Remdesivir (GS-5734) - Moligand™, 10mM in DMSO , Replicase polyprotein 1ab inhibitor, CAS No.1809249-37-3, Replicase polyprotein 1ab inhibitor

CAS: 1809249-37-3 Cat. No.: R408405 Molecular Weight: 602.58 EC Number: 852-825-8 PubChem CID: 121304016

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

L-Alanine, N-[(S)-hydroxyphenoxyphosphinyl]-, 2-ethylbutyl ester, 6-ester with 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-D-altrononitrile

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Remdesivir (GS-5734), a monophosphoramidate prodrug of an adenosine analog, is an investigational broad-spectrumantiviralagent with in vitro activity against multiple RNA viruses, including Ebola and CoV.
In vitro

GS-5734 exhibits antiviral activity against multiple variants of EBOV in cell-based assays(EC50=0.06-0.14 μM) and broad-spectrum antiviral activity in vitro against other pathogenic RNA viruses. GS-5734 acts as a broad-spectrum therapeutic to protect against CoVs with EC50 of 0.03 μM for murine hepatitis virus in delayed brain tumor cells and 0.074 μM for SARS-CoV and MERS-CoV in HAE cells.

In vivo

Regardless of the time of initiation, GS-5734 treatment confers improved survival when administered by 3 mg/kg GS-5734. All animals in which 10 mg/kg GS-5734 treatments is initiated 3 days after virus exposure survive to the end of the in-life phase. However, the antiviral effects are consistently greater in animals administered repeated 10 mg/kg GS-5734 doses. The 10 mg/kg D3 (administered beginning 3 days after virus exposure) GS-5734 regimen is associated with amelioration of EVD-related clinical disease signs and markers of coagulopathy and end organ pathophysiology.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

L-Alanine, N-[(S)-hydroxyphenoxyphosphinyl]-, 2-ethylbutyl ester, 6-ester with 2-C-(4-aminopyrrolo[2, 1-f][1, 2, 4]triazin-7-yl)-2, 5-anhydro-D-altrononitrile

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Remdesivir (GS-5734), a monophosphoramidate prodrug of an adenosine analog, is an investigational broad-spectrum antiviral agent with in vitro activity against multiple RNA viruses, including Ebola and CoV.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

INHIBITOR

Mechanism of action

Replicase polyprotein 1ab inhibitor

Product Properties

• ALogP: 1.9

Names and Identifiers

• Isomeric SMILES: CCC(CC)COC(=O)[C@H](C)N[P@](=O)(OC[C@@H]1[C@H]([C@H]([C@](O1)(C#N)C2=CC=C3N2N=CN=C3N)O)O)OC4=CC=CC=C4
• PubChem CID: 121304016
• Molecular Weight: 602.58

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro DMSO: 26 mg/mL (202.88 mM); Water: Insoluble; Ethanol: Insoluble

References

1. Dong Huijun, Pan Zihang, Jiao Pengtao, Ye Fei, Peng Qi, Yu Yanying, Lai Xinyuan, Li Huan, Guan Zhao, Deng Juan, Shen Tao, Tan Wenjie, Shi Yi, Ding Qiang, Luo Jianyuan, Li Tong, Zhuang Hui, Xiang Kuanhui.  (2025)  Vesicle-associated membrane protein 5 is an intrinsic defense factor for embryonic stem cells against coronaviruses.  Nature Communications,  16  (1): (1-20).  [PMID:40624080] [10.1038/s41467-025-61655-8]

2. Yun-Lu Xu, Xue-Jian Li, Wei Cai, Wen-Ying Yu, Jing Chen, Qin Lee, Yong-Jun Choi, Fang Wu, Ying-Jun Lou, Hua-Zhong Ying, Chen-Huan Yu, Qiao-Feng Wu.  (2024)  Diosmetin-7-O-β-D-glucopyranoside from Pogostemonis Herba alleviated SARS-CoV-2-induced pneumonia by reshaping macrophage polarization and limiting viral replication.  JOURNAL OF ETHNOPHARMACOLOGY,      [PMID:39182703] [10.1016/j.jep.2024.118704]

3. Chen Zhu, Kun Fu, Hu Wen, Guangqi Chen, Henggui Zhang.  (2026)  Electrophysiological and Molecular Features of Remdesivir-Induced Cardiac Toxicity in Male and Female Guinea Pigs.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,  27  (8): (3685).  [PMID:] [10.3390/ijms27083685]