S-Me-DM1 , CAS No.912569-84-7

CAS: 912569-84-7 Cat. No.: S276125 Molecular Weight: 752.31 PubChem CID: 154705356

Synonyms

N2'-Deacetyl-N2'-(3-thiomethyl-1-oxopropyl)-maytansine

Storage

Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

Overview

Shipped at 4°C. Store at -20°C. Store under desiccating conditions.

Specifications

Synonyms

N2'-Deacetyl-N2'-(3-thiomethyl-1-oxopropyl)-maytansine

Biochemical and Physiological Mechanisms

Active metabolite of Maytansine that inhibits in vitro polymerization of tubulin. Accumulates in cells and induces mitotic arrest.

Storage

Store at -20°C, Desiccated

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Names and Identifiers

• Canonical Smiles: CC1C2CC(C(C=CC=C(CC3=CC(=C(C(=C3)OC)Cl)N(C(=O)CC(C4(C1O4)C)OC(=O)C(C)N(C)C(=O)CCSC)C)C)OC)(NC(=O)O2)O
• IUPAC Name: [(1S,2R,3S,5S,6S,16Z,18Z,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl] (2S)-2-[methyl(3-methylsulfanylpropanoyl)amino]propanoate
• InChIKey: PLYHSTGTQYPYMT-UDXCHANISA-N
• INCHI: 1S/C36H50ClN3O10S/c1-20-11-10-12-27(47-8)36(45)19-26(48-34(44)38-36)21(2)32-35(4,50-32)28(49-33(43)22(3)39(5)29(41)13-14-51-9)18-30(42)40(6)24-16-23(15-20)17-25(46-7)31(24)37/h10-12,16-17,21-22,26-28,32,45H,13-15,18-19H2,1-9H3,(H,38,44)/b12-10-,20-11-/t21-,22+,26+,27-,28+,32+,35+,36+/m1/s1
• PubChem CID: 154705356
• Molecular Weight: 752.31

Chemical and Physical Properties

• Solubility: Solubilizes at ~3mg/mL in DMSO, ~3mg/mL in Chloroform, and ~3mg/mL in MeOH