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RTI-13951-33 hydrochloride - ≥98% , CAS No.R659056
AVAILABLE TO ORDER
GRADE & PURITY ≥98%
Storage
Store at -20°C,Desiccated
Shipped In
Ice chest + Ice pads
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Why this grade
≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at -20°C,Desiccated Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
RTI-13951-33 hydrochloride is a potent, selective, and brain-penetrant GPR88 agonist, with an EC 50 of 25 nM in GPR88 cAMP functional assay. RTI-13951-33 hydrochloride reduces alcohol reinforcement and intake behaviors in rats.
Appearance:Solid
IC50& Target:EC50: 25 nM (GPR88)
In Vitro:RTI-13951-33 is a potent, selective, and brain-penetrant GPR88 agonist, with an EC 50 of 25 nM in GPR88 cAMP functional assay. RTI-13951-33 elevates [ 35 S]-GTPγS binding (EC 50 , 535 nM) in mouse striatal membranes but not in membranes from GPR88 KO mice
In Vivo:RTI-13951-33 (10 and 20mg/kg, i.p.) dose-dependently decreases alcohol lever responses in a rat model of alcohol self-administration . ?\nRTI-13951-33 (10mg/kg, i.p.) has sufficient brain penetration, with t 1/2 of 48 min and 87 min in rat plasma an
Biological Activity:RTI-13951-33 hydrochloride is a potent, selective, and brain-penetrant GPR88 agonist, with an EC 50 of 25 nM in GPR88 cAMP functional assay. RTI-13951-33 hydrochloride reduces alcohol reinforcement and intake behaviors in rats .
Specifications
Specifications & Purity
≥98%
Storage
Store at -20°C, Desiccated
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Purity
≥98%
Names and Identifiers
| Canonical Smiles | COCC1=CC=C(C2=CC=C(N(C[C@@H](N)[C@@H](C)OC)C([C@H]3[C@H](C4=CC=CC=N4)C3)=O)C=C2)C=C1.Cl.Cl |
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| Molecular Weight | 532.5 |
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Chemical and Physical Properties
| Solubility | DMSO : 50 mg/mL (93.90 mM; Need ultrasonic) H2O : 50 mg/mL (93.90 mM; Need ultrasonic) |
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Solution Calculators
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