SC 144 hydrochloride - ≥98%(HPLC) , CAS No.917497-70-2

CAS: 917497-70-2 Cat. No.: S288107 Molecular Weight: 358.76 EC Number: 806-049-1 PubChem CID: 66921431

GRADE & PURITY ≥98%(HPLC)

Synonyms

SCHEMBL1147705 | 2-(7-Fluoropyrrolo[1,2-a]quinoxalin-4-yl) 2-pyrazinecarboxylic acid hydrazide hydrochloride | N'-(7-fluoropyrrolo[1,2-a]quinoxalin-4-yl)pyrazine-2-carbohydrazide hydrochloride | SC144 hydrochloride | SC-144 hydrochloride | AC9594 | AKOS02

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Application：

SC144 hydrochloride has been used:

as a glycoprotein 130 (gp130) inhibitor to evaluate the effect of bazedoxifene on interleukin (IL-6) mediated cell viability in pancreatic cancer cells

as a gp130 inhibitor to study its effects on signal transducer and activator of transcription 3 (STAT3) activation in mesenchymal precursor cells (KMM) cells

as an interleukin 6 signal transducer (IL-6ST) inhibitor in media to test its ability to block serum-induced migration/invasion

Specifications

Synonyms

SCHEMBL1147705 | 2-(7-Fluoropyrrolo[1, 2-a]quinoxalin-4-yl) 2-pyrazinecarboxylic acid hydrazide hydrochloride | N'-(7-fluoropyrrolo[1, 2-a]quinoxalin-4-yl)pyrazine-2-carbohydrazide hydrochloride | SC144 hydrochloride | SC-144 hydrochloride | AC9594 | AKOS02

Specifications & Purity

≥98%(HPLC)

Biochemical and Physiological Mechanisms

Inhibitor of gp130 (IC50= 0.72μM); blocks cytokine-triggered gp130 signaling. Induces gp130 phosphorylation and down regulates gp130 glycosylation; also abrogates STAT3 phosphorylation, nuclear translocation and inhibits the expression of downstream targe

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%(HPLC)

Names and Identifiers

• Pubchem Sid: 504771866
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504771866
• Canonical Smiles: C1=CN2C3=C(C=C(C=C3)F)N=C(C2=C1)NNC(=O)C4=NC=CN=C4.Cl
• IUPAC Name: N'-(7-fluoropyrrolo[1,2-a]quinoxalin-4-yl)pyrazine-2-carbohydrazide;hydrochloride
• InChIKey: LKFGGXYXFIICED-UHFFFAOYSA-N
• INCHI: 1S/C16H11FN6O.ClH/c17-10-3-4-13-11(8-10)20-15(14-2-1-7-23(13)14)21-22-16(24)12-9-18-5-6-19-12;/h1-9H,(H,20,21)(H,22,24);1H
• Isomeric SMILES: C1=CN2C3=C(C=C(C=C3)F)N=C(C2=C1)NNC(=O)C4=NC=CN=C4.Cl
• WGK Germany: 3
• PubChem CID: 66921431
• Molecular Weight: 358.76

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Class Diazanaphthalenes
      • Subclass Benzodiazines
        • Level5 Quinoxalines
          • Level6 Pyrroloquinoxalines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Class: Diazanaphthalenes
• Subclass: Benzodiazines
• Intermediate Tree Nodes: Quinoxalines
• Direct Parent: Pyrroloquinoxalines
• Alternative Parents: Pyrrolopyrazines Pyrazinecarboxamides Imidolactams Benzenoids Aryl fluorides Pyrroles Heteroaromatic compounds Carboxylic acid hydrazides Azacyclic compounds Organooxygen compounds Organonitrogen compounds Organofluorides Organic oxides Hydrochlorides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Pyrroloquinoxaline - Pyrazine carboxylic acid or derivatives - Pyrazinecarboxamide - Pyrrolopyrazine - Aryl fluoride - Aryl halide - Pyrazine - Imidolactam - Benzenoid - Heteroaromatic compound - Pyrrole - Carboxylic acid hydrazide - Carboxylic acid derivative - Azacycle - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Organofluoride - Organohalogen compound - Organic oxide - Organic oxygen compound - Organic nitrogen compound - Hydrochloride - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as pyrroloquinoxalines. These are organic heterocyclic compounds containing a pyrrole ring fused to a quinoxaline ring system.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Solubility: Solvent:DMSO, Max Conc. mg/mL: 32.23, Max Conc. mM: 100
• Sensitivity: Moisture sensitive
• Molecular Weight: 358.760 g/mol
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 3
• Exact Mass: 358.075 Da
• Monoisotopic Mass: 358.075 Da
• Topological Polar Surface Area: 84.200 Ų
• Heavy Atom Count: 25
• Formal Charge: 0
• Complexity: 466.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3