RK-33 - ≥98% , CAS No.1070773-09-9

CAS: 1070773-09-9 Cat. No.: R413953 Molecular Weight: 428.44 PubChem CID: 46184988

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RK-33 - ≥98% CAS No(1070773-09-9) by Aladdin Scientific

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AVAILABLE TO ORDER

GRADE & PURITY ≥98%

Synonyms

2H-Diimidazo[4,5-d:4',5'-f][1,3]diazepin-2-one,3,7-dihydro-3,7-bis[(4-methoxyphenyl)methyl]- | RK33 | RK 33 | RK-33 | 3,7-bis(4-methoxybenzyl)-3,7-dihydro-2H-diimidazo[4,5-d:4',5'-f][1,3]diazepin-2-one

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Overview Specifications Product Properties Names and Identifiers Documentation Advanced Data Taxonomic Classification 3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solution Calculators Reviews

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Why this grade

≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -20°C,Argon charged Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Information

RK-33 RK-33 is a first-in-class small molecule inhibitor of DDX3 (a RNA helicase) and causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sensitization in DDX3-overexpressing cells.

Targets

DDX3

In vitro

RK-33 binds specifically to DDX3, but not to the closely related proteins DDX5 and DDX17. RK-33 inhibits cancer growth and radiosensitizes lung cancer cells in a DDX3-dependent manner. RK-33 has no effect on either mitochondrial respiration or ATP generation. RK-33 curbs proliferation and induces apoptosis in a DDX3-dependent fashion. Wnt signaling is mediated by DDX3 and inhibited by RK-33. RK-33 impairs radiation-induced DNA damage repair by inhibiting NHEJ activity.

In vivo

RK-33 in combination with radiation induces tumor regression in multiple mouse models of lung cancer. RK-33, at the dose used, is non-toxic in SCID mice. RK-33-treated mice do not exhibit any discernable morphological changes.

Cell Research(from reference)

Cell lines：MDA-MB-231 cells

Concentrations：7.5 μM

Incubation Time：12 h

Specifications

Synonyms

2H-Diimidazo[4, 5-d:4', 5'-f][1, 3]diazepin-2-one, 3, 7-dihydro-3, 7-bis[(4-methoxyphenyl)methyl]- | RK33 | RK 33 | RK-33 | 3, 7-bis(4-methoxybenzyl)-3, 7-dihydro-2H-diimidazo[4, 5-d:4', 5'-f][1, 3]diazepin-2-one

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

RK-33 is a first-in-class small molecule inhibitor of DDX3 (a RNA helicase) and causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sensitization in DDX3-overexpressing cells.

Storage

Store at -20°C, Argon charged

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%

Product Properties

ALogP	2.687
Rotatable Bond	6

Names and Identifiers

Pubchem Sid	488201261
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488201261
Canonical Smiles	COC1=CC=C(C=C1)CN2C=NC3=C2N=CN=C4C3=NC(=O)N4CC5=CC=C(C=C5)OC
IUPAC Name	5,11-bis[(4-methoxyphenyl)methyl]-3,5,7,9,11,13-hexazatricyclo[8.3.0.02,6]trideca-1(10),2,6,8,12-pentaen-4-one
InChIKey	COUMZXFUZDBRCZ-UHFFFAOYSA-N
INCHI	1S/C23H20N6O3/c1-31-17-7-3-15(4-8-17)11-28-14-26-19-20-22(25-13-24-21(19)28)29(23(30)27-20)12-16-5-9-18(32-2)10-6-16/h3-10,13-14H,11-12H2,1-2H3
Isomeric SMILES	COC1=CC=C(C=C1)CN2C=NC3=C2N=CN=C4C3=NC(=O)N4CC5=CC=C(C=C5)OC
PubChem CID	46184988
Molecular Weight	428.44

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Imidazodiazepines

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Imidazodiazepines
Subclass	Not available
Intermediate Tree Nodes	Not available
Direct Parent	Imidazodiazepines
Alternative Parents	Phenoxy compounds Methoxybenzenes Anisoles Alkyl aryl ethers 1,3-diazepines N-substituted imidazoles Heteroaromatic compounds Azacyclic compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Imidazo-meta-diazepine - Imidazodiazepine - Phenoxy compound - Anisole - Methoxybenzene - Phenol ether - Meta-diazepine - Alkyl aryl ether - Monocyclic benzene moiety - Benzenoid - N-substituted imidazole - Azole - Heteroaromatic compound - Imidazole - Azacycle - Ether - Organic oxygen compound - Organic nitrogen compound - Hydrocarbon derivative - Organic oxide - Organooxygen compound - Organonitrogen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as imidazodiazepines. These are organic compounds containing an imidazole ring fused to a diazepine ring. Imidazole is 5-membered ring consisting of three carbon atoms, and two nitrogen centers at the 1- and 3-positions. Diazepine is a 7-membered ring consisting of five carbon and two nitrogen atoms.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3D Structure

Associated Targets(Human)

Daoy (570 Activities)

Lot Number	Certificate Type	Date	Item
F23281030	Certificate of Analysis	Apr 03, 2026	R413953
F23281035	Certificate of Analysis	Apr 03, 2026	R413953
F23281036	Certificate of Analysis	Apr 03, 2026	R413953
F23281037	Certificate of Analysis	Apr 03, 2026	R413953
F23281038	Certificate of Analysis	Apr 03, 2026	R413953
F23281039	Certificate of Analysis	Apr 03, 2026	R413953
F23281040	Certificate of Analysis	Apr 03, 2026	R413953
F23281042	Certificate of Analysis	Apr 03, 2026	R413953
F23281043	Certificate of Analysis	Apr 03, 2026	R413953
F23281044	Certificate of Analysis	Apr 03, 2026	R413953

Solubility	Solubility (25°C) In vitro DMSO: 85 mg/mL (198.39 mM); Water: Insoluble; Ethanol: Insoluble;
Sensitivity	Moisture sensitive.
DMSO(mg / mL) Max Solubility	85
DMSO(mM) Max Solubility	198.3941742
Water(mg / mL) Max Solubility	＜1
Molecular Weight	428.400 g/mol
XLogP3	2.600
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	6
Exact Mass	428.16 Da
Monoisotopic Mass	428.16 Da
Topological Polar Surface Area	93.700 Å²
Heavy Atom Count	32
Formal Charge	0
Complexity	783.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1