PTD10 is a highly potent PROTAC BTK degrader ( DC 50 : 0.5 nM, K D : 2.28 nM). PTD10 degrades BTK in Ramos and JeKo-1 cells with DC 50 s of 0.5 and 0.6 nM respectively. PTD10 inhibits cell growth, and induces cell apoptosis via activation of the caspase-dependent pathway and mitochondrial pathway. PTD10 can be used for research of B-cell dysregulation.
Specifications
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Action Type
DEGRADER
Names and Identifiers
Molecular Weight
922.00
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
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