Probucol - Moligand™, 10mM in DMSO , ATP-binding cassette sub-family A member 1 inhibitor, CAS No.23288-49-5, ATP-binding cassette sub-family A member 1 inhibitor

CAS: 23288-49-5 Cat. No.: P408795 Molecular Weight: 516.84 EC Number: 245-560-9

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

DH-581 | 4,​4'-​[(1-​methylethylidene)​bis(thio)​]​bis[2,​6-​bis(1,​1-​dimethylethyl)​-phenol

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Probucol Probucol (DH-581) is an anti-hyperlipidemic drug by lowering the level of cholesterol in the bloodstream by increasing the rate of LDL catabolism.
In vitro

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

DH-581 | 4, ​4'-​[(1-​methylethylidene)​bis(thio)​]​bis[2, ​6-​bis(1, ​1-​dimethylethyl)​-phenol

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Probucol (DH-581) is an anti-hyperlipidemic drug by lowering the level of cholesterol in the bloodstream by increasing the rate of LDL catabolism.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

INHIBITOR

Mechanism of action

ATP-binding cassette sub-family A member 1 inhibitor

Product Properties

• ALogP: 11.3

Names and Identifiers

• Isomeric SMILES: CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)SC(C)(C)SC2=CC(=C(C(=C2)C(C)(C)C)O)C(C)(C)C
• RTECS: AL3705000
• Molecular Weight: 516.84
• Reaxy-Rn: 2026253
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2026253&ln=

Associated Targets(Human)

HPN Tchem Serine protease hepsin (1 Activities)

Discover Target: HPN

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro
• Melt Point(°C): 128°C

References

1. Xiaowei Wang, Wenjun Zhang, Sheng Zeng, Liudi Wang, Bin Wang.  (2023)  Collagenase Type I and Probucol-Loaded Nanoparticles Penetrate the Extracellular Matrix to Target Hepatic Stellate Cells for Hepatic Fibrosis Therapy.  Acta Biomaterialia,      [PMID:38141933] [10.1016/j.actbio.2023.12.027]

2. Hongyan Lu, Guangzhao Yang, Fu Ran, Tianbin Gao, Changshan Sun, Qinfu Zhao, Siling Wang.  (2019)  Polymer-functionalized mesoporous carbon nanoparticles on overcoming multiple barriers and improving oral bioavailability of Probucol.  CARBOHYDRATE POLYMERS,      [PMID:31826471] [10.1016/j.carbpol.2019.115508]