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SBP-0636457 - ≥98% , CAS No.1422180-49-1
AVAILABLE TO ORDER
GRADE & PURITY ≥98%
Storage
Store at 2-8°C
Shipped In
Wet ice
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Why this grade
≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at 2-8°C Ships Wet ice Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
SBP-0636457 (SB1-0636457) is a SMAC mimetic, and as an IAP antagonist. SBP-0636457 binds to the BIR-domains of the IAP proteins , with a K i of 0.27 μM. SBP-0636457 can be used for the research of solid tumors and hematologic cancers
In Vitro
SBP-0636457 (1-20 μM) demonstrates no cytotoxicity in BT474, BT549, MCF7, and MDA-MB-231 breast cancer cell lines up to a concentration of 20μM. SBP-0636457 (10-1000 nM; 20 h) is efficacious as TRAIL-sensitizing agents in MDA-MB-231 cells, with an EC 50 of 9 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
IC50& Target:XIAP 0.27 μM (Ki)
Specifications
Specifications & Purity
≥98%
Biochemical and Physiological Mechanisms
SBP-0636457 (SB1-0636457) is a SMAC mimetic, and as an IAP antagonist. SBP-0636457 binds to the BIR-domains of the IAP proteins , with a K i of 0.27 μM. SBP-0636457 can be used for the research of solid tumors and hematologic cancers.
Storage
Store at 2-8°C
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Purity
≥98%
Names and Identifiers
| Canonical Smiles | O=C([C@@H]1C(C)(C)C[C@](N21)([H])OCC[C@H](NC([C@@H](NC)C)=O)C2=O)N[C@@H]3CCCC4=C3C=CC=C4 |
|---|---|
| Molecular Weight | 456.58 |
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Chemical and Physical Properties
| Solubility | DMSO : 45.71 mg/mL (100.11 mM; ultrasonic and warming and heat to 60°C) |
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Solution Calculators
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Customer Reviews
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