Salidroside - Moligand™, ≥98% , CAS No.10338-51-9

CAS: 10338-51-9 Cat. No.: S759750 Molecular Weight: 300.31 EC Number: 695-621-2 PubChem CID: 159278
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GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
Synonyms
Rhodioloside
Storage
Room temperature
Shipped In
Normal
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Size
Status
Price
Qty
1g
S759750-1g
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
$52.90
5g
S759750-5g
1
$139.90
25g
S759750-25g
1
$461.90
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Why this grade

Moligand™, ≥98% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Room temperature Ships Normal Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 23 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Natural product derived from plant source.
Reference standard in the analysis of herbal medicinal products.

Specifications

Synonyms
Rhodioloside
Specifications & Purity
Moligand™, ≥98%
Biochemical and Physiological Mechanisms
Salidroside, the 8-O-β-D-glucoside of tyrosol, is the main bioactive component of Rhodiola species and is found mainly in the plant roots. It is biosynthesised in the tyrosine metabolism, with glucosylation of tyrosol being the final step. It has been rep
Storage
Room temperature
Shipped In
Normal
Grade
Moligand™
Purity
≥98%
Names and Identifiers
Canonical SmilesC1=CC(=CC=C1CCOC2C(C(C(C(O2)CO)O)O)O)O
IUPAC Name(2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-[2-(4-hydroxyphenyl)ethoxy]oxane-3,4,5-triol
InChIKeyILRCGYURZSFMEG-RKQHYHRCSA-N
INCHI1S/C14H20O7/c15-7-10-11(17)12(18)13(19)14(21-10)20-6-5-8-1-3-9(16)4-2-8/h1-4,10-19H,5-7H2/t10-,11-,12+,13-,14-/m1/s1
Isomeric SMILES C1=CC(=CC=C1CCO[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O)O
PubChem CID 159278
Molecular Weight 300.31

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganic oxygen compounds
ClassOrganooxygen compounds
SubclassCarbohydrates and carbohydrate conjugates
Intermediate Tree Nodes Glycosyl compounds
Direct ParentO-glycosyl compounds
Alternative Parents Tyrosols and derivatives  1-hydroxy-2-unsubstituted benzenoids  Oxanes  Monosaccharides  Benzene and substituted derivatives  Secondary alcohols  Polyols  Oxacyclic compounds  Acetals  Primary alcohols  Hydrocarbon derivatives  
Molecular FrameworkAromatic heteromonocyclic compounds
Substituents O-glycosyl compound - Tyrosol derivative - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Monocyclic benzene moiety - Monosaccharide - Oxane - Benzenoid - Secondary alcohol - Polyol - Oxacycle - Organoheterocyclic compound - Acetal - Hydrocarbon derivative - Alcohol - Primary alcohol - Aromatic heteromonocyclic compound
DescriptionThis compound belongs to the class of organic compounds known as o-glycosyl compounds. These are glycoside in which a sugar group is bonded through one carbon to another group via a O-glycosidic bond.
External Descriptors glycoside
3D Structure
Interactive Chemical Structure Model





Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

10 results found

Lot NumberCertificate TypeDateItem
E2628110Certificate of AnalysisAug 04, 2025 S759750
H2501729Certificate of AnalysisAug 04, 2025 S759750
H2501730Certificate of AnalysisAug 04, 2025 S759750
H2501740Certificate of AnalysisAug 04, 2025 S759750
A2513523Certificate of AnalysisJan 17, 2025 S759750
A2513533Certificate of AnalysisJan 17, 2025 S759750
A2513534Certificate of AnalysisJan 17, 2025 S759750
A2513535Certificate of AnalysisJan 17, 2025 S759750
A2513543Certificate of AnalysisJan 17, 2025 S759750
A2513544Certificate of AnalysisJan 17, 2025 S759750
Chemical and Physical Properties
Molecular Weight300.300 g/mol
XLogP3-0.600
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Exact Mass300.121 Da
Monoisotopic Mass300.121 Da
Topological Polar Surface Area120.000 Ų
Heavy Atom Count21
Formal Charge0
Complexity306.000
Isotope Atom Count0
Defined Atom Stereocenter Count5
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Citations of This Product
References
1. Yanhong Bi, Ruiping Fu, Weiliang Hua, Xinyu Xiong, Chun Zhu, Xiaobao Nie, Zhaoyu Wang.  (2025)  An empirical exploration of the capacity of choline chloride/lactic acid eutectics to extract and stabilize natural polyhydroxy compounds.  FOOD CHEMISTRY,      [PMID:40120314] [10.1016/j.foodchem.2025.143873]
2. Zhibin Zhou, Mengzhen Zhao, Huaqiang Fang, Ziyue Lin, Xinrui Zheng, Yi Zhuo, Zimeng Li, Weiming Zhou, Xiaolei Wang.  (2024)  Conductive hydrogel with responsive release of Herbal-Derived carbon dots for neurovascular reconstruction in diabetic critical limb ischemia.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2024.157265]
3. Jishan Li, Muyang Li, Chenyu Yong, Zhemin Zhou, Laichuang Han, Zhongmei Liu.  (2025)  Reshaping UDP-binding pocket of bacterial sucrose synthase to improve efficiency of UDP-glucose production.  BIORESOURCE TECHNOLOGY,      [PMID:40090494] [10.1016/j.biortech.2025.132396]
4. Qi Ouyang, Shengye Tian, Hengyu Zhou, Ying Mao, Xiang Li, Feng Yan, Ailong Liu, Xiang Hu, Changqiao You, Jun He.  (2025)  Salidroside inhibits melanin synthesis and melanoma growth via mTOR and PI3K/Akt pathways.  Frontiers in Oncology,      [PMID:40708947] [10.3389/fonc.2025.1583580]
5. Junjie Liu, Jingjing Liu, Yuxin Qiao, Hanxin Zhong, Jiaoxia Wei, Dongyang Han, Jin Peng, Yongzhou Feng, Danni Wang, Yujie Cheng, Haitao Lu, Li Yao.  (2025)  Rhodiola crenulata extract inhibits cell pyroptosis to ameliorate pulmonary vascular remodeling in rats through the regulation of decadienylcarnitine/NLRP3/GSDMD axis.  JOURNAL OF ETHNOPHARMACOLOGY,      [PMID:40850654] [10.1016/j.jep.2025.120439]
6. Guo Yibing, Zheng Cheng, Xu Wen, Si Yongxing, Dou Sufeng, Yang Yumin.  (2012)  Free radical scavenging and hepatoprotective effects of salidroside analogs on CCl4-induced cytotoxicity in LO2 cells.  MEDICINAL CHEMISTRY RESEARCH,  22  (5): (2524-2530).  [PMID:] [10.1007/s00044-012-0247-z]
7. Fei Wang, Fan Yang, Jiawei Liu, Quan Bai.  (2023)  Studies on the retention mechanism of solutes in hydrophilic interaction chromatography using stoichiometric displacement theory II. HILIC/RPLC dual-retention mechanism of solutes in hydrophilic interaction chromatography over the entire range of water concentration in mobile phase.  TALANTA,      [PMID:37385194] [10.1016/j.talanta.2023.124858]
8. Qi Liang, Rongjie Guo, Jia-Ruei Tsao, Yun He, Chenchen Wang, Jiaxuan Jiang, Di Zhang, Taige Chen, Tingting Yue, Kai Hu.  (2023)  Salidroside alleviates oxidative stress in dry eye disease by activating autophagy through AMPK-Sirt1 pathway.  INTERNATIONAL IMMUNOPHARMACOLOGY,      [PMID:37302369] [10.1016/j.intimp.2023.110397]
9. Yang Rongling, Wang Yu, Zhao Xiangjie, Tong Zheng, Zhu Qianlin, He Xiaoxi, Wang Zhaoyu, Luo Hongzhen, Fang Fang.  (2022)  A facile and efficient synthesis approach of salidroside esters by whole-cell biocatalysts in organic solvents.  Frontiers in Bioengineering and Biotechnology,      [PMID:36507279] [10.3389/fbioe.2022.1051117]
10. Jiaqi Li, Yongguang Zhang, Zhimin Yang, Jingxian Zhang, Ren Lin, Daoshu Luo.  (2020)  Salidroside promotes sciatic nerve regeneration following combined application epimysium conduit and Schwann cells in rats.  EXPERIMENTAL BIOLOGY AND MEDICINE,      [PMID:32053008] [10.1177/1535370220906541]
11. Xiaojing SI, Chaolin WANG, Li LI, Daixin YE, Youli WEI, Yaping DING.  (2020)  Preparation of nickel-aluminum hydrotalcite nanosheet-coated carbon nanofibers and their application in the detection of salidroside.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2020.104652]
12. Shasha Chen, Feng Cai, Jirong Wang, Zhouxin Yang, Chi Gu, Guofu Wang, Genxiang Mao, Jing Yan.  (2019)  Salidroside protects SH‑SY5Y from pathogenic α‑synuclein by promoting cell autophagy via mediation of mTOR/p70S6K signaling.  Molecular Medicine Reports,  20  (1): (529-538).  [PMID:31180515] [10.3892/mmr.2019.10285]
13. Jiahong Han, Min Dai, Yan Zhao, Enbo Cai, Lianxue Zhang, Xiaohuan Jia, Nian Sun, Xuan Fei, Hui Shu.  (2019)  Compatibility effects of ginseng and Ligustrum lucidum Ait herb pair on hematopoietic recovery in mice with cyclophosphamide-induced myelosuppression and its material basis.  Journal of Ginseng Research,      [PMID:32148411] [10.1016/j.jgr.2019.01.001]
14. Zhou Fei, Zhao Yajing, Li Maiquan, Xu Tao, Zhang Liuquan, Lu Baiyi, Wu Xiaodan, Ge Zhiwei.  (2017)  Degradation of phenylethanoid glycosides in Osmanthus fragrans Lour. flowers and its effect on anti-hypoxia activity.  Scientific Reports,  (1): (1-10).  [PMID:28855701] [10.1038/s41598-017-10411-0]
15. Zhilin Qi, Shimei Qi, Liefeng Ling, Jun Lv, Zunyong Feng.  (2016)  Salidroside attenuates inflammatory response via suppressing JAK2-STAT3 pathway activation and preventing STAT3 transfer into nucleus.  INTERNATIONAL IMMUNOPHARMACOLOGY,      [PMID:27085677] [10.1016/j.intimp.2016.04.004]
16. Yanfen Bai, Hua Yin, Huiping Bi, Yibin Zhuang, Tao Liu, Yanhe Ma.  (2016)  De novo biosynthesis of Gastrodin in Escherichia coli.  METABOLIC ENGINEERING,      [PMID:26804288] [10.1016/j.ymben.2016.01.002]
17. Yibo Feng, Xiaojuan Zhao, Fang Lv, Jinqiu Zhang, Bihua Deng, Yanhong Zhao, Yuanliang Hu, Deyun Wang, Jiaguo Liu, Yu Lu, Ruonan Bo, Zhenguang Liu.  (2015)  Optimization on Preparation Conditions of Salidroside Liposome and Its Immunological Activity on PCV-2 in Mice.  Evidence-based Complementary and Alternative Medicine,      [PMID:25878712] [10.1155/2015/178128]
18. Lingyun Xiao, Haifeng Li, Ju Zhang, Fan Yang, Aizhen Huang, Jingjing Deng, Ming Liang, Fangli Ma, Minghua Hu, Zebo Huang.  (2014)  Salidroside Protects Caenorhabditis elegans Neurons from Polyglutamine-Mediated Toxicity by Reducing Oxidative Stress.  MOLECULES,  19  (6): (7757-7769).  [PMID:24918543] [10.3390/molecules19067757]
19. Huang Manqian, Tang Meiling, Liu Lu.  (2025)  Salidroside Attenuates Epilepsy and Cognitive Dysfunction in Rats by Downregulating Complement C3-C3aR Pathway-Mediated Activation of Microglia and Astrocytes.  NEUROCHEMICAL RESEARCH,  50  (5): (1-12).  [PMID:40839226] [10.1007/s11064-025-04514-8]
20. Tongyao Zhao, Yao Chen, Haimeng Yuan, Shuqian Yang, Hongyuan Zhang, Yuequan Wang, Shenwu Zhang, Qin Chen, Jin Sun, Zhonggui He, Cong Luo.  (2025)  One-Stone-Two-Birds Carrier-Free Nano-Cocktail Enables Synergistic Eradication of Cancer Cells/Stem Cells in Breast Cancer Treatment.  Exploration,      [PMID:] [10.1002/EXP.20240259]
21. Qinle Huang, Zhangtie Wang, Binhai Shi, Guoliang Jie, Songbai Liu, Fuli Nie, Fan Wang, Zhenjiang Zhou, Siyu Chen, Jianfu Shen, Baiyi Lu.  (2025)  Improving Nutrition and Sensory Goals: Utilizing Explainable Machine Learning and Multi-Objective Optimization to Optimize Quality of Osmanthus fragrans Extract.  Food Frontiers,      [PMID:] [10.1002/fft2.70056]
22. Xiaowen Wang, Xia Jiang, Jinjing Yang, Michael Adu-Frimpong, Mingjie Gong, Qinyang Hua, Tingyuan Li, Jiaying Li, Pengfei Pan, Elmurat Toreniyazov, Xia Cao, Jiangnan Yu, Qilong Wang, Ximing Xu.  (2025)  Preparation of chitosan-modified Moringa A liposomes and its protective effect on acute alcoholic liver injury.  JOURNAL OF LIPOSOME RESEARCH,      [PMID:40538369] [10.1080/08982104.2025.2516033]
23. Yang Shu-Xian, Liu Shu-Sen, Zhi Chen-Xiao, Wei Biao, Cheng Jin-Jun, Zhao Zhi-Gang, Bai Ming-Hua, Wang Bin, Zhu Bin.  (2026)  Network Pharmacology and Experimental Validation-based Approach to Explore the Effect and Mechanism of Scutellaria baicalensis-Rhodiola rosea Herbal Pair against Ischemic Stroke.  World Journal of Traditional Chinese Medicine,      [PMID:] [10.4103/wjtcm.wjtcm_55_25]
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