydroxy-pregna-​1,​4-​diene-​3,​11,​20-​trione

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Prednisone (NSC-10023) Prednisone (NSC-10023, Adasone) is a synthetic corticosteroid agent that is particularly effective as an immunosuppressant compound.
In vitro

Prednisone blocks Peripheral blood lymphocytes (PBL) growth in the G1 phase of cell cycle and inhibits both IL-2 receptor (IL-2R) expression and IL-2 secretion in activated human peripheral blood T lymphocytes. Prednisone increases apoptosis in PHA-activated human PBL, and the apoptotic effect of Prednisone is stronger on CD8(+) than on CD4(+) T lymphocytes.

In vivo

Prednisone-treated rats show a significant delay of 20% in learning and memory retention in rats as compared with controls. Prednisone results in reduced weight gain, unchanged alter uterine weight, lowered serum magnesium (Mg), unchange serum calcium (Ca), phosphate (P), 25-hydroxyvitamin D (25OHD), or 1,25-dihydroxyvitamin D [1,25(OH)2D], striking increased in calcified cartilage, reduced cross-sectional area and cortical area, unchange medullary area of the tibial diaphysis, lowered periosteal and endocortical bone formation and apposition rates, increased mean cancellous bone area and cancellous bone perimeter of the tibial metaphysis in both sham-operated and ovariectomized rats. Prednisone-treated rabbit shows a 30% reduction in percent stenosis, a 35% decrease in neointimal area, and a 66% decrement in neointimal thickness. Prednisone treatment significantly reduces the level of TGF-beta1 and HYP in diaphragm from mdx mice to values similar to control mice, but results in a higher level of the HP cross-link compared with untreated mdx mice.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥98%

Specifications

Synonyms

Adasone | 17, ​21-​dihydroxy-pregna-​1, ​4-​diene-​3, ​11, ​20-​trione

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Prednisone (NSC-10023, Adasone) is a synthetic corticosteroid agent that is particularly effective as an immunosuppressant compound.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

AGONIST

Mechanism of action

Glucocorticoid receptor agonist

Product Properties

• ALogP: 1.5

Names and Identifiers

• Isomeric SMILES: C[C@]12CC(=O)[C@H]3[C@H]([C@@H]1CC[C@@]2(C(=O)CO)O)CCC4=CC(=O)C=C[C@]34C
• WGK Germany: 3
• RTECS: TU4154100
• Alternate CAS: 53-03-2
• NSC Number: 10023
• MeSH Entry Terms: Acsis, Prednison;Apo-Prednisone;Cortan;Cortancyl;Cutason;Dacortin;Decortin;Decortisyl;Dehydrocortisone;delta-Cortisone;Deltasone;Encorton;Encortone;Enkortolon;Kortancyl;Liquid Pred;Meticorten;Orasone;Panafcort;Panasol;Predni Tablinen;Prednidib;Predniment
• Molecular Weight: 358.43
• Beilstein: 2065301
• Reaxy-Rn: 29841917
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=29841917&ln=

Associated Targets(Human)

NR3C1 Tclin Glucocorticoid receptor (2 Activities)

Discover Target: NR3C1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Melt Point(°C): 233-235°C

References

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